Congrats to Jinsuke Nishino, Ashwin Kistagari and Wenhuo Hu, as well as @schunglab.bsky.social members Rusty Vittrup, Nesli Kalkan, Abhi Cherukuri and collaborators Robert Collins, Yazan Madanat, Brian Shaffer, Amer Zeidan, Lohith Gowda, Rahul Shah, Aram Bidikian, and Adetola Kassim.

Our data suggest a simple peri-transplant change to β1-selective inhibitors (Carvedilol->Metoprolol) could mitigate this effect. Our findings were consistent at UTSW and @vumc.bsky.social, but validation at other centers promises to identify patients for whom this is most relevant.

Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants Abstract. Peripheral nerves promote mouse bone marrow regeneration by activating b2 and b3 adrenergic receptor signaling, raising the possibility that non-selective b blockers could inhibit engraftmen...

Honored to contribute to this study by @seanjmorrison.bsky.social and team. In patients undergoing allogeneic transplantation and receiving post-transplant cytoxan, the use of non-selective β-blockers may significantly delay engraftment and worsen survival. aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery: Non-selective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans After Hematopoietic Cell Transplants - by Jinsuke Nishino, Wenhuo Hu, Ashwin Kishtagari, Stephen Chung, Sean Morrison and colleagues doi.org/10.1158/2159...

CRI scientists link hematopoietic cell transplant deaths to beta-blocker use - Children's Medical Center Research Institute (CRI) | Dallas Texas Morrison Lab research shows nerve signaling needed for bone marrow regeneration may be impaired by medication DALLAS – Dec. 30, 2024 – Patients can die if they take certain previously prescribed beta-...

ONLINE NOW in Cancer Discovery: CRI scientists link hematopoietic cell transplant deaths to beta-blocker use. Research from @seanjmorrison.bsky.social & colleagues shows nerve signaling needed for regeneration may be impaired by medication. #relentlessdiscovery 🧪 cri.utsw.edu/cri-scientis...

Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants Abstract. Peripheral nerves promote mouse bone marrow regeneration by activating b2 and b3 adrenergic receptor signaling, raising the possibility that non-selective b blockers could inhibit engraftmen...

Congrats to Jinsuke Nishino, @StephenChung16, @AshKishtagari, @huwenhuo for paper out in Cancer Discovery today: use of non-selective b blockers impairs engraftment after allogeneic hematopoietic cell transplants involving post-transplant chemo for GVHD prophylaxis

aacrjournals.org/cancerdiscov...

For answers to these questions and more, please come to Ben Kroger‘s presentation at 5:00 PM in Ballroom 20CD (San Diego Convention Center) – Abstract #347

#ASH24 #HemeSky #Hematology #ASHTrainee

Why do patients with germline mutations in DDX41 who develop MDS or AML have such indolent disease? How do somatic DDX41 mutations cause disease when present at very low levels? What are the role of other cooperating mutations? How does transplant work in these patients?