Nael Nadif Kasri

Third time in a row authors “forget” to cite a very relevant paper with almost identical conclusions. With rushed reviews, it feels like they’re banking on reviewers missing it. Please cite the work you build on. This pattern is exhausting.

Happy to see our new study online

Thank you, It was a nice surprise and pleasure to have you visiting Nijmegen during Elly's defense.

No, Tylenol does not cause autism. And there is no compelling evidence that leucovorin reduces symptoms. A consensus summary is found here - www.coalitionofautismscientists.org

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra Syndrome GABAergic inhibition is essential for balanced brain function and is frequently disrupted in neurodevelopmental disorders such as autism spectrum disorder (ASD). The inhibition is generated by a diver...

Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra
www.biorxiv.org/content/10.1...

The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...

New #cilia preprint alert

Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"

We hope you enjoy reading it!

www.biorxiv.org/content/10.1...

-Patient-derived organoids from individuals with Koolen-de Vries syndrome reveal impaired DNA replication and reduced synapse formation, driven by excess R-loops.

Key insights:
-The NSL complex prevents R-loop accumulation at weakly transcribed promoters, safeguarding DNA replication.

-Loss of NSL disrupts S-phase progression and causes replication stress.

Led together by Brooke Latour, Jolanthe Lingeman, Haico van Attikum, and many others, we reveal a novel role of the NSL complex in safeguarding genome stability during early neural development.

THE NSL COMPLEX PROMOTES NEURAL DEVELOPMENT BY PREVENTING R-LOOP INDUCED REPLICATION STRESS Early neuronal development relies on the proliferation of neural progenitor cells, making this developmental stage particularly vulnerable to DNA replication impediments. Here, we identify a non-canon...

New preprint alert!

Excited to share our latest study, now live on bioRxiv:
"The NSL Complex Promotes Neural Development by Preventing R-Loop Induced Replication Stress"
www.biorxiv.org/content/10.1...

Rapid turnover and recurrent structural variation at the 17q21.31 locus in modern and ancient human genomes, and primates The 17q21.31 locus in humans harbors several complex structural haplotypes including a ~970kb inversion. Different inversion haplotypes have been associated with susceptibility to microdeletions causi...

Detailed characterization of the recurrent, independent evolution of a medically relevant locus across humans and great apes — the 17q21.31 locus
By @psudmant.bsky.social and colleagues
🧪🧬

www.biorxiv.org/content/10.1...

PSIDER NETWORKING MEETING: IPSC-DRIVEN THERAPEUTIC INNOVATION FOR BRAIN DISORDERS Joint meeting of the ZonMW PSIDER consortia ​ This year we organize a joint meeting of the ZonMW PSIDER consortia TAILORED and BRAINmodel, two large scientific consortia supported by ZonMW.  We...

🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders!

We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social

📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org

It was a pleasure of having @cedricboeckx.bsky.social visiting us on his way to the Max Planck in Nijmegen. He even wanted to help @ellylewerissa.bsky.social in the lab. Look at her reaction.

Deeply honoured to receive this grant from the Coalition to Cure CHD2 to advance our work on CHD2-related disorders.
Together with my outstanding PhD student, @ellylewerissa.bsky.social , we’re excited to embark on this project

What an incredible week at the GRC on Excitatory Synapses! Thrilled for the chance to share our work on building an all-human co-culture of excitatory and inhibitory neurons, astrocytes and microglia to better capture synapse biology in health and disease. A huge team effort driving this forward!

If you are at the GRC on excitatory synapses @nickyscheefhals.bsky.social will be presenting on Wednesday.

🎥 MAP2 (green), PSD95 (magenta), inhibitory neuron (blue) @naelnadifkasri-lab.bsky.social lab

Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders - Genome Medicine Background Neurodevelopmental disorders (NDDs) are a challenging group of disorders to treat, but promising therapeutic interventions in the form of antisense oligonucleotides (AONs) have emerged in r...

New paper alert! How many neurodevelopment disorders would be amenable for ASO treatment? Fabulous PhD student @Kim Wijnant, did the analysis.
genomemedicine.biomedcentral.com/articles/10....

Slow slow slow….. how human brain develops. Inspiring talk by Cedric.

Bart De Strooper giving The EMBO Keynote Lecture - From correlation to mechanisms: how genetics determine your risk of Alzheimer’s disease
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social @humantechnopole.bsky.social
@r3rt0.bsky.social

Nael Nadif Kasri @naelnadifkasri-lab.bsky.social exploring the role of the primary cilium in neuronal plasticity and development: How the quiet organelle claims center stage!
at #neurogen25
@nereokalebic.bsky.social @harschnitz.bsky.social
@humantechnopole.bsky.social
@r3rt0.bsky.social

Great work, Silvia!

RIP #JanTerlouw. Zijn boeken leerden me lezen, dromen en denken. Dank je wel, Jan.

Congrats to see this work finally out!

CHD2 Dosage Ties Autolysosomal Pathway to Cortical Maturation in Disease and Evolution The relatively slow pace of cortical development in humans has long been a topic of investigation. Studies seeking to understand the underlying mechanisms have mostly focused on neurogenetic compariso...

Bonus result: the lysosome/autophagy pathway surfaced as an important dimension of maturational tempo, in line with our recent work with @naelnadifkasri-lab.bsky.social (study led by @olivieroleonardi.bsky.social & @ellylewerissa.bsky.social)
www.biorxiv.org/content/10.1...

New paper alert!
We performed a systematic analysis of genetic and phenotypic characteristics to identify potential candidate neurodevelopmental disorders amenable for antisense
oligonucleotide therapy.
Kudos to PhD student Kim Wijnant
www.biorxiv.org/content/10.1...

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...

New paper alert on Inter-individual variation in fusion transcript expression representing an overlooked source of
genetic diversity #evolution #disease

www.biorxiv.org/content/10.1...

Vacancy - PhD candidate | Junior researcher 'Spatiotemporal properties of neuronal metabolofunction using novel on-chip technology' We are seeking a PhD candidate / junior researcher to develop and apply an innovative on-chip technology platform for integrated neuronal ...

Interested in disease modelling, stem cell models metabolism and novel on-chip technology? Then this might be an exciting project for you.

PhD position in now open
www.radboudumc.nl/en/vacancies...

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!

www.biorxiv.org/content/10.1...