Molecular and Cellular Function, University of Manchester

The University of Manchester, Division of Molecular and Cellular Function PhD Projects, Programmes & Scholarships - 21 PhDs Listed FindAPhD. Search Funded PhD Projects, Programmes & Scholarships at The University of Manchester, Division of Molecular and Cellular Function.

21 fully funded PhD projects are available in our division!

www.findaphd.com/phds/divisio...

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ...

New preprint from MCF:
Kerrie Marie and collaborators reveal dynamic patterns of lineage state switching correlated with melanoma tumor evolution, offering insights into potential new therapeutic targets.
www.biorxiv.org/content/10.1...

Graham Pavitt

We are excited to announce that Professor Graham Pavitt, Chair in Molecular Biology, has been appointed as our new Head of Division!
Join us in welcoming Graham to his new role—we look forward to the exciting times ahead!

research.manchester.ac.uk/en/persons/g...

In our study @elife.bsky.social we uncover the mechanism of mPPase inhibition. Over 20x structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining symmetric conformation at periplasmic site

elifesciences.org/reviewed-pre...

Very special graduation...

Congratulations Katie and @tranejoan.bsky.social !

Super excited to host Dr Kerrie L Marie @mcf-uom.bsky.social today @liigh-unam.bsky.social! She talked to us about the embryonic pathways that are co-opted by #melanoma cells, a great talk with lots of questions 🤓

We're ready for #BritishScienceWeek @ManchesterMuseum! All about #secretion, #ECMatrix assembly, from cells to #zebrafish! @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

Fantastic postdoc opportunities available @fbmh-uom.bsky.social!

💡 Please get in touch if you're interested in using biomaterials, cell biology, 'omics technologies and data science to investigate cell adhesion networks and gene expression in cancer

#science #research #jobs #careers

Exploiting the SunTag system to study the developmental regulation of mRNA translation The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...

Our researchers leb by @hilaryashe.bsky.social show the versatility of the SunTag system by providing proof-of-principle data for new avenues of exploration, quantitation and visualisation of protein synthesis.
@biologists.bsky.social

journals.biologists.com/jcs/article/...

Exploiting the SunTag system to study the developmental regulation of mRNA translation The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to study new aspects of transl...

Our new paper describes how SunTag imaging of mRNA translation can be used to study ribosome pausing in development. We also adapt the system to study translation of a secreted protein. Work done in collaboration with @mrattray.bsky.social and @markashe.bsky.social
doi.org/10.1242/jcs....

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

A new day, a new preprint!

@tranejoan.bsky.social lab demonstrated that macrophages promote collagen deposition in fibroblasts by inducing circadian rhythms, with M2-derived PDGFA playing a key role in this process.

Read here:
www.biorxiv.org/content/10.1...

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

Research Opportunities - Cancer Research UK Manchester Centre Explore the range of postgraduate cancer research opportunities available in Manchester.

Exciting PhD opportunity available in my lab for the students from Black heritage background. Apply soon. 🤞🤞🤞
@mcr-breastcentre.bsky.social @mcf-uom.bsky.social

CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity

📅 Deadline: 4 April

🔗 crukcentre.manchester.ac.uk/study/resear...

Early-career fellowships at the University of Manchester!

To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers:

www.bmh.manchester.ac.uk/research/sup...

A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project.
jobs.manchester.ac.uk/internal/Job...
@mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

New preprint!
@sankarinagarajan.bsky.social and colleagues employed machine learning approaches to identify critical gene pathways and transcription factor networks in breast cancer

Is there more to defining the eve stripes in the Drosophila embryo than just transcriptional regulation? We provide evidence that spatially regulated mRNA decay is also important.

New paper by @pliotasgroup.bsky.social !

Welcome to Bluesky @pliotasgroup.bsky.social !

Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the inve…

Paper alert!
Pliotas Group reviewed pulsed dipolar electron paramagnetic resonance spectroscopy applications and highlighted emerging strategies for future studies

www.sciencedirect.com/science/arti...

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻

Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.

doi.org/10.7554/eLif...
@elife.bsky.social

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

Paper alert!
A collaborative study led by @tranejoan.bsky.social shows that circadian-regulated endocytic recycling is central to homeostatic assembly of collagen fibrils and is disrupted in diseases.
Published in @elife.bsky.social
doi.org/10.7554/eLif...

(Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester on FindAPhD.com PhD Project - (Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression at The University of Manchester, listed on FindAPhD.com

Bicentenary PhD scholarship is available in @ximenasotouom.bsky.social group.
If you are enthusiastic and keen on using Zebrafish to elucidate signals and mechanisms involved in spinal cord regeneration apply!
Deadline is the 10th of January, 2025.
www.findaphd.com/phds/project...

Hello, Bluesky community!
We are the Division of Molecular and Cellular Function (MCF) in the Faculty of Biology, Medicine and Health at the University of Manchester.
Follow us for research updates and job opportunities!