Kevin Murach

Special Issue: Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity: The Journal of Physiology: Vol 603, No 13 <em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

Our Special Issue is live in J Physiology! w/ @mvfranchi.bsky.social & Prof. Paul Greenhaff “Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity”. So many great contributions! Add it to your reading list #myotwitter physoc.onlinelibrary.wiley.com/toc/14697793...

😛

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle Abstract. Muscle stem cells, or satellite cells, decline in number throughout the lifespan and may become senescent in very old age. Whether and how remain

“Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle” @myoblue.bsky.social @pnasnexus.org academic.oup.com/pnasnexus/ad...

Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude | American Journal of Physiology-Cell Physiology | American Physiological Society

“Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude” journals.physiology.org/doi/abs/10.1...

microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism Metabolic flexibility refers to the ability of a tissue to adjust cellular fuel choice in response to conditional changes in metabolic demand and acti…

A tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...

Rejuvenation in planarians. Check out the details in this link: www.nature.com/nataging?gcl... @nataging.nature.com

Nice!!!

Our latest review is out now in @jphysiol.bsky.social

The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social

doi.org/10.1113/JP28...

Might have had to do with the age gap of the mice and/or the fiber type transition. We and others see growth in >4 month old C57s.

If you too are experiencing mental health issues due to the ongoing shitshow, please DM me or Signal me at ziadadina.19, I am trying to build a community to help each other.

Y'all, please repost and help me out, this is serious stuff

Myocellular adaptations to short-term weighted
wheel-running exercise are largely conserved during
C26-tumour induction in male and female mice #myoblue physoc.onlinelibrary.wiley.com/doi/epdf/10....

Final Version: “A history of omics discoveries reveals the correlates and mechanisms of
loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young
investigator award invited review” #myoblue journals.physiology.org/doi/epdf/10....

Aging, regeneration and whole-body rejuvenation in long-lived planarians - Nature Aging We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotyp...

Seems to go along with recent work from @longhuaguo.bsky.social www.nature.com/articles/s43...

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...

Chambers et al. “At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle” #myoblue onlinelibrary.wiley.com/doi/full/10....

Cool data here. We have some mouse data (regeneration, not amputation) that supports this! Stay tuned and great stuff @longhuaguo.bsky.social #myoblue @natureaging.bsky.social

Thanks Dada! It was a nontrivial amount of work haha

Nice call. We can still fix it at proof stage!

A History of Omics Discoveries Reveals the Correlates and Mechanisms of Loading-Induced Hypertrophy in Adult Skeletal Muscle | American Journal of Physiology-Cell Physiology | American Physiological S... Since the early 2000s, omics approaches to study skeletal muscle hypertrophy consequent to loading (e.g. resistance exercise) have expanded dramatically. Beginning with genomics and transcriptomics, t...

This was a real labor of love: “A History of Omics Discoveries Reveals the Correlates and Mechanisms of Loading-Induced Hypertrophy in Adult Skeletal Muscle” w/Toby Chambers. #myoblue journals.physiology.org/doi/abs/10.1...

Biomarkers of aging: from molecules and surrogates to physiology and function | Physiological Reviews | American Physiological Society Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research of aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans have been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential anti-aging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

Our magnum opus on everything related to #aging is out as a preprint in Physiological Reviews @apspublications.bsky.social @apsphysiology.bsky.social #openaccess. Great collaboration with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch.

doi.org/10.1152/phys...

Some teasers:
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Really nice paper from @abigailmackey1.bsky.social looking at the interaction between myogenic cells and neurons! @lundbeckfonden.bsky.social

Thanks Liliana!

Thanks Julien!

Thanks Deena!

Thanks so much!

Agreed. I can do away with the facade of professionalism now and really lean into my vices ;)

Thank you Juha!

Thanks Jean! You going to Myology?

Thanks Russ! See you soon

You should see the top shelf 😉 thanks for the kind words.

Thanks so much Nir!