Huang, Fei-Yang (黃飛揚)

Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...

RESEARCH | 🧪
M Cai, G Frost, C Edwards et al
@imperialcollegeldn.bsky.social @quadraminstitute.bsky.social ‬‬‬

This study compares how meals with contrasting cellular structures affect postprandial luminal metabolites, glycaemia, gut hormones and satiety sensation.

www.nature.com/articles/s42...

🚨New paper🚨

Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.

Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW

Thank you, Nils! Your talk is exciting, too! I am planning to combine neurostim with my recording soon. Your noninvasive approach seems promising for my exp! Would love to know more about the technology from you!

Thanks @ssibsociety.bsky.social fir the opportunity to share my research at my second SSIB conference. Loved the discussions with you all! #ssib2025

Great to have @ssibsociety.bsky.social in town! Please enjoy Oxford and hope to meet and discuss with you more in the coming days! (feel free to reach out if you need amy restaurant/pub advice!)

The countdown is on!

Who's headed to Oxford for #SSIB2025!

Join us for cutting-edge science, networking, and the historic charm of one of the world’s oldest universities.

Stay tuned for updates throughout the week. 🇬🇧

#IngestiveBehavior #Neuroscience #Oxford #SSIB

High-density, Identified Cell Recordings from Motor Cortex of Awake Behaving Macaques using 1024-channel SiNAPS-NHP Probes https://www.biorxiv.org/content/10.1101/2025.07.22.665434v1

Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity - Scientific Reports Scientific Reports - Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity

5-HT-mediated depolarization of OFC PV neurons occurs via activation of 2A, not 2C, receptors. And 2A antagonism works similarly in males and females www.nature.com/articles/s41...

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.

Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...

Daniel Cardozo Pinto: Decoding the Neural Circuitry of Reward Learning - Harvard University - Department of Molecular & Cellular Biology Daniel Cardozo Pinto, soon to be appointed a Harvard Junior Fellow, represents a compelling new voice in systems neuroscience. His research, grounded in a profound curiosity about the […]

Daniel Cardozo Pinto: Decoding the Neural Circuitry of Reward Learning 🧠🧪 #AcademicSky #higherEd
www.mcb.harvard.edu/department/n... @dcardozopinto.bsky.social @dulaclab.bsky.social @rachellegaudet.bsky.social @harvardbrainsci.bsky.social @naoshigeuchida.bsky.social @neurovenki.bsky.social

Unfortunately, I could not make it to GRC Amygdala this time. Hope to join you next year.

Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice - Nature Communications Striatal neural circuits control reward-associated behaviors but the role of astrocytes is still unclear. Here, the authors show that chemogenetic manipulation of striatal astrocyte in mice restore ob...

New publication out
Led by Enrica Montalban, who did a fantastic work, our new paper demonstrate a role for striatal astrocytes in the context of diet-induced obesity in both metabolic and cognitive processes. Thanks to all the collaborators for their work!

www.nature.com/articles/s41...

We had an incredible gathering at UK Neural Computation 2025 @imperialcollegeldn.bsky.social last week 🇬🇧 Macron missed out...

Some of the UK’s very best at the frontier of comp neuro.

Thanks to our sponsors ARIA + Crick & UKNC team: @markdhumphries.bsky.social + @neuralreckoning.bsky.social!

Complex negative emotions induced by electrical stimulation of the human hypothalamus Stimulation of the ventromedial hypothalamic region in animals has been reported to cause attack behavior labeled as sham-rage without offering information about the internal affective state of the an...

(buried in a reply, but) This is mind-blowing & deserves a post. Scroll to "video" in this article to watch what happens when the human hypothalamus is stimulated: it's a combo of embarrassment/shame and intense body sensations emanating from the heart. WOW.

www.brainstimjrnl.com/article/S193...

Resilient cortical maps - Nature Neuroscience Despite the loss of neurons during aging and the early stages of neurodegenerative disease, many cortical brain functions remain remarkably intact. Although this resilience is traditionally attributed...

Homeostasis can keep population-level responses stable in the face of neural drift and "vanishing neurons"

Nice write up of a paper I'm looking forward to reading but that seems to add more wood to the "populations are more than the sum of their neurons" fire

www.nature.com/articles/s41...

September will be here before you know it, so don't miss your chance to register for the 2025 @ieeebrain.bsky.social Discovery & Neurotechnology Workshop! This year's event will be held 12-13 Sep at @sfu.ca in beautiful #Vancouver, BC, Canada. Reserve your spot now at: cvent.me/VMXw00 #neurotech

Top left: Raster plot showing the neural spiking of different types of neurons across layers. The red dots represent excitatory neurons, while the others represent parvalbumin-positive interneurons (blue), somatostatin-positive interneurons (green), and 5-HT3a receptor-positive interneurons (purple), respectively. Top right: Averaged firing rate of excitatory neurons across layers over time, calculated using a 2 ms time bin. Dash lines indicate the onset of flash stimuli. Bottom: Schematic illustration explaining the phase dependency. The synaptic input from the lateral geniculate nucleus (LGN) enters the region adjacent to basal dendrites in deeper layers (gray circle), which are highly responsive to this input (left). When the peak phase of AC flows in a downward direction (middle), the membrane potential in basal dendrites is depolarized, leading to a weaker driving force. It results in weaker (less negative) excitatory postsynaptic current (EPSC) affecting change in LFPs and vice versa during the trough phase.

Electrical #BrainStimulation can be used to modulate #brain activity but how does it affect the #CorticalLayers? This study shows that only the deeper layers show phase-dependent changes in local field potential components upon electrical stimulation @plosbiology.org 🧪 plos.io/406W3i5

My first @ebbsociety.bsky.social experience in Bordeaux was fantastic! Thanks @ibroorg.bsky.social for the Young Investigator Award to make it happen. Really enjoyed the inspiring discussions with lovely friends. Hope to see you all soon!
@danasmall.bsky.social
@suzannedickson.bsky.social

Thank you, Alex! We should chat more in the coming days!

And now, the stage belongs to the young researchers with the Blitz Presentations of the Young Investigators Awar👏👏👏
#EBBS2025

Out today in @nature.com: we show that individual neurons have diverse tuning to a decision variable computed by the entire population, revealing a unifying geometric principle for the encoding of sensory and dynamic cognitive variables.
www.nature.com/articles/s41...

Enjoyed my first @rldmdublin2025.bsky.social so much! It’s so nice to talk to such a diverse and friendly group of computational/neuroscience/psychology people! Dublin is also fantastic. Love to come back next time!

A flexible hippocampal population code for experience relative to reward - Nature Neuroscience Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵

www.nature.com/articles/s41...

We had a great kick-off site visit with our NHP teams at the University of Pittsburgh, Carnegie Mellon University, and John Hopkins University! Thank you all so much for hosting us! @adamhantman.bsky.social @raeedcho.bsky.social @cmu.edu

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings:

www.biorxiv.org/content/10.1...

Computational characterization of metacognitive ability in subjective decision-making Metacognition is the process of reflecting on and controlling one's own thoughts and behaviors. Metacognitive ability is often measured through modeling the relationship between confidence reports and...

Preprint alert 🚨! Excited to share our new work on metacognition in value-based decision-making. www.biorxiv.org/cgi/content/.... We ask whether it is possible to derive a computational measure of metacognitive ability for economic preference choices.

YouTube video by The Theoretical Neuroscience Channel Back to the Continuous Attractor | Memming Park, Champalimaud Foundation

I saw this inspiring talk by @memming.bsky.social and thought that you shouldn't miss watching it either.
www.youtube.com/watch?v=kAY5...
🧠🤖
And here's the corresponding paper:
arxiv.org/pdf/2308.12585

#JNeurosci: ‪@stephanie-theves.bsky.social‬ proposes a novel approach to understanding human intelligence, emphasizing neural structure mapping—the brain’s process of abstracting and reasoning based on relational knowledge.
vist.ly/3n58cgk

Laying the Groundwork for Continuous Science - undefined Scientific work today is collaborative, computational, and evolving — yet we still communicate it through static, disconnected formats. Continuous Science Foundation is building a movement to reflect ...

Continuous Science Foundation is a new non-profit to advance tools, standards, and communities for iterative, integrated, collaborative, and continuous science.

articles.continuousfoundation.org/articles/gro...

Human eye on top, squirrel monkey eye below. Little of the peri-iridal tissues are exposed in the squirrel monkey, which is now understood to derive from simply scaling constraints and human adaptations to horizontal scanning. There is no evidence for social cognition being tied to such differences in eye appearances.

Due to the whites of the eye, humans have a uniquely communicative gaze. Other primates have dark eyes, hiding their gaze from conspecifics. We cooperate, they compete. Common knowledge – right? Yes, but it’s incorrect, as we argue in our new paper 🧵🧪1/11

onlinelibrary.wiley.com/doi/10.1111/...