The Lancet Gastroenterology & Hepatology

The full ENDURO report has just been published at @LancetGastroHep - www.thelancet.com/journals/lan...

#GastroSky #MedSky #UEGWeek

Palliative treatment with endoscopic gastroenterostomy was superior to surgical gastroenterostomy for time to resumption of solid oral intake and was non-inferior for the rate of persistent or recurrent obstructive symptoms requiring re-intervention

#GastroSky #MedSky #UEGWeek

Opening plenary time at #UEGWeek!

The first research of the session is presented by Yorick van de Pavert, with the ENDURO trial of endoscopic versus surgical gastroenterostomy for palliation of malignant gastric outlet obstruction

#GastroSky #MedSky

Let’s go…

#UEGWeek #GastroSky #MedSky

🚨Our Oct issue is live -
thelancet.com/issue/S1470-...

📈Articles: on #RCC, #SCLC, #NSCLC, #BladderCancer, #Myeloma, #PancreaticCancer,
#EndometrialCancer, and #ThyroidCancer

📝Reviews: EU–CAYAS–NET recommendations for health-care transitions in young people beyond
childhood cancer

A special preview issue of The Lancet Regional Health – Africa. On the cover is a photograph of a doctor examining a Maasai baby. Copyright: Hugh Sitton/Getty Images

🔔 Introducing The Lancet Regional Health – Africa, a new #goldopenaccess journal promoting the advancement of clinical practice and health policy in Africa.

Explore the new journal at hubs.li/Q03KzMp00 #MedSky

Hepatitis B Foundation & ICE-HBV are co-hosting a moderated panel discussion on the rationale for expanded & early treatment of hepatitis B.

It covers two recent co-authored papers published in @lancetgastrohep.bsky.social & our WPRO Board Member, Thomas Tu, is a panelist.

Register: bit.ly/46NSW0O

Etrasimod as induction and maintenance treatment for patients with moderately to severely active ulcerative colitis in East Asia (ENLIGHT UC): a randomised, double-blind, placebo-controlled, multicent... Etrasimod was effective and well tolerated as an oral induction and maintenance treatment in patients with moderately to severely active ulcerative colitis in East Asia.

New research - Etrasimod as induction and maintenance treatment for patients with moderately to severely active ulcerative colitis in East Asia (ENLIGHT UC): a phase 3 study

www.thelancet.com/journals/lan...

#GastroSKy #MedSky #IBD @lancetgastrohep.bsky.social

Flyer for webinar on hepatitis B treatment, scheduled for Oct 23 205 4pm EDT.

Scientific, public health & lived experience rationale for expanding #hepatitis B treatment.
Webinar hosted by @ice-hbv.bsky.social & #HepatitisBFoundation.
Details in flyer 👇
#HBV #HepSky #LiverSky #MedSky 🧪💊🌍
@suwang88.bsky.social
@lancetgastrohep.bsky.social
www.hepb.org

I'll be at #UEGWeek in Berlin October 5-7! If you'd like to discuss your research or ideas for reviews or opinion pieces, or just catch up over a coffee, please drop me a line!

#gastroenterology #UEGWeek2025

New @lancetgastrohep.bsky.social

Non-inferiority of lyophilised faecal filtrate vs lyophilised donor stool was not established for the prevention of C difficile recurrence over 8 weeks

👉 Live 🦠 crucial in mediating clinical efficacy

www.thelancet.com/journals/lan...

#GISky #IDSky #MicroSky #FMT

Fecal filtrate is less effective than donor stool (FMT) for the treatment of C. difficile recurrence. Now shown in a multicentre trial, out today in @lancetgastrohep.bsky.social .

Congratulations to Dina Kao @ualberta.bsky.social & team!

Gift link:

authors.elsevier.com/c/1lphg8nByr...

The Hepatitis B Vaccine Is Under Threat. Here’s What to Know.

The ACIP meeting is Sept 9/18-9/19 and the hepatitis B vaccine is at stake.
www.nytimes.com/2025/09/16/w...

@altcdc.altgov.info @worldhepalliance.bsky.social
@lancetgastrohep.bsky.social @altfda.altgov.info @aasldnews.bsky.social #IDsky #Liversky

Risk of hepatic and extrahepatic outcomes associated with metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated steatotic liver disease: a systemati... MetALD might be associated with a higher risk of liver-related events, hepatocellular carcinoma, and extrahepatic cancers than MASLD, whereas all-cause mortality, extrahepatic cancer-related mortality...

New research - Risk of hepatic and extrahepatic outcomes associated with metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction and alcohol-associated steatotic liver disease: a systematic review & meta-analysis

www.thelancet.com/journals/lan...

#LiverSky #MedSky

🚨Our Sept issue is live - 25 years! thelancet.com/journals/lan...

📊Articles #renalcellcarcinoma, #prostatecancer, #meningioma, #thymiccarcinoma, & #colorectalcancer

Reviews: 📰 ESTRO and ASTRO plus endorsed guidelines on vol delineation & 📰 Common Sense Oncology and EORTC on reporting QoL data

Figure showing the immunopathogenesis of Shigella infection in the colon. MAMPs=microbe-associated molecular patterns. DAMPs=damage-associated molecular patterns. NK=natural killer. Adapted from Schnupf and Sansonetti. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Shigellosis is the most common cause of invasive bloody diarrhoea in children younger than 5 years.

The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.

Find out more ▶️ tinyurl.com/ard69t83

New research - Phosphatidylethanol and self-reported alcohol intake to subclassify in individuals at risk of steatotic liver disease: an analysis of data from a prospective cohort study

www.thelancet.com/journals/lan...

#LiverSky #MedSky @aleksanderkrag.bsky.social @israelsenm.bsky.social

Phosphatidylethanol and self-reported alcohol intake to subclassify in individuals at risk of steatotic liver disease: an analysis of data from a prospective cohort study Phosphatidylethanol is a direct biomarker of alcohol consumption within the past 1–4 weeks, making it a potential tool in the subclassification of pat…

How should we use PEth in SLD care? 🩸🍺

Our study in @lancetgastrohep.bsky.social (n≈3,000) shows:
🔍 39% of MASLD → MetALD/ALD with PEth
⨻ Triangulating self-report + AUDIT-C + PEth = better classification
⚖️ But 40% get no added value → use selectively

www.sciencedirect.com/science/arti...

Our October Issue is now online, featuring prediabetes remission, obesity, type 1 diabetes, biased GLP-1 receptor agonists, type 2 diabetes, prolactin-secreting adenomas, malnutrition-related diabetes, food system, NCDs & much more www.thelancet.com/journals/lan...

#MedSky #EndoSky #OncSky

Hypothalamic obesity: from basic mechanisms to clinical perspectives Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the important contribution of brain circuits to this condition. The hypothalamus c...

Although very infrequent, cases of #hypothalamic #obesity are a challenging, often intractable medical condition, that can also help to elucidate mechanisms of obesity and eventually identify therapeutic targets www.thelancet.com/journals/lan...
#hyperphagia

#MedSky #EndoSky

People with #MASLD can progress to cirrhosis and hepatocellular carcinoma and are at increased risk of developing type 2 #diabetes, #cardiovascular disease, chronic #kidney disease, and extrahepatic #cancers www.thelancet.com/journals/lan...
#T2D #CVD #CKD
#OpenAccess

#MedSky #EndoSky #LiverSky

@thelancetoncol.bsky.social is pleased to announce we are partnering with @estroradiotherapy.bsky.social and Radiotherapy and Oncology for a second year at next year’s Congress in Stockholm. Please submit your abstracts!

www.estro.org/Congresses/E...

Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".

Our September issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella

#IDSky #ClinMicro #OA

The October issue of @LancetGastroHep is now available at thelancet.com/gastrohep!

Includes content on #AI, colonoscopy, inflammatory bowel disease, MASLD, viral hepatitis, and more...

#GastroSky #IBDSky #HepSky #MedSky

Descriptive epidemiology of age at colorectal cancer diagnosis in Africa: a systematic review and meta-analysis

While the incidence of CRC is still low in Africa, there is younger age at diagnosis and overall high proportion of EOCRC

www.thelancet.com/journals/ecl...
#ColorectalCancer #MedSky

Credit: Adria Volta

📰The Lancet Respiratory Medicine’s September issue is out now

Read content on obstructive sleep apnoea, #tuberculosis, cardiogenic shock, #pneumonia, and much more

Check out the full issue here: bit.ly/3P2PVls

Oct 2025 Volume 9 Number 10 p685-752 Cover image by Jhoan Mosquera Suarez, age 6 years. A rainbow and apple tree overlook mountains and sea.

Our October 2025 issue is now live with content on #consent in #neonatal #clinicaltrials, growth trajectories in #twins, an #RCT on #CPAP delivery in #preterm #infants, & more

Read the full issue here👉 bit.ly/3JDzc8t

#MedSky #PedSky

Overlooked determinants and unequal outcomes: rethinking metabolic dysfunction-associated steatotic liver disease beyond the biomedical model Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a public health priority due to its high prevalence, silent clinical course, and liver and systemic outcomes. With an es...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide.

In @lancetgastrohep.bsky.social, a Personal View proposes a comprehensive and multisectoral approach for the sustainable management of MASLD: tinyurl.com/mrcdcept

The psychobiological model of disorders of gut–brain interaction

New Personal View - The psychobiological model of disorders of gut–brain interaction: introduction of a novel, integrated, and testable model

www.thelancet.com/journals/lan...

#GISky #MedSky @romegastropsych.bsky.social

Targeting alcohol use in high-risk population groups: a US microsimulation study of beverage-specific pricing policies Disproportionate increases in retail prices for the cheapest beverages, beer and spirits, might lead to a greater decline in consumption among high-risk groups. Pricing policies could thus be used as ...

New at The Lancet Public Health - Targeting alcohol use in high-risk population groups: a US microsimulation study of beverage-specific pricing policies

www.thelancet.com/journals/lan...

#alcohol #LiverSky #MedSky