Kevin Murach

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blu...

“The Age-Dependent Resident Myonuclear Multi-Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice” advanced.onlinelibrary.wiley.com/doi/10.1002/...

A Different Type of ‘Muscle Memory’ Repeated exercise, or wasting, can change the way key genes work.

Nice feature in @theatlantic.com by @bonnietsui.bsky.social

Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses.

www.theatlantic.com/health/2026/...

Exercise to maintain and repair the ageing motoneurone-muscle axis Has received a Professorship grant of DKK 20,000,000 from the Lundbeck Foundation.

💪🧠Thrilled to be awarded this grant to study how exercise supports the motoneurone-muscle interaction during ageing - with awesome collaborators @kevinmurachphd.bsky.social and Kristine Freude

@ismcopenhagen.bsky.social

🙏@lundbeckfonden.bsky.social

lundbeckfonden.com/en/exercise-...

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle - Skeletal Muscle Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...

Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4

Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: kmurach@uark.edu and nelsonc@uark.edu #myoblue

First post on Blue Sky

New pre-print!

Does muscle remember disuse muscle wasting?

Our new study shows skeletal muscle retains a molecular memory of disuse!

Young muscle shows transcriptional resilience to repeated atrophy.

Aged muscle shows exaggerated susceptibility.

doi.org/10.1101/2025...

A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

PNAS Nexus – Issue 9 (2025) is now available. PNASnexus.org

Issue 9 (2025) of PNAS Nexus is now available! Discover how satellite cells orchestrate immune-fibrogenic circuits in aging muscle, machine learning for long-term scratching in mice, and more. Read here: https://ow.ly/bLeP50X5JVE

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle Abstract. Muscle stem cells, or satellite cells (SCs), decline in number throughout the lifespan and may become senescent in very old age. Whether and how

Final version in @pnasnexus.org “Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” academic.oup.com/pnasnexus/ar...

Dasgupta Lab at UNC Charlotte is hiring!
This space needs to be filled with laughter, breakthroughs, failures, high fives and everything in between! (Of course equipment!😛)
We will be studying cancer-induced muscle wasting!
DM or email for more info!
@cancercachexia.bsky.social
#myoblue

Prioritizing skeletal muscle health for successful aging Kevin A. Murach talks us through prioritizing skeletal muscle health for successful aging, beginning with a primer on skeletal muscle aging

Prioritizing skeletal muscle health for successful aging “The beneficial effects of exercise on skeletal muscle cannot be overstated, and the impact of healthy skeletal muscle on successful aging should not be underestimated.” www.openaccessgovernment.org/article/prio...

Muscle memory theory: A critical evaluation Click on the article title to read more.

“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...

Special Issue: Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity: The Journal of Physiology: Vol 603, No 13 <em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

Our Special Issue is live in J Physiology! w/ @mvfranchi.bsky.social & Prof. Paul Greenhaff “Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity”. So many great contributions! Add it to your reading list #myotwitter physoc.onlinelibrary.wiley.com/toc/14697793...

😛

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle Abstract. Muscle stem cells, or satellite cells, decline in number throughout the lifespan and may become senescent in very old age. Whether and how remain

“Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” @myoblue.bsky.social @pnasnexus.org academic.oup.com/pnasnexus/ad...

Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude | American Journal of Physiology-Cell Physiology | American Physiological Society

“Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude” journals.physiology.org/doi/abs/10.1...

microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism Metabolic flexibility refers to the ability of a tissue to adjust cellular fuel choice in response to conditional changes in metabolic demand and acti…

A tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...

Rejuvenation in planarians. Check out the details in this link: www.nature.com/nataging?gcl... @nataging.nature.com

Nice!!!

Our latest review is out now in @jphysiol.bsky.social

The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social

doi.org/10.1113/JP28...

Might have had to do with the age gap of the mice and/or the fiber type transition. We and others see growth in >4 month old C57s.

If you too are experiencing mental health issues due to the ongoing shitshow, please DM me or Signal me at ziadadina.19, I am trying to build a community to help each other.

Y'all, please repost and help me out, this is serious stuff

Myocellular adaptations to short-term weighted
wheel-running exercise are largely conserved during
C26-tumour induction in male and female mice #myoblue physoc.onlinelibrary.wiley.com/doi/epdf/10....

Final Version: “A history of omics discoveries reveals the correlates and mechanisms of
loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young
investigator award invited review” #myoblue journals.physiology.org/doi/epdf/10....

Aging, regeneration and whole-body rejuvenation in long-lived planarians - Nature Aging We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotyp...

Seems to go along with recent work from @longhuaguo.bsky.social www.nature.com/articles/s43...

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...

Chambers et al. “At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle” #myoblue onlinelibrary.wiley.com/doi/full/10....

Cool data here. We have some mouse data (regeneration, not amputation) that supports this! Stay tuned and great stuff @longhuaguo.bsky.social #myoblue @natureaging.bsky.social