Low carb for the metabolically unhealthy | Bill Lagakos Get more from Bill Lagakos on Patreon

Low carb for the metabolically unhealthy www.patreon.com/posts/143273...
New blog post

Current TV shows I’m watching rn: Pluribus, The Chair Company, Robin Hood, Mayor of Kingstown

Too soon to give reviews, although I liked prior seasons of Mayor of Kingstown

You? Any of these or any others?

The smartest people on the planet couldn't make Biosphere 2 work

Good luck colonizing Mars

Shout out to everyone who makes an effort to get 10k steps a day 👏👏

Fuel 'preference' during high intensity physical activity | Bill Lagakos Get more from Bill Lagakos on Patreon

Fuel 'preference' during high intensity physical activity www.patreon.com/posts/141225...
new blog post

It's Always Sunny In Philadelphia

Charlie likes his grilled cheese this way:

Cheese & butter on the inside, peanut butter on top 🤌

Interested in intermittent fasting or time-restricted feeding?

Make it early time-restricted eating and may experience benefits beyond an energy deficit

Improved sleep quality and everything downstream from that, which is seemingly endless

1 BTC = $123480 = 100000000 satoshi

$1 = 0.0000081 BTC = 810 satoshi

1 satoshi = $0.0012 = 0.00000001 BTC

Outcome data is used to critique and correct mechanistic data

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

www.nejm.org/doi/full/10....

Carbs don't cause insulin resistance, the condition in which a carb bolus would actually cause hyperglycemia

But to reiterate, carbs don't cause insulin resistance

Zero pro bodybuilders do a ketogenic diet in the offseason when they're trying to gain muscle while minimizing fat gain

Collagen is trending again 👍

Remember: it's *in addition to* your habitual protein intake, not *instead of*

Creatine should be classified as a macronutrient

If you time it right, you can take 5 grams of creatine every 8 hours

Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need? Vitamin D is the sunshine vitamin for good reason. During exposure to sunlight, the ultraviolet B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized...

"There needs to be a renewed appreciation of the beneficial effect of moderate sensible sunlight for providing all humans with their vitamin D requirement for health" link.springer.com/chapter/10.1...

☀️ > vitamin D

Potatoes Compared with Rice in Meals with either Animal or Plant Protein Reduce Postprandial Glycemia and Increase Satiety in Healthy Adults: A Randomized Crossover Study - PubMed gov/prs/app/action/SelectProtocol?sid=S000CKIJ&selectaction=Edit&uid=U0000IA4&ts=2&cx=-uf51kf) as NCT05610124. Protocol ID: 43406 (Postprandial Glycemia and Satiety of Meals with Potatoes, with and wi...

Compared to rice, both instant mashed potatoes and baked French fries caused more satiety and less food intake at a follow-up meal pubmed.ncbi.nlm.nih.gov/39182847/

Keto arteries O_O

The new seed oil goal posts - thresholds & saturation  | Bill Lagakos Get more from Bill Lagakos on Patreon

The new seed oil goal posts - thresholds & saturation

www.patreon.com/posts/133971...
New blog post

Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being Abstract. Smartphones enable people to access the online world from anywhere at any time. Despite the benefits of this technology, there is growing concern

Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being academic.oup.com/pnasnexus/ar...

The Church of Perpetual Ketosis

Day and night light exposure are associated with psychiatric disorders: an objective light study in >85,000 people - Nature Mental Health Burns et al. explored the association between day and night-time light exposure and the risk for psychiatric disorders using a large sample of adults from the UK Biobank dataset.

"Avoiding light at night and seeking light during the day may be a simple and effective, non-pharmacological means of broadly improving mental health" www.nature.com/articles/s44...

The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose - Psychopharmacology Rationale Disturbances of the circadian system are common in depression. Though they typically subside when depression is treated with antidepressants, the mechanism by which this occurs is unknown. D...

How you gonna treat a mood disorder with something that causes circadian arrhythmia?

Celexa suppresses melatonin

If you're on an SSRI for any reason, pay extra attention to light hygiene (morning sunlight, blue blockers at night, sleep mask) link.springer.com/article/10.1...

The sugar diet | Bill Lagakos Get more from Bill Lagakos on Patreon

The Sugar Diet - new blog post www.patreon.com/posts/132483...

Anti-ketogenic | Bill Lagakos Get more from Bill Lagakos on Patreon

How do you explain people being anti-ketogenic? New blog post www.patreon.com/posts/anti-k...

New season of The Bear drops in 2 weeks

Every season has ups and downs but generally net good

Will be watching

Marinara caper vege dip Great for roasted vegetables

Marinara caper vege dip caloriesproper.substack.com/p/marinara-c...

On one hand, epi studies show plenty of lean cannabis users; the munchies don't cause obesity (?)

On the other hand, Rimonabant causes weight loss; blocking the munchies reduces food intake

Better sleep without drugs: How cognitive behavioral therapy for insomnia works Better sleep without drugs: How cognitive behavioral therapy for insomnia works

CBTi isn't fool-proof but it's better than any drug for improving long-term sleep quality www.uab.edu/news/news-yo...

The dark side of light: light at night may raise the risk of type 2 diabetes Thanks to Thomas Edison (1847–1931), who invented practical incandescent light bulbs in 1879, light at night has become a ubiquitous feature of modern society.1 Light at night, indoors and outdoors, e...

The dark side of light: light at night may raise the risk of type 2 diabetes www.thelancet.com/journals/lan...