The Lancet Gastroenterology & Hepatology

Our January 2026 issue is out now: www.thelancet.com/gastrohep

Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more!

#GastroSky #MedSky #IBDSky

Best practice guidelines for viral hepatitis service delivery in prisons Viral hepatitis constitutes a major health burden among people living in prison globally. There is poor access to prison-based viral hepatitis services, and people living in prison are rarely prioriti...

New Review

Best practice guidelines for viral hepatitis service delivery in prisons

www.thelancet.com/journals/lan...

Tinengotinib for adults with advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 trial These findings suggest that tinengotinib might have activity in patients with cholangiocarcinoma with FGFR2 fusions that progressed following FGFR inhibitor therapy. Anti-tumour activity was also obse...

New research - Tinengotinib for adults with advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 trial

www.thelancet.com/journals/lan...

#OncSky #GastroSky @oncoalert.bsky.social rt

New research - Glecirasib with or without cetuximab in previously treated locally advanced or metastatic colorectal cancer with KRASG12Cmutation (JAB-21822-1002 and JAB-21822-1007): two open-label, non-randomised phase 1/2 trials

www.thelancet.com/journals/lan...

#GastroSky #OncSky #MedSky

New research - Adjuvant camrelizumab combined with capecitabine in patients with intrahepatic cholangiocarcinoma after surgical resection in China (ACC): a single-arm, single-centre, open-label, phase 2 trial

www.thelancet.com/journals/lan...

#GastroSky #LiverSky #OncSky #MedSky

Closing the Middle East and north Africa representation gap in clinical trials in inflammatory bowel disease Inflammatory bowel disease (IBD) has expanded beyond its initial confines of early industrialised countries in North America, Europe, and Oceania and now constitutes a global illness. Once rare in the...

New Comment - Closing the Middle East and north Africa representation gap in clinical trials in inflammatory bowel disease

www.thelancet.com/journals/lan...

#GastroSky #MedSky #IBDSky

🚨Our Dec issue is live! - thelancet.com/issue/S1470-...

📊Articles: #lungcancer, #breastcancer, #hepatocellularcarcinoma, #rectalcancer, #glioma

📑Reviews including neurocognitive outcomes in patients with brain metastases AND SISAQOL-IMI consensus guidelines on PROs in trials

Efficacy and safety of mirikizumab in paediatric participants with moderately-to-severely active ulcerative colitis (SHINE-1): a multicentre, open-label, non-randomised phase 2 trial Mirikizumab exhibited safety and efficacy in paediatric participants with moderately-to-severely active ulcerative colitis. These results support further evaluation of mirikizumab in the paediatric po...

New research - Efficacy and safety of mirikizumab in paediatric participants with moderately-to-severely active ulcerative colitis (SHINE-1): a multicentre, open-label, non-randomised phase 2 trial

www.thelancet.com/journals/lan...

#GastroSky #MedSky #IBDSky

A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities Treatment efficacy in similar WH and SA IBD patients recruited to the UK IBD BioResource is unaffected by ethnicity but patients from SA ethnic backgrounds are at increased risk of developing pancreat...

New research @eClinicalMed - A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities

www.thelancet.com/journals/ecl...

#GastroSky #MedSky #IBDSky

Preprocedural screening for multidrug-resistant organisms in endoscopic retrograde cholangiopancreatography: an international, multicentre, cross-sectional observational study This study shows global heterogeneity in MDRO carriage among patients undergoing ERCP, reflecting underlying differences in antimicrobial resistance, healthcare infrastructure, and infection control p...

New @eclinicalmed.bsky.social - Preprocedural screening for multidrug-resistant organisms in endoscopic retrograde cholangiopancreatography: an international, multicentre, cross-sectional observational study

www.thelancet.com/journals/ecl...

#GastroSky #MedSky #IDSky #MicroSky

Effects of glucagon-like peptide-1 receptor agonists on alcohol consumption: a systematic review and meta-analysis GLP-1 RAs, particularly Semaglutide and liraglutide, reduce alcohol use as measured by AUDIT scores and show beneficial effects on consumption, relapse, and alcohol-related morbidity. Mechanistic evid...

New @eClinicalMed - Effects of glucagon-like peptide-1 receptor agonists on alcohol consumption: a systematic review and meta-analysis

www.thelancet.com/journals/ecl...

#GastroSky #MedSky #EndoSky

Development and validation of a machine-learning model to reduce futile procurements in donations after circulatory death in liver transplantation in the USA: a multicentre study We show that, compared with surgeon predictions and existing risk-prediction tools, our machine-learning model can enhance the accuracy of the prediction of progression to death in DCD donors and redu...

New at The Lancet Digital Health - Development and validation of a machine-learning model to reduce futile procurements in donations after circulatory death in liver transplantation in the USA: a multicentre study

www.thelancet.com/journals/lan...

#LiverSky #MedSky

Figure: Interaction between different levels of drinking in crisis situations. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Despite their high prevalence, alcohol use disorders remain undertreated.

A recent Seminar discusses the need for integrated alcohol control policies to improve the prevention of alcohol use disorders, improve access to treatment, and reduce stigma: spkl.io/63324Abjiu

Blue graphic promoting a Lancet Webinar. Text saying: "Join Jian Zhou, Professor at Zhongshan Hospital, Fudan University, for our global webinar on global strategies to reverse the rise of liver cancer on Thursday, November 27, 2025 at 9am GMT/10am CET". A photograph of Professor Zhou appears on the right-side of the graphic. Copyright: Elsevier Ltd.

Liver cancer is the 6th most common cancer globally.

Join our webinar exploring The Lancet's Commission on addressing the global liver cancer burden and its comprehensive strategies from prevention to treatment.

👉 Register: hubs.li/Q03GK-q50

#oncology #hepatology #lgcw2025

The Lancet Summit: shaping the future of diabetes prevention. Image credit: Ixefra / Getty Images.

📣 Big news! We’re excited to announce the Advisory Board for The #LancetSummit: shaping the future of #diabetes prevention. Welcome Amanda Adler, Kamlesh Khunti, Dianna Magliano, Chantal Mathieu and Didac Mauricio Puente. Find out more and submit your abstract to join the Summit: hubs.li/Q03MV20T0

A special preview issue of The Lancet Regional Health – Africa. On the cover is a photograph of a doctor examining a Maasai baby. Copyright: Hugh Sitton/Getty Images.

🔔 Introducing The Lancet Regional Health – Africa, a new #goldopenaccess journal promoting the advancement of clinical practice and health policy in Africa.

Explore the new journal: ➡️ spkl.io/63325AbmLD #MedSky

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study Pemvidutide treatment met the primary endpoint of MASH resolution without worsening of fibrosis at 24 weeks but did not meet the other primary endpoint of fibrosis improvement without worsening of MAS...

New @thelancet.com - Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study

www.thelancet.com/journals/lan...

#LiverSky #MedSky #EndoSky

Cover of the November issue of The Lancet Microbe

Our November issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #HTLV-1 #AMR #Lassa #Neisseria #gonorrhoea #tuberculosis #TB #influenza

#IDSky #ClinMicro #OA

Alt-text: The cover of The Lancet Obstetrics, Gynaecology, & Women’s Health which features artwork of a woman curled around, holding her abdomen due to pain from endometriosis. The world map is visible in the background. Copyright: Cover image by Elizabeth Sanduvete Chaves.

Endometriosis affects around 190 million women and girls globally. Despite progress, the exact causes remain unknown.

The latest issue of @lancetobgyn-wh.bsky.social features articles on advancements & the research still needed.

🔗 : tinyurl.com/4by2evfs

NEW RESEARCH—IgG4-related disease in the Japanese population: a whole-genome sequencing study bit.ly/4oVaGPm

Plus, linked Comment bit.ly/4hOOOmz
#Medsky #Rheumsky

Our December issue is out now at www.thelancet.com/journals/lan...

Content includes diet in GI disorders; IBS; IBD; oesophageal cancer; alcohol-related liver disease; MASLD + more!

#GastroSky #LiverSky #MedSky

Blue graphic with text saying: "The Lancet Webinars. Join our global webinar on the global strategies to reverse the rise of liver cancer on Thursday, November 27, 2025 at 9am GMT/10am CET. An image of a red liver in a blue body appears on the right of the graphic in a hexagonal frame. Copyright: Elsevier Ltd.

What if we could work together to change the future of liver cancer?

Join our webinar exploring how we can tackle the rising trend of liver cancer and differences in disease management across regions, hosted as part of London Global Cancer Week.

📆 Nov 27, 9am GMT
👉 Register: hubs.li/Q03GK-q50

Non-coeliac gluten sensitivity Non-coeliac gluten sensitivity (NCGS) refers to individuals who report intestinal and extraintestinal symptoms related to the ingestion of gluten-based or wheat-based foods, in the absence of coeliac ...

Non-coeliac gluten sensitivity (NCGS) remains a highly debated condition, despite ~10% of the global population self-reporting a gluten or wheat sensitivity.

A new Review examines current evidence & provides practical guidance for assessment and management: tinyurl.com/yjafmhc5

🚨Our Nov issue is live - thelancet.com/issue/S1470-...

📊Articles: #breastcancer, #NSCLC, #prostatecancer, #melanoma

📰 Reviews: Tumour-infiltrating lymphocyte therapy in the era of genetic engineering AND AI for Response Assessment in Pediatric Neuro-Oncology (AI-RAPNO)

Cilofexor in non-cirrhotic primary sclerosing cholangitis (PRIMIS): a randomised, double-blind, multicentre, placebo-controlled, phase 3 trial Cilofexor did not significantly reduce the rate of fibrosis progression (vs placebo) in participants with non-cirrhotic PSC. A greater percentage of cilofexor-treated participants had pruritus than pl...

New research - Cilofexor in non-cirrhotic primary sclerosing cholangitis (PRIMIS): a randomised, double-blind, multicentre, placebo-controlled, phase 3 trial

www.thelancet.com/journals/lan...

#LiverSky #MedSky

Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial Linerixibat significantly improved pruritus versus placebo, supporting its potential to address a major symptom of PBC. An expected increase in diarrhoea in linerixibat-treated patients was observed.

New research - Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial

www.thelancet.com/journals/lan...

#LiverSky #MedSky

New research - Vedolizumab in early and late Crohn's disease (LOVE-CD): a phase 4 open-label cohort study

www.thelancet.com/journals/lan...

#GastroSky #MedSky

Our November issue is live!

Including research on hip #osteoarthritis, #JIA, #BackPain, and #PsoriaticArthritis, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

Fatigue in people with primary biliary cholangitis: a position paper from the European Reference Network for Rare Liver Diseases Given the unmet need of fatigue in primary biliary cholangitis (PBC), the PBC working group of the European Reference Network for Rare Liver Diseases assessed and summarised the current evidence relat...

New Review - Fatigue in people with primary biliary cholangitis: a position paper from the European Reference Network for Rare Liver Diseases

www.thelancet.com/journals/lan...

#LiverSky #MedSky

New research - Thoracoscopic versus open oesophagectomy for patients with oesophageal cancer (JCOG1409 MONET): a multicentre, open-label, randomised, controlled, phase 3, non-inferiority trial

www.thelancet.com/journals/lan...

#GastroSky #MedSky #OncSky