Harry M. Williams

structure prediction is not science if not experimentally validated. period

FuGENE for me, seems to work quite well!

How do you combine soft-landing mass spectrometry with laser flash melting to prepare samples for single particle cryo-EM? Here's the answer!

❄️ NEW PRE-PRINT ❄️ Happy to see the last chunk of protein X-ray crystallography work I completed for my PhD appear on bioRxiv. The result of an excellent and long-standing collaboration between colleagues at Keele, Southampton, MRC Harwell, and University College Dublin. Enjoy!

A new paper from my new colleagues in Lausanne! Microsecond time-resolved cryo-EM rumbles closer day by day. Very cool work!

Glycerol is also a pet hate, luckily it's always in our cryoprotectant. 🫠

I think that if I never "fit" a water ever again, I would be fine with that. 😅

Things we love to see on a Monday morning: 4 new X-ray crystal structures deposited with PDB. Nice to see sub-2 Å maps again! Prepare the new paper klaxon.

Temporary!

Ciao Hamburg, you’ve been sweet. Next stop (eventually) Schweiz!

If another person says ‘we will use AI’ in reference to some difficult molecular problem I think I’m going to explode. I’m tired of people thinking AF and the subsequent revolution in molecular science is like a chatbot in any way. You need trained molecular scientists to make it work properly.
🧵

People who haven’t lived in Germany will never know the sense of satisfaction one has when you turn up to an administrative appointment with not just the correct documentation but everything in the correct format too.

Finally managed to swing by hamburgpotter after 4 years for some adorable bits of pottery.

The group is a method development one but we have around 10 projects running as use cases!

As Nelly Furtado says, all good things come to an end and after ~4 years in Hamburg, it's time to move on! In the next week or so, I'll being moving ~1000 km south'ish to Switzerland to work on microsecond time-resolved single particle cryo-EM. Exciting times ahead!

Certainly feels like people have lost the ability to disagree with each other gracefully! Truly sad state of affairs.

“Highly accurate” doing a lot of heavy lifting here…

The longer I’m around, the weirder I find groups where everyone is an expert in the same question, method, or specific field.

This is a good paper, single particle folks should read.

When doesn’t one’s brain need a hug?

Priority pathogen families research and development tool A reference tool to help guide England-based funders of research and development.

Good to see the UKs Health Security Agency new priority pathogen tool published, with many familiar names appearing in the list of priority viral families! www.gov.uk/government/p...

Dislike for no other reason than it’s change. 😄

Incredibly helpful FedEx, thank you so much. 👏

I tend to believe that getting involved is a good thing. So, if you are interested, please do!

Lots of great speakers, if you want to learn more about cryo-EM image processing, this is the place!

The data from the first Leibniz PostDoc survey is now available. Have at it, folks! The data from the second Leibniz PostDoc Survey will be released soon (trademark).

The sun has returned to Hamburg, and we love to see it.

We will host Gregor Kalinkat and Phoebe Griffith for the online workshop "Social Media for Scientists". They will explore how to optimise the visibility of our science and present the potential of various social networks! 🧑‍💻

🗓️ March 18th at 14:00 - 16:00 CET
📝 Register here: tinyurl.com/23pmvx3b

Structural basis of Nipah virus RNA synthesis - Nature Communications Sala et al. report the first structural snapshot of the Nipah virus RNA-dependent RNA polymerase in the actively elongating state, uncovering key mechanisms of RNA synthesis by non-segmented negative ...

The peer-revied version of our paper on the structure of the Nipah virus RNA polymerase in complex with RNA is out in @naturecomms.bsky.social. Congratulations to first-author @salafernanda.bsky.social and many thanks to the reviewers for their constructive comments!

www.nature.com/articles/s41...

Congrats Helen!