Shayan Mohammadmoradi, M.S. Ph.D

Grateful for good science, good food, and the lab mates who make both better!

Happy Thanksgiving from our lab!

‘Mind the (Gender) Gap’: Aspirin's paradoxical acceleration of aneurysm growth in women Aortic aneurysms remain a significant health concern with complex pathophysiology and limited pharmacological management options. Despite advancements in surgical techniques, the search for effective ...

New editorial in Atherosclerosis highlights our latest work!

Using an AI-driven method to extract aortic diameters from EHRs, we uncover sex-specific responses to antiplatelet therapy in aneurysmal patients.

@eassociety.bsky.social

Read more:
www.atherosclerosis-journal.com/article/S002...

GLP-1 meds (like Ozempic & Mounjaro) help with weight loss—but they’re not magic.
💪 Eat protein to protect muscle
🥦 Choose whole foods
🚫 Avoid extreme diets
🏋️‍♂️ Add resistance training
🧠 Manage stress & sleep

Meds stop working without lifestyle change.

ajcn.nutrition.org/article/S000...

These data raise important questions about sex-specific antiplatelet strategies in aneurysm management—especially given women’s higher rupture risk at smaller diameters.

This study shows how AI tools like GPT-4 can transform EHR analysis and precision medicine.

Main findings:

✅ Platelet counts were significantly lower in AAA and TAA patients.

✅ Aspirin had no effect on TAA or male AAA progression.

‼️BUT: In women with small AAAs (<50mm), aspirin accelerated aneurysm growth.

We developed a GPT-4 powered NLP tool to extract aortic diameter measurements from 13 years of radiology reports—an AI-first in aneurysm research.

Using this dataset, we examined how aspirin affects AAA and TAA growth across 443 patients with serial imaging.

Impact of Aspirin Therapy on Progression of Thoracic and Abdominal Aortic Aneurysms Aortic aneurysms, including abdominal (AAA) and thoracic (TAA), pose significant challenges due to their rupture risk and complex pathophysiology. While aspirin has been proposed to manage aneurysm pr...

Excited to share that our new study is in press! We investigated how aspirin therapy impacts aortic aneurysm progression with a little help from Open AI's ChatGPT.

A thread:

#cardiosky #medsky @ukresearch.bsky.social

www.atherosclerosis-journal.com/article/S002...

Honored to be named the winner of University of Kentucky College of Medicine 16th Annual Trainee Research Day. Grateful for the recognition & excited to discuss the role of platelets in vascular disease in the Dean’s Distinguished Lecture Series. Join us today from 2–3 PM.

@ukresearch.bsky.social

Thank you!

YouTube video by AHAScience Brinkhous Award Winner Shayan Mohammadmoradi, MD

Learn more about my project as I discuss our work showing that VAMP8 deficiency mitigates AngII-induced abdominal aortic aneurysms by reprogramming platelets. Watch here:

@ahascience.bsky.social @ukresearch.bsky.social

www.youtube.com/watch?v=j2Sv...

Thank you Ryan!

🙏🙏🙏

Thank you Parham!

Honored to receive the Brinkhous Early Career Investigator Prize in Thrombosis at Vascular Discovery . I’m deeply grateful to @americanheart.bsky.social, my mentors, collaborators, & all who’ve supported & sponsored me.

#medsky #cardiosky

New acknowledgment slide picture unlocked. I am having too much fun with this.

#NIHfunding cuts have resulted in stalled research. In response, ASH is expanding its Bridge Grant Program with $150K in awards to support critical research by members. Donate to support #hematology researchers and help ensure innovative research continues: https://bit.ly/41LFwjD

#HemeSky #MedSky

Happy Persian New Year - ⁦‪#Nowruz‬⁩. May it bring prosperity, happiness, freedom, & new opportunities.

‎While we cherish the memories of those who are no longer with us, we step forward with optimism, embracing what the future holds.

Saw many friends and colleagues receive wonderful news on their Match Day. Congrats to all of you—wishing you the best of luck!

(ChatGPT got too excited!)

#CardioSky #MedSky

Obituary: Janet Powell - Vascular News Janet Powell, the clinical trial investigator who played a pivotal role in several landmark abdominal aortic aneurysm (AAA) studies, has died at the age of 79. At the time of her death, Powell was pro...

A sad day for Vascular Biology. As a student working on AAA, I learned a lot from the seminal works of Dr. Powell. Her controbutiom to IMPROVE randomised controlled trial was in particular interest for me.

May she rest in peace.

vascularnews.com/obituary-jan...

Follow #CardioSky community by using starter packs

🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG

Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models | Arteriosclerosis, Thrombosis, and Vascular Biology There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induce...

A must-read for anyone working on aortic disease models. - Standardizing Experimental Thoracic Aortopathy Research.

www.ahajournals.org/doi/10.1161/...

Amazing times — Exciting science, great discussions, & even better company. It wasn’t just about cutting-edge research; it was about forming lasting friendships w/ people who share the same passion. Grateful to be part of such an inspiring community. Looking forward to the next one in Italy!

Trump administration cancels $400 million in funding to Columbia University — and says more cuts are coming The administration has alleged the school failed to combat campus anti-Semitism amid Israel-Gaza protests.

This cut affects a broad spectrum of the operations, including research, education, and patient care. This reduction is expected to significantly impact research initiatives, educational programs, and healthcare services.

Does that fight antisemitism?!

www.businessinsider.com/trump-columb...

Throughout the years, I have been inspired by the incredible women around me and their invaluable contributions. Today, we celebrate their strength, resilience, and achievements. Happy International Women’s Day!

Good work Lisa!

Thank you Parham!

Honored to be selected as a finalist for the Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis by the @ahascience.bsky.social ATVB Council. Grateful to @americanheart.bsky.social for this recognition and excited to share my work!

#Medsky #CardioSky

Thank you Lisa! Same to you!

Gave a talk after 21 hours awake, 3 cities, 2 planes, and a long drive. Pretty sure I explained platelets as a jazz band improvising clot formation.
Honestly, might be onto something. True Gordon Conference vibes.

Extremely disappointing 🤦🏻