Bush Lab

Historically, "Standard Grants" were not fully funded at the time of award. NSF would first fund only the first year and then fully fund a subset of awards near the end of the fiscal year. When new, limited duration funds became available, NSF would fully fund even more awards..

Depending on how you are managing this data, I recommend trying to track changes in "Total Awarded Amount to Date" throughout the year. NSF often makes awards that initially fund only the first year, but then will pre-fund the remaining years of some awards near the end of the fiscal year.

I am also interested in seeing this with "Total Intended Award Amount" and/or "Total Awarded Amount to Date" on the vertical axis. "Number of Awards" is likely more informative overall, amounts would apply different weighting to small awards (e.g., conference grants).

Our new instrument lab. Many thanks to Addison Roush and Chris Weir for all of their efforts over winter break!

A telehandler moving a crate containing our Cyclic IMS system. Many thanks to UW Facilities!

Over the holidays, we relocated our mass spectrometers to Bagley Hall in preparation for the construction of a new Chemical Sciences Building. Many thanks to graduate students Addison Roush and Chris Weir for all of their contributions over the last two weeks!

NSF pares down grant-review process, reducing influence of outside scientists Memo cites overburdened staff, but some say move also aims to elevate White House priorities

NSF plans to streamline merit review to heal self-inflicted staffing wound www.science.org/content/arti...

Thanks for highlighting! I'm going to share a set of nice photos that I'll make available for teaching. My aspirational plan is to write questions for each artifact (like those for the QTOF), but I ran out of time before the workshop. I'll also post photos to bsky and crowd source ideas!

I've only witnessed it once before, but it left an indelible mark on my soul. Required extensive cleaning of two chambers and replacement of ion guides. There are ways to avoid this outcome (backfilling with nitrogen and closing valves.) For our research, I will continue usin oil free pumps.

Past Recipients - American Chemical Society American Chemical Society: Chemistry for Life.

Past award recipients: www.acs.org/funding/awar...

@asms.org @garcialabms.bsky.social @joelooucla.bsky.social @jyates.bsky.social Please repost - thanks!

Division of Analytical Chemistry Awards Visit the post for more.

The Field and Franklin Award for Mass Spectrometry is back! Since 1985, this award has recognize outstanding achievement in the development or application of #massspec #teammassspec. Please submit nominations by November 14! Nomination details: acsanalytical.org/awards-resou...

I will cite this paper more going forward. What happened with the original submission? @goodlettlabb.bsky.social name appears correct in the PDF from 1994 - was the incorrect spelling submitted to Chemical Abstract Services or the like?

Registration is still open for a couple more days. Will be an exciting and informative two days! Feel free to DM or email Matt Bush with any questions. #teammassspec

Does anyone in the USA have a crate for a Waters Cyclic or Waters Synapt XS that they are willing to give or lend to me?

Concur! Parquet is great. We've been impressed using Parquet for other projects, including integrating results from many ion mobility experiments, where we need to track and index lots of metadata, and logging ion trajectory simulations, where we need compression, read speed, and durability.

Calculating the COM collision energy under those conditions sounds like a great question for a problem set! Thanks for sharing.

Congratulations to AnneClaire Wageman, Addison Roush, and Bruce Feng! SLIMPHONY is enabling exciting new research that we look forward to reporting in the months and years ahead.

Excited to share a new paper! SLIMPHONY uses eight independently controlled traveling-wave regions that work in concert to select and activate ions in multiple regions, to vary the number of dimensions of ion mobility, and to control the length of ion mobility separations. doi.org/10.1021/jasm...

A fuse or breaker on the instrument should pop before the breaker in the panel. None of these systems are infallible, so the breaker mitigates worst case scenarios (eg, electrical fire). I have run systems as you are proposing (15A system on 20A or 30A circuit), but I try to correct that situation.

A mass spectrometer should be on its own circuit (i.e., a dedicated breaker). Swapping to a lower amp breaker on an existing circuit is easy (say 2-5 minutes), but usually requires powering off the entire panel. If you have the electrician save the original breaker, also easy to revert.

I think it is worth having an electrician swap out the 30 A breaker for a 15 A breaker. Should be very low cost (<$100, even at university). If something goes really wrong (bearings sieze on pump, arcing on control board), the correct breaker will help manage the severity).

In USA, another aspect is single phase versus three phase for 208 V.

Sadly, the NSF MRI program is not accepting proposals this year. Hopefully this is only a one-year interruption to this program, which is critical to building the infrastructure to train scientist and engineers in the United States. www.nsf.gov/funding/oppo... | www.nsf.gov/funding/oppo...

Track records for using and sustaining instruments are evaluated carefully during proposal review. The program seeks to support long-term, stable, and sustainable instruments for research. A major concern is the possibility of instruments falling out of operation after initial service contract.

Interested in acquiring mass spectrometers through the NSF MRI program? @jaygforsythe.bsky.social greatly strengthened his proposal by reporting heavy use of a functionally obsolete system (RIP Voyager) that he sustained by "replac[ing] a few parts (turbo pump, ion gauges, vacuum control box)."

Great perspective on starting and sustaining a career at a primarily undergraduate institution (PUI) with research using instrumentation. Thanks for writing this, @jaygforsythe.bsky.social

Fear and loathing on study section: Reviewing grant proposals while the system is burning As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.

i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now

www.thetransmitter.org/craft-and-ca...

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

Application Requirements - Healthy Aging and Longevity Research Institute BMHA Training Program Application Procedures We invite applications from individuals who are interested in being considered for this program. Please note that all trainees in this program must be elig...

Our Biological Mechanisms of Healthy Aging Program is enthusiastic to share that we have 3 predoctoral and 3 postdoctoral openings for our T32 program with a start date of 8/15/2025. Applications are due to Rose Anderson at rosesa@uw.edu by 7/20/2025. halo.dlmp.uw.edu/bmha/applica...

Breaks my heart. I have also benefited greatly from the NSF MRI program — it is, without question, the best way for PUI chemists like me to get new instruments. Our schools can’t afford big startup or retention packages.

Alan Marshall: A scientist and a Gentleman - MagLab Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...