Robert Krautz

I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!

link.springer.com/collections/...

Jeg står her omkring i morgen fra ca. kl 10 og frem til 11:30 eller der omkring. Så går turen videre til Panum. Håber vi ses!

Tusind tak Stinus! Jeg sender informationen ud til så mange som mulig. Jeg undervise dog mellem 9:15 og 12:00. 🫣😤 Først og fremmest, helt og lykke på de sidste meter!

Tak Stinus. Det ville være fremragende. 100 millioner spørgsmål 😉 strømmer over campus lige nu, som alle prøver at finde svar på. Jeg er sikker på, at et besøg på din gamle hjemmebase ville hjælpe med at finde nogle af disse. 🙏 Ses forhåbentlig mandag.

Tak for svaret. Definitivt klokken 12. Der er et krydsningspunkt i midten af Nørre Campus (55.7004652, 12.5599248), hvor alle skal forbi mellem bygningerne. Tak! 🙏

Kommer Du / I også forbi KU, måske endu bedrer Nørre Campus? Jeg tror på Science er der lige i øjeblikket mange med behov for at snakke.

Diagrams of fruit fly larvae (left) and adult (right) annotated with genes expressed in different tissues, including male- or female-biased gene expressions.

A diagram providing an overview of the regulation of antimicrobial peptide and other host effector peptides by Toll and Imd signalling, alongside diagrams showing the diversity of the peptides.

A summary table illustrating sequence features common to antimicrobial peptides, and a summary table of gene families.

A diagram giving a model for the mechanisms of antimicrobial peptide and host defence peptide actions in killing microbial cells, including precise mechanisms, broader host-pathogen relationships, and non-microbicidal roles of these peptides in protecting the host.

Bizarre that our 2020 #Drosophila #AMP review already feels out of date.

Thanks to #AnnualReviews to cover the many updates in the field and present a much more complete picture of the diversity, mechanisms, topics, of fly immunity re: host defence peptides.

www.annualreviews.org/content/jour...

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale

See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs

📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...

Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41...

Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon

Brief thread 👇

Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

HDAC3 prevents enhancer hyperactivation to enable developmental transitions Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Guess, I'll have a coffee then.

Beautiful pictures indeed. What is your weapon of choice: Illustrator or Inkscape?

Craft House Prague?

Emerging principles and models of human primordial germ cell development Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

The shocking hit film about overworked nurses that’s causing alarm across Europe A Swiss film about a nurse pushed to her limits one night is being praised for the picture it paints of treacherously underfunded healthcare. The director talks about the ‘heart-pounding’ story that i...

“Nurses should be at the very top of our social hierarchy but we live in a world where it’s just the opposite,”

www.theguardian.com/film/2025/ju...

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health.

Apply here:
👉 RA: www.jobs.cam.ac.uk/job/51988/
👉 Postdoc: www.jobs.cam.ac.uk/job/51984/

Please share 🔬👩‍🔬

📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏

Tomorrow at 19:30 a huge demonstration in Tel Aviv - The Israeli Academia demands to end the war NOW. These horrors are unbearable and must stop.

“Simple” experiment, but crucial point: we won’t identify all gene regulatory mechanisms underlying disease by simply looking at healthy tissues / cell lines under norm conditions.

Is this consciously ambiguous? After all he is the Lord of the Dance. 😉

I second this. Such additional data is great for documentation purposes, but in order for someone (us) to make a systematic change to the publishing model, such stats need to incite a whole field to want to change. As long as authors (us) accept 3 y & ~10 m publishing time, no change will occur.

I’m the dNTPs and my wife the polymerase. After two cycles, no one cares about where everything started or ends, only that you work together to string a sequence of meaning together.

So you basically print out the info from the background signal in combination with your actual peak score, so that one could use the former to e.g., color-code the latter based on CNVs?

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function.

Deadline July 15th.

www.mdc-berlin.de/career/jobs/...

GitHub - vierstralab/hotspot3: A chromatin accessibility peak caller with an adaptive background model A chromatin accessibility peak caller with an adaptive background model - vierstralab/hotspot3

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback!

github.com/vierstralab/...

Naive question: if you can control for CNVs & aneuploidies, can you so also highlight / annotate peaks identified to be detected in such genome regions. That might be really exciting from a biological point, to contrast peaks inside vs outside?

Couldn’t agree more, Aarhus is amazing. The university is also visually stunning, great architecture.

Aarhus centrum, Østergade, I would say. Close to the main shopping street, Søndergade.

Not stalking you, just know my Berlin. 😉 Half an A, a “l” and a “b” are enough.