Vivek Mutalik

40 days for nothing 🤦🏽‍♂️

#microsky

#microsky

Strain displacement in microbiomes via ecological competition - Nature Microbiology Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.

Strain displacement in microbiomes via ecological competition

Cool @natmicrobiol.nature.com publication by @erikbakkeren.bsky.social
@vit-pi.bsky.social @meganleeny.bsky.social @microscape.bsky.social & Kevin Foster

www.nature.com/articles/s41...

Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli We developed an integrated platform that combines in situ transposon mutagenesis, biosensor-guided selection, and multiplex automated genome engineering. This approach significantly accelerates the id...

#microsky

Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology www.cell.com/trends/biote...

High-throughput conjugation reveals strain specific recombination patterns enabling precise trait mapping in Escherichia coli Author summary Escherichia coli demonstrates a remarkable ability to adapt to diverse environments. This adaptability is in part connected to its ability to recombine incoming DNA in its chromosome, a...

#microsky 😮

journals.plos.org/plosgenetics...

😳😬

#microsky 😳

#phage #phagesky #microsky

😮

😳😮

OpenAI bubble coming at you faster than you realize

Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky

#microsky

Happy to see this day

😊

A membrane-bound nuclease directly cleaves phage DNA during genome injection From mammals to bacteria, the direct recognition and cleavage of viral nucleic acids is a potent defense strategy against viral infection, but it requires mechanisms for distinguishing self from non-s...

#phahe #phagesky

www.biorxiv.org/content/10.1...

We are all waiting for some miracle to save us from insanity in every aspect of life here

Halloween costume

Halloween costume

Halloween costume

Halloween 🎃 🎉

& state of US science

Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...

#microsky

Another 💎 from Byoung-Mo and Horia and-Gross lab at UCSF

Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi: Cell Systems www.cell.com/cell-systems...

#microsky

😬

Advances in biosensors for microbial biosynthesis of amino acids and their derivatives Amino acids and their derivatives play pivotal roles across diverse fields including biotechnology, pharmaceuticals, agriculture, and industrial manuf…

#synbiosky #microsky

www.sciencedirect.com/science/arti...

I love kids. I have two of them. They’re amazing. However, kids are the absolute least self aware, clumsiest little puffins on the planet.

Please don’t drive tonight unless you have to, and if you do drive, drive super slow and pay 100% attention at all times.

Happy Halloween! 🎃 👻 💀

#PublicHealth

#phage #phagesky

All the world’s a phage | PNAS A renewed interest in bacteriophages has emerged from the explosive discovery of the complex pan-immune bacterial defense system and a revival of t...

😍
#phage #phagesky

www.pnas.org/doi/full/10....

Temperature as a Driver of Phage Ecology and Evolution Bacteriophages (phages) are virtually ubiquitous and play a fundamental role in the ecological and evolutionary dynamics of their bacterial hosts. While phages are found across many thermal environmen...

Temperature as a Driver of Phage Ecology and Evolution

#phage
#phagesky

- www.annualreviews.org/content/jour...

#phage #phagesky

🥲🙁

Global antibiotic resistance surveillance report 2025 This new WHO report presents a global analysis of antibiotic resistance prevalence and trends, drawing on more than 23 million bacteriologically confirmed cases of bloodstream infections, urinary trac...

Some alarming alarming #AMR numbers from WHO

www.who.int/publications...

#phage #phagesky

Agree, at the same time, I still feel I would like to see this to be proven by isolations at large scale & test the broad host range to support a new tech