Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson's Disease https://www.biorxiv.org/content/10.64898/2026.02.09.704749v1
09.02.2026 22:33 — 👍 1 🔁 1 💬 0 📌 0
A near-complete map of human cytosolic degrons and their relevance for disease
We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence
Led by @vvouts.bsky.social in @rhp-lab.bsky.social
doi.org/10.1126/scia...
07.02.2026 07:41 — 👍 53 🔁 17 💬 0 📌 0
Led by @vvouts.bsky.social in @rhp-lab.bsky.social, we measured the degron potency of >200,000 30-residue tiles from >5,000 cytosolic human proteins and trained an ML model for degrons
📜 www.biorxiv.org/content/10.1...
🖥️ github.com/KULL-Centre/...
15.05.2025 12:44 — 👍 33 🔁 17 💬 0 📌 0
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
15.05.2025 11:56 — 👍 18 🔁 8 💬 0 📌 1
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
In our newest preprint we map degrons for >5,000 cytosolic proteins and we develop a degron predictor that can predict novel degron formation, a potential mechanism of pathogenicity. Many thanks to @rhp-lab.bsky.social, @lindorfflarsen.bsky.social and @dougfowler.bsky.social for their supervision.
15.05.2025 13:50 — 👍 4 🔁 3 💬 0 📌 0
Protein scientist in Copenhagen
Predoctoral Research Assistant at the Llorca lab @cniostopcancer.bsky.social working on mTORC1 signaling and cryo-EM ❄️🔬. Intrigued by the structural mechanisms of protein assemblies involved in endomembrane signaling and trafficking 🧪.
Assistant Professor at University of Copenhagen | Gene Regulation | Developmental Biology | Method Development | http://tgrlab.org
PhD Student in Integrative structural biology on RNA-binding proteins.
#crystallography #SAXS #NMR #RNA #biophysics #biochemistry #structuralbiology
Molecular biologist of plants, bugs, and microbes
A sound proteome for a sound body: targeting proteolysis for proteome remodeling
International, independent, interdisciplinary research institute. Integrates basic research and clinical expertise for innovative diagnostics and therapeutics.
🔗 http://www.cemm.oeaw.ac.at/
Supporting researchers and authors with professional editing 📝 grant writing 💰 manuscript proofreading👩💻 book editing📚 medical writing✍️ scientific consulting👩🏻🔬 author services 📖
👉Visit www.eloquenti.com
Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org
Explore groundbreaking news and research from PNAS, one of the world's most-cited scientific journals. Discover its sibling journal, @pnasnexus.org, both official research journals of the U.S. National Academy of Sciences. Visit www.pnas.org for more info.
A Nature journal dedicated to presenting the very best research across the disciplines of astronomy, astrophysics, cosmology and planetary science.📡
www.nature.com/natastron
Nature Catalysis publishes high quality work across all areas of catalysis, including both fundamental and applied studies.
https://www.nature.com/natcatal/
A chemistry journal for cutting-edge research and analysis from @natureportfolio.nature.com. Account run by @nchemgav.bsky.social and @joansp.bsky.social
https://www.nature.com/nchem/
A chemistry journal published by SpringerNature
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A new @natureportfolio.bsky.social journal publishing leading research, analysis, and commentary covering the breadth and depth of chemical engineering.
https://www.nature.com/natchemeng/
A monthly journal dedicated to publishing cutting-edge research on the nature, underlying causes or impacts of global climate change and its implications for the economy, policy and the world at large https://www.nature.com/nclimate
A @natureportfolio.nature.com journal on mathematical models and computational methods/tools that help advance science in multiple disciplines. https://www.nature.com/natcomputsci
Nature Ecology & Evolution publishes research and comment across the entire breadth of ecology and evolution, including both pure and applied topics. nature.com/natecolevol
A journal covering all areas of electronics research, incorporating the work of scientists, engineers and industry. https://www.nature.com/natelectron/
Nature Energy is a peer-reviewed research journal that publishes the latest advances in the energy field, from the generation, storage, and distribution of energy to the societal impact of energy technologies and policies.
www.nature.com/nenergy
