Roger Baudouin Dillmann

Read more about the reflections on 2024 in the Annual Report ➡️ www.bothends.org/en/Whats-new...

Solution Conformation of the Synthetic Bovine Proenkephalin-A209–237 by 1H NMR Spectroscopy* Proenkephalin-A has been described to generate enkephalins, opoid peptides, and several derived peptides, which display various biological effects, including antinociception and immunological enhancem...

Solution Conformation of the Synthetic Bovine Proenkephalin-A209–237 by 1H NMR Spectroscopy* - Journal of Biological Chemistry www.jbc.org/article/S002...

La VP des Relations Internationales d’UPSaclay Delphine Placidi-Frot a accueilli une délégation de la Nanyang Technological University de Singapour afin de discuter des perspectives de collaboration en #Formation #Recherche dans les domaines de la #santé #biologie #chimie #physique #mathématiques.

Congratulations Prof. Dame Clare Grey, hope to see you in Kenya soon.

Prof. Dame Clare Grey, The 2025 recipient of the Richard R. Ernst Gold Medal

Prof. Dame Clare Grey @greygroupcam.bsky.social is the 2025 recipient of the Richard R. Ernst Gold Medal @ethzurich.bsky.social chab.ethz.ch/en/research/... #NMRchat #NMR #BattChat 🧲🔋

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#NMRchat Predicting and interpreting EPR spectra of POPC lipid bilayers with transmembrane α-helical peptides from all-atom molecular dynamics simulations http://pubs.rsc.org/en/Content/ArticleLanding/2025/CP/D4CP04802D

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#NMRchat Quantitative NMR for detection of spinosad residues in agricultural soils http://pubs.rsc.org/en/Content/ArticleLanding/2025/RA/D5RA00356C

Filters for letting the RF from or mixers do not have to be nice, just efficient enough #FrugalLiving in #NMR with less than 30€, Thanks to AKachilia and Stanley for his first attempt to build an RF filter !

Very inspiring person for all those who worked on molecular structure and dynamics...

Announcement by the Dean of Faculty of Arts and Sciences of the death of Martin Karplus.

The Nobel Prize-winning chemist, Martin Karplus, has passed away. A pioneer in the theory and computation of the dynamics of macromolecules. 🧪 #ChemSky

A great thanks for your work !

Hyperpolarized 13C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease NMR is a central tool in the field of metabolomics, thanks to its ability to provide valuable structural and quantitative information with high precision. Most NMR-based metabolomics studies rely on 1D 1H detection, which is heavily limited by strong peak overlap. 13C NMR benefits from a wider spectral dispersion and narrower signal line width but is barely used in metabolomics due to its low sensitivity. Dissolution dynamic nuclear polarization (d-DNP) offers an opportunity to improve 13C NMR sensitivity by several orders of magnitude. Here, we show that this emerging hyperpolarized metabolomics approach can provide meaningful information about clinical samples. Achieving sub-mM limits of detection with 13C at natural abundance in urine samples was made possible by a meticulous design of the experimental workflow. The analysis of human urine samples from patients with different stages of chronic kidney disease (CKD) was performed using 13C d-DNP NMR and benchmarked to conventional 1H NMR metabolomics at a high magnetic field to explore the complementarity between the two methods. Multivariate analysis of the d-DNP 13C NMR dataset provided a statistical model able to distinguish patients with CKD from control patients. Moreover, 13C d-DNP NMR spectra highlighted several biomarkers known to be biologically relevant. Some of them were in agreement with those obtained with conventional 1H NMR, and the results also highlighted the complementarity of biomarker coverage between hyperpolarized and conventional NMR metabolomics. In particular, 13C hyperpolarized NMR allowed the annotation of two biomarkers that could not be detected by 1H NMR because of peak overlap (i.e., guanine and guanidoacetate).

Why compromising between resolution and sensitivity in #NMR #metabolomics when you can have both? Learn more in our just published @acsjacs.bsky.social paper!

doi.org/10.1021/jacs...

Nice reference, any think up there in #NMR operando ? link.springer.com/article/10.1...

Congratulations!

No longer advertising... sorry

In other news: today I was granted indefinite leave to remain in the UK aka job freedom. I am looking for a UK-based (or remote) job after a looong stint in the Levitt group. You might find me useful if you want a pulse sequence guru. #nmrchat

My CV: sabba.me/nmr/cv/

Excursion on Kijabe, in the rift valley, #kenya, #Holidays

Delivered to Nairobi, 5m cable RG316 2.5mm, for less than 10€ in less than two weeks...