Nico Barros

A must read. www.idsociety.org/globalassets...

@germhuntermd.bsky.social @natebahrid.bsky.social @fungaldoc.bsky.social

Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstitution Inflammatory Syndrome Hyunah Yoon, MD MS, Liise-anne Pirofski, MD, David R Boulware, MD MPH; Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstituti

Cool article! @drboulware.bsky.social
academic.oup.com/cid/advance-...

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge | NEJM Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.

Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge

@grthompsonmd.bsky.social and Angel Desai

www.nejm.org/doi/full/10....

Estimated Burden of Coccidioidomycosis This cross-sectional study generates a systematic and rigorous estimate of national incident symptomatic coccidioidomycosis cases by developing a model to account for cases missed through national sur...

Cannot agree more with @germhuntermd.bsky.social @fungaldoc.bsky.social @natebahrid.bsky.social
"Better awareness, diagnostic testing practices, and reporting are needed to improve patient outcomes and enhance our understanding of coccidioidomycosis epidemiology"

jamanetwork.com/journals/jam...

ISHAM targets 90-90-90

Histoplasma working group ISHAM. Let's do it! 90-90-90 for 2030!

Interferon-γ therapy in patients with refractory disseminated coccidioidomycosis Abstract. Refractory disseminated coccidioidomycosis (DCM) is a severe disease with limited treatment options. This report reviews our own and prior publis

Interferon-γ therapy in patients with refractory disseminated #coccidioidomycosis

Steve Holland and colleagues in @cidjournal.bsky.social

academic.oup.com/cid/advance-...

Economic Burden of Fungal Diseases in the United States We conservatively estimated the U.S. economic burden of fungal diseases as $11.5 billion in 2019: direct medical costs ($7.5 billion), productivity loss du

Benedict K. and colleagues estimate that the US fungal disease related economic burden to be 19.4 billion dollar (with Dr. Evil sound effect)!!!

academic.oup.com/ofid/article...

ISHAM Histoplasma working group

Saving the best for last, Histoplasma working group
ISHAM2025 Foz do Iguaçu, Brazil

Michael Mansour presenting

Michael Mansour presenting about "Augmenting neutrophil function as a therapeutic strategy for high risk-patients"
Next level stuff! @mansourlab.bsky.social @mgh-id.bsky.social

Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections | Clinical Microbiology Reviews SUMMARYAntibody and antigen detection assays continue to play a significant role in the diagnosis of dimorphic fungal pathogens, including Blastomyces dermatitidis complex, Coccidioides immitis/posada...

journals.asm.org/doi/10.1128/...

Great paper! @germhuntermd.bsky.social

AUC0-24/MIC for two different durations of antifungal treatment in ICU: 1-3 days vs 4-7 days, shown for various antifungals (and for caspofungin and anidulafungin shown separately for C albicans and C glabrata) PK/PD target-related exposures per occasion of the study antifungals prescribed for treatment. The shaded area represents the PK/PD target used in this study. For fluconazole, 15 data points are outside the y-axis limits (max AUC0-24/MIC value was 3250.3); ICU intensive care unit; AUC0-24 area under the plasma concentration-time curve from zero to 24 h; fAUC0-24 free AUC0-24; MIC minimum inhibitory concentration; Cmin minimum observed plasma concentration; Cmax maximum observed plasma concentration

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter PK study for Screening Antifungal Exposure in Intensive Care Units (SAFE-ICU)

J Roberts etc

TLDR: ++variable, need tailored approach w TDM

link.springer.com/article/10.1...

That's great news. Looking forward to it.

Histoplasmosis (2025)

Update on the Clinical Practice Guidelines for treatment of Histoplasmosis. Thank you to all the authors @fungaldoc.bsky.social @germhuntermd.bsky.social @jobadd.bsky.social @iddoc4kids.bsky.social Nathan Bahr

www.idsociety.org/practice-gui...

HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV Persons with HIV (PWH) are living longer, leading to increased end-organ disease from chronic illness. Organ transplantation improves survival in patients with end-organ disease yet remains a constrai...

From rising #TxID star (and a Canadian, no less), Patrick Tam @tamckpatrick.bsky.social

HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV

www.jhltopen.org/article/S295...

You are absolutely right, "screening" is not the appropriate word. I agree with more testing in patients with suspected histoplasmosis. However, prior studies do show a significant prevalence (~5%) in asymptomatic advanced HIV. Certainly, this is region specific and should not be generalized.

Histoplasmosis screening using urinary antigen detection in people living with HIV in Southern Brazil Abstract. Histoplasmosis is a life-threatening opportunistic infection in individuals with advanced HIV disease (AHD), particularly in endemic regions such

Histoplasmosis screening was positive in 9.1% of PLWHIV with clinical manifestations suggestive of histoplasmosis (including fever, night sweats and weight loss) in a Brazilian center. More screening is required for early diagnosis and improved outcomes.

academic.oup.com/mmy/advance-...

Investigating Asthma After Coccidioidomycosis Among Patients With Commercial Health Insurance, United States, 2017–2022 Background The relationship between asthma and coccidioidomycosis has not been fully described. We have hypothesised that Coccidioides could trigger inflammatory airway responses, similar to other f...

Fungal sensitization syndrome may be more prevalent than currently thought. This article examines asthma as a potential coccidiodiomycosis complication.

onlinelibrary.wiley.com/doi/10.1111/...

Immune Monitoring Assays: Predicting Cytomegalovirus and... : Transplantation An abstract is unavailable.

If it's written by @kottonnelson.bsky.social, it is a must read!

Concise expert insight into the utility of Immune monitoring assays for Cytomegalovirus.

journals.lww.com/transplantjo...

Complement and fungal diseases - PubMed Complement and fungal diseases

What an amazing valentines gift!

pubmed.ncbi.nlm.nih.gov/39956284/

Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidias...

A must read...amazing collaboration between different societies

Super good article. Plus it has Michael K. Mansour @mansourlab.bsky.social as an author, boom!!

www.thelancet.com/journals/lan...

Retrospective Investigation of Pediatric Histoplasmosis Diagnosed at a Tertiary Children’s Hospital in an Endemic Area over 11 years AbstractBackground. Most histoplasmosis data are from adults. We describe pediatric histoplasmosis diagnosed at a tertiary pediatric care center in an ende

One of the largest reports on pediatric histoplasmosis.

academic.oup.com/jpids/advanc...

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis: First, Do No Harm Abstract. Antibiotic prophylaxis for spontaneous bacterial peritonitis (SBPPr) in patients with cirrhosis has been considered standard of care since the 19

This is a great commentary challenging the use of antibiotics for SBP prophylaxis in patients with cirrhosis.

academic.oup.com/cid/advance-...

I've added this review article by @arunasubramanian.bsky.social as it provides context to the question (great read).

journals.lww.com/hepcomm/full...

Friend or Foe? Safety and Efficacy of Hepatitis B Viremic... : Journal of the American College of Surgeons T+ and NAT-negative (–) allografts in seronegative recipients. Study Design: All recipients of an HBV core antibody-positive (HBcAb+) LT or KT were prospectively evaluated at a single transplant ce...

Expanding our pool (and knowledge)
Great article about the long term outcome of HBV viremic allograft use in seronegative liver and kidney transplant recipients.

journals.lww.com/journalacs/a...

Breakthrough Invasive Mold Infections in Hematologic Cases: Relevance of the Host's Factors This retrospective study evaluating breakthrough invasive mould infections occurring among hematological patients highlights that host factors, including p

Two good reads to accompany the Saturday morning coffee:

doi.org/10.1093/ofid... (Breakthrough invasive mold infections in hematological cases)

academic.oup.com/ofid/article...
(Adenovirus incidence on pediatric SOT)

a baby anna from the movie frozen is surrounded by snow Alt: a baby anna from the movie frozen is surrounded by snow

Fun things to read and keep us entertained during these difficult times.

"Surveillance and prevention of infection in clinical xenotransplantation"

journals.asm.org/doi/10.1128/...

Amazing article by Adam Stewart and Jay Fishman

Check out our editorial "Beyond the test: moving forward with transplant candidates testing positive for COVID-19"

Since I wrote it with @kottonnelson.bsky.social, can I say that I'm a grownup, or not just yet?

We discuss an interesting Transplantation article:

journals.lww.com/transplantjo...

What an awesome start for cocci this 2025!

Outcomes of cocci in Ab+ SOTs after stopping antifungal prophy
journals.lww.com/transplantjo...

Antifungal prophy for Cocci: how long
journals.lww.com/transplantjo...

Should we treat mild cocci in immunocompetent host
academic.oup.com/cid/advance-...

Journal of Fungi review of #Histoplasmosis in solid organ #transplant by @nicobarrosid.bsky.social and L. Joseph Wheat of MiraVista Labs

🚨Open access🚨
🔥Great tables!🔥

Open Access articles always prioritized by transplantid.net

https://buff.ly/4aovOY7

Corticosteroids for Sepsis, ARDS, or Community-Acquired Pneumonia This JAMA Clinical Guidelines Synopsis summarizes the 2024 Society of Critical Care Medicine guidelines on use of corticosteroids in sepsis, acute respiratory distress syndrome, and community-acquired...

This guideline sought to provide updated recommendations on corticosteroid use for adults with sepsis, ARDS, and CAP

jamanetwork.com/journals/jam...