Robert Krautz

Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

HDAC3 prevents enhancer hyperactivation to enable developmental transitions Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Guess, I'll have a coffee then.

Beautiful pictures indeed. What is your weapon of choice: Illustrator or Inkscape?

Craft House Prague?

Emerging principles and models of human primordial germ cell development Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

The shocking hit film about overworked nurses that’s causing alarm across Europe A Swiss film about a nurse pushed to her limits one night is being praised for the picture it paints of treacherously underfunded healthcare. The director talks about the ‘heart-pounding’ story that i...

“Nurses should be at the very top of our social hierarchy but we live in a world where it’s just the opposite,”

www.theguardian.com/film/2025/ju...

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health.

Apply here:
👉 RA: www.jobs.cam.ac.uk/job/51988/
👉 Postdoc: www.jobs.cam.ac.uk/job/51984/

Please share 🔬👩‍🔬

📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏

Tomorrow at 19:30 a huge demonstration in Tel Aviv - The Israeli Academia demands to end the war NOW. These horrors are unbearable and must stop.

“Simple” experiment, but crucial point: we won’t identify all gene regulatory mechanisms underlying disease by simply looking at healthy tissues / cell lines under norm conditions.

Is this consciously ambiguous? After all he is the Lord of the Dance. 😉

I second this. Such additional data is great for documentation purposes, but in order for someone (us) to make a systematic change to the publishing model, such stats need to incite a whole field to want to change. As long as authors (us) accept 3 y & ~10 m publishing time, no change will occur.

I’m the dNTPs and my wife the polymerase. After two cycles, no one cares about where everything started or ends, only that you work together to string a sequence of meaning together.

So you basically print out the info from the background signal in combination with your actual peak score, so that one could use the former to e.g., color-code the latter based on CNVs?

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function.

Deadline July 15th.

www.mdc-berlin.de/career/jobs/...

GitHub - vierstralab/hotspot3: A chromatin accessibility peak caller with an adaptive background model A chromatin accessibility peak caller with an adaptive background model - vierstralab/hotspot3

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback!

github.com/vierstralab/...

Naive question: if you can control for CNVs & aneuploidies, can you so also highlight / annotate peaks identified to be detected in such genome regions. That might be really exciting from a biological point, to contrast peaks inside vs outside?

Couldn’t agree more, Aarhus is amazing. The university is also visually stunning, great architecture.

Aarhus centrum, Østergade, I would say. Close to the main shopping street, Søndergade.

Not stalking you, just know my Berlin. 😉 Half an A, a “l” and a “b” are enough.

Albrechtstrasse, Berlin. Close to the Charité?

Several conferences I attended used bullet / lightning talks introducing (again selected only) posters in 1-2 min. Perfect for getting the feeling of having presented, standing in front of an audience & acknowledgement on the presenters side & a decent overview in a calm environment for audiences.

Range extender mediates long-distance enhancer activity - Nature The REX element is associated with long-range enhancer–promoter interactions.

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Is Leptomycin volatile / unstable that warrants such packaging? Should Sigma not also embark on more green packaging solutions?

Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers Abstract. Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effec

(1/n) Excited to present the latest work from the de Wit lab, where we identify and characterise loop extrusion-mediated fountains in mammalian genomes using acute depletion of 3D genome regulators: doi.org/10.1093/nar/.... A Bluetorial🧵:

Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation Transcription factor (TF) cooperativity plays a critical role in gene regulation. However, the underlying genomic rules remain unclear, calling for scalable methods to characterize the TF binding site...

Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations!

Preprint: www.biorxiv.org/content/10.1...
Github: github.com/anderssonlab...

Latest from the lab! Led by @xuening-he.bsky.social, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for transcription factor cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!

Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d) Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.

Postdoc🚨!

Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro