Giuditta De Lorenzo

Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

Taxonomic expansion and reorganization of Flaviviridae

www.nature.com/articles/s41...

📢 @who.int Global #YellowFever update, 2024 🦟

iris.who.int/server/api/c...

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...

New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬

Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social

www.embopress.org/doi/full/10....

Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity. Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...

Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...

Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/

Confirmed speakers:
- @davidlrobertson.bsky.social
- @grovearmada.bsky.social
- @fra-cutu.bsky.social
- @albecazzaniga.bsky.social
- Emanuele Andreano
- Alessandro Marcello

Only in person, free attendance 🙌 Limited spots remaining

AI in Virology: Leveraging AI to Advance Our Understanding of Viruses - Area Science Park Artificial intelligence is opening new perspectives in virus research, providing advanced tools to analyze viral evolution and to understand protein structure and dynamics on a large scale. To explore...

🧬 Excited to share our International Workshop: AI in Virology
📆 Sept 9, 2025 - Trieste, Italy
@AreaSciencePark
We’ll explore how #AI is transforming virology — from protein language models to vaccine design and biosecurity.
🔗 Program & details: www.areasciencepark.it/en/events/ai...

Proud moment: PhD student Beatrice Pani presented her very first poster at our Summer retreat! 😎 #AcademicLife #PhDJourney #MentorProud

Yeah, not a bad place for a conference...

#ECV2025

Always enjoyable and informative to listen to @peacockflu.bsky.social #microbio25

Once again, @wfurnon.bsky.social has very nicely delivered our study about the phenotypic evolution of SARS-CoV-2 spike. Well done mate! #microbio25

Exclusive: NIH to cut grants for COVID research, documents reveal Studies on climate change and South Africa are also on the latest list of grants to be terminated, according to updated documents obtained by Nature.

What a disgrace...
(just one of latest...)
www.nature.com/articles/d41...

The thing I need people to understand about the lab leak conspiracy is that, aside from the fact that there is no compelling evidence for a laboratory origin for SARS-CoV-2, the constant advancement of this idea is used for nefarious political purposes. In particular,…

Insects involved too 😁

So excited to hear the seminar of old friend and @icgeb.bsky.social alumni, Alessio Guglielmi, who started a career in forensic after his PhD.

It is finally out, our beautiful work 😍
You have never seen so many Spike at once 😎
But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social

Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic - Nature Microbiology Systematic comparison of SARS-CoV-2 spike proteins from pre- and post-Omicron variants in cell lines, primary respiratory epithelial cells and Syrian hamsters show distinct phenotypic trajectories in ...

For those interested in how SARS-CoV-2 is evolving, I found this paper to be interesting: Furnon et al, “Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic”, Nature Microbiology, www.nature.com/articles/s41...

Some of my notes about this paper: (1/13)

What will viruses do next? AI is helping scientists predict their evolution Forecasts of viral variation could improve vaccine and antiviral treatments ahead of time.

Great article on the growing use of #AI to study virus evolution, including insights from @cvrinfo.bsky.social @davidlrobertson.bsky.social.

www.nature.com/articles/d41...

Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.

With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

Postdoctoral Researcher in Structural Virology This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.

I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.

If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!

Application deadline: January 19th.

Please share with your networks 🙏

Job link: tiny.cc/7v33001

If like me, you love Dickens, the Brontë sisters & care about infectious diseases, this is for you! 👇

The role of vector population variation and climate in Zika virus transmission patterns in Africa: a modelling study Both population-level genomic variation in mosquitoes and climate contribute to the lack of ZIKV outbreaks in Africa. Given the importance of mosquito genetics in driving this pattern, local genomic surveillance of mosquito populations would help predict outbreaks in vulnerable communities. This will become increasingly important with population growth, urbanisation, and climate change.

Currently, Aedes mosquitoes that carry Zika Virus (ZIKV) in Africa (“subspecies”) do not prefer human hosts.

Climate change might change that.

“we predict that approximately three-quarters of the most populous African cities will be suitable for ZIKV outbreaks by the end of the century.”

🧪🛟🌎🦟💉🔬🩺

A Charles Rennie Mackintosh inspired panel, with an influenza virus in place of the rose, and text reading 'Influenza Update Meeting, University of Glasgow 2nd - 3rd December 2024'

Really looking forward to catching up with the influenza research community, from academia and industry across the UK and beyond, at next week's Influenza Update Meeting, which this year we're hosting here at the University of Glasgow. Can't wait!

POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has caused, unexpectedly, a large outbreak in dairy cattle in North America. It is critical to ascertain how this virus has specifically a...

🐄 NEW | Research from the CVR reveals how #H5N1 avian influenza has adapted to infect bovine cells, contributing to a major outbreak in dairy cattle in North America.

Multiple internal genomic segments of the virus drive its adaptation to bovine cells.

www.biorxiv.org/content/10.1...

Glasgow is fab, but also @cvrinfo.bsky.social !

I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............

Sooo helpful! May I ask to be included?

A real pleasure to participate in #prpconference2024. Well organized, great presentations and highly interactive. An excellent opportunity for networking. PRP: mission accomplished 👏🏼