Anders Norman

The power of resistance: mechanisms of antimicrobial resistance in Mycobacterium tuberculosis and its impact on tuberculosis management | Clinical Microbiology Reviews SUMMARYThe global resurgence of drug-resistant tuberculosis (DR-TB) presents a formidable challenge to public health, driven by a complex interplay of mycobacterial evolution, dynamics and outcomes of...

The power of resistance: mechanisms of antimicrobial resistance in Mycobacterium tuberculosis and its impact on tuberculosis management | Clinical Microbiology Reviews journals.asm.org/doi/10.1128/...

Population structure of Mycobacterium avium subsp. hominissuis provides new insights into genomic evolution Mycobacterium avium subsp. hominissuis (MAH) is a clinically important species of non-tuberculous mycobacteria that causes infections in a variety of hosts. This opportunistic pathogen is widespread i...

Just saw this. Amazing work
www.microbiologyresearch.org/content/jour...
#idsky #ntmsky #ntm

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

Biofilm formation by the global outbreak strain of Mycobacterium chimaera results in significantly reduced efficacy of standard disinfectants - BMC Microbiology Background In 2013, a global outbreak of Mycobacterium chimaera infections due to contaminated heater-cooler units emerged. This ongoing problem has highlighted the question of whether disinfection re...

link.springer.com/article/10.1...

Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.

Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky

Non-conjugative plasmids limit their mobility to persist in nature Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...

New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...

Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025–34: a mathematical modelling study Without actions to restore discontinued services, cuts to health aid for tuberculosis and HIV programmes could result in millions of additional childhood tuberculosis cases and deaths in low-income an...

New research from Nicolas Menzies & colleagues: Potential #paediatric #tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025–34: a mathematical modelling study

www.thelancet.com/journals/lan...

#PedSky #InternationalAid

Call for Papers: Nontuberculous Mycobacterial (NTM) Pathogens─Biology, Infection, and Drug Discovery

Announcing a call for a special issue on Nontuberculous Mycobacterial (NTM) Pathogens, led by our guest editors Sidharth Chopra, Arunava Dasgupta and @lkremer1.bsky.social! Accepting manuscripts on various themes.
Deadline - March 30, 2026.
@pubs.acs.org
Link - pubs.acs.org/doi/10.1021/...

Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...

What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?

Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...

Fun fact: diluted tattoo inks and washes make pretty decent carbon sources for NTMs.

The social determinants of tuberculosis: a case-control study characterising pathways to equitable intervention in Peru - Infectious Diseases of Poverty Background Despite being key components of global tuberculosis policy, poverty reduction and social protection interventions have been inconsistently implemented. We aimed to characterise how poverty ...

The global TB epidemic is driven by social determinants. In this case-control study in Peru, we characterised the associations between multidimensional household poverty, personal risk factors, and TB. @tb-lshtm.bsky.social idpjournal.biomedcentral.com/articles/10....

Really pleased to see this study led by @raymondkiu.bsky.social now published in @natcomms.nature.com!

We show that probiotics help modulate the preterm infant 👶#microbiome - to reduce ARGs, lower MDR bacteria 🦠 & increase beneficial Bifido ✨

Huge team effort!

www.nature.com/articles/s41...

Convolutional neural networks quantify antibiotic resistance in Mycobacterium tuberculosis with diagnostic grade accuracy and predict treatment response There is considerable interest in training machine learning (ML) models on genomic data that achieve clinical grade diagnostic accuracy. Many successful ML models have been trained and validated on bi...

www.medrxiv.org/content/10.1...

#TBSky #IDSky #Tuberculosis

Extraordinarily high incidence rates of tuberculosis among Greenlanders living in Denmark, 2006–2022 Many Greenlanders move from Greenland, a tuberculosis (TB) high-incidence country, to Denmark, a TB low-incidence country. Surprisingly, according to official statistics, the TB incidence among Gre...

Our study on TB rates among Greenlanders in Denmark is out: doi.org/10.1080/2374...

The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness - Nature Communications Effe et al. evaluate how specific plasmid traits influence plasmid fitness; they provide mechanistic insight into the persistence of large conjugative plasmids, including those that disseminate antibi...

Happy to finally share this! Read here about the best strategy the the persistence of low-copy plasmids. @mariosanter.bsky.social @iwangtoknow.bsky.social doi.org/10.1038/s414...

UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis of Mycobacterium tuberculosis Mycobacterium tuberculosis, the bacterium responsible for the Tuberculosis (TB) disease, remains a leading global infectious disease killer, and genomic epidemiology is essential for understanding its...

www.medrxiv.org/content/10.1...

graphical abstract of the article the extended mobility of plasmids

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

The spatiotemporal distribution of human pathogens in ancient Eurasia Nature - Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and...

rdcu.be/evzMK

BEAST X for Bayesian phylogenetic, phylogeographic and phylodynamic inference - Nature Methods BEAST X advances Bayesian phylogenetic, phylogeographic and phylodynamic analysis by incorporating a broad range of complex models and leveraging advanced algorithms and techniques to boost statistica...

www.nature.com/articles/s41...

Genotyping and transmission analysis of Mycobacterium tuberculosis in a pediatric population in Czech Republic and Slovakia - BMC Infectious Diseases Background Tuberculosis remains a global health concern, with rising pediatric and adolescent cases. The advancement of diagnostic strategies is crucial for effective control, with whole-genome sequen...

link.springer.com/article/10.1...

Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases Background Pathogenic mycobacteria, such as Mycobacterium tuberculosis complex (Mtbc), and non-tuberculous mycobacteria (NTMs) can cause severe chronic pulmonary infections. However, not all infected ...

dx.plos.org/10.1371/jour...

They have tours you can go on nbarchive.ku.dk/visit-us/tou...

And that's a wrap on #ESM2025! A huge thank you to our incredible community of scientists, speakers, and organizers who made this week unforgettable. The future of mycobacteriology is bright! See you all in 2026! 👋 #Tuberculosis #Science

Great presentation from Xenia at #esm2025 supported by @micronorman.bsky.social and @tlillebaek.bsky.social and others on decades of NTM isolates from patients and how it changes over those years.

😱

YouTube video by Protagonist Science Chasing the bat origins of SARS-CoV-2

One of my favorite papers; congratulations @spyroslytras.bsky.social and Jonathan Pekar!

Here is our chat about this remarkabe work and what it means for the zoonotic origins of COVID-19

www.youtube.com/watch?v=ROUd...

Mycobacteria beyond disease Mycobacteria have coevolved with humans over millennia, leaving profound imprints on our immune systems. Beyond active disease, their exposure may exert immunomodulatory effects, including allergy mod...

www.cell.com/trends/micro...

Assemblies of long-read metagenomes suffer from diverse errors Genomes from metagenomes have revolutionised our understanding of microbial diversity, ecology, and evolution, propelling advances in basic science, biomedicine, and biotechnology. Assembly algorithms...

www.biorxiv.org/content/10.1...

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!