Anthony Claude Antonelli

I am so grateful for this experience with them. So I hope you enjoy the work, and please reach out if you want to start asking cool questions about what's going on in the bone marrow for whatever you're studying!

Even after I left MSKCC to start a postdoc at @genentech.bsky.social, Andrew and Gil stepped up to heroically carry that torch across the finish line. This project was such a labor of love, and these people are not just fantastic mentors and colleagues, they're some of my best friends.

What resulted was a massive collaboration between not just me and my best friend, but virtually the entire Glickman and Steven Josefowicz labs, and this super cool story that I am so incredibly proud to have worked on.

"Huh, interesting," he said, "I wonder if it's inducing trained immunity in the myeloid compartment. You should look in the bone marrow."

Gil Redelman-Sidi and I were working on experiments showing that BCG - a live mycobacterial immunotherapy - induces an enhanced tumor-specific T cell response, upending the long-held belief that tumor elimination was simply the result of an immune response to BCG infection.

(Or were we already a beer deep after the match? My memory is a little hazy on this.)

Sometime in late 2018 I was telling @andrewdaman.bsky.social about my work in @michaelglickman.bsky.social’s lab at @mskcancercenter.bsky.social as we walked Manhattan's upper east side on our way to play a soccer match with the @weillcornell.bsky.social team.

Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity Daman et al. show that bladder administration of BCG, a microbial immunotherapy for bladder cancer, triggers a systemic immune response, reprogramming HSPCs and resulting in increased myeloid-driven a...

So happy to finally get this story out there!

www.cell.com/cancer-cell/...

This episode brought me back to my time working in a lab on the top floor of Stony Brook University’s Health Sciences Center. I have surprisingly fond memories for a place with no windows. It was like working in a weird Lego spaceship.