Daniela Cecalev

Happy to share the 2nd part of my PhD @natsmb.nature.com!

Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.

Check the Bluetorial by @eddaschulz.bsky.social 👇

06.10.2025 17:04 — 👍 20    🔁 4    💬 2    📌 0

Amazing work, Till!! Many congratulations 😊

08.10.2025 07:31 — 👍 1    🔁 0    💬 0    📌 0

WeTransfer TOS says they can use all your uploaded content for genAI

Bye forever, WeTransfer.

14.07.2025 23:57 — 👍 6950    🔁 3744    💬 213    📌 991

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

16.07.2025 15:23 — 👍 123    🔁 58    💬 10    📌 6

Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

14.05.2025 16:01 — 👍 98    🔁 38    💬 9    📌 4

It was such a fun night! 🤩

14.05.2025 11:44 — 👍 4    🔁 0    💬 0    📌 0

Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth

29.03.2025 12:45 — 👍 149    🔁 58    💬 6    📌 2

Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.

www.nature.com/articles/s41...

27.01.2025 14:49 — 👍 134    🔁 39    💬 7    📌 1

❗️A fantastic opportunity for Moldova🇲🇩
If you’re a researcher looking for funding, ERC grants can provide you with top financial support.
Don’t miss the chance to highlight your work and put Moldova on the global stage! 🌟

14.03.2025 13:47 — 👍 0    🔁 0    💬 0    📌 0

I am thrilled to share our latest work, released today 🤩

www-nature-com.insb.bib.cnrs.fr/articles/s41...

It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.

21.01.2025 10:34 — 👍 64    🔁 19    💬 12    📌 7

IMPRS PhD Program The IMPRS-EBM is an international PhD program that lies at the intersection of Epigenetics, Biophysics and Metabolism. It integrates strategies from molecular biology and biochemistry with biophysical...

I will soon be recruiting at all levels. Stay tuned for more updates soon!
🎓 We will recruit PhD students via the MPI-IE IMPRS PhD program this year www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
🚨 Deadline for application is February 28th🚨

16.01.2025 18:38 — 👍 14    🔁 7    💬 1    📌 0