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Henry De Belly

@henrydebelly.bsky.social

Postdoc in Orion Weiner's lab at UCSF. I work at the interface of Cell Biology and Biophysics. I am into: #Actin, #Membrane, #CellMigration, #Polarity, #Cats, #Mechanobiology #Cheese #CellBiology

966 Followers  |  731 Following  |  27 Posts  |  Joined: 08.10.2023  |  1.7463

Latest posts by henrydebelly.bsky.social on Bluesky

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S1P induces bleb-based T cell motility via S1PR1-dependent activation of RhoA and WNK1 In vivo, the chemokine CCL19 and its receptor CCR7 control T cell retention in lymph nodes, while the lipid chemoattractant spingosine-1-phosphate (S1P) drives T cell egress from lymphoid organs. CCL1...

Privileged to have been involved in this great story led by Franklin from the Burkhardt's lab, showing the role of S1P in controlling naive T cell motility! www.biorxiv.org/content/10.1...

22.10.2025 17:20 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Looking for curious and creative scientists (technicians, postdocs…) to join the team. Come do some cool imaging with me, such as this migrating neutrophil with front πŸ”΄ and back πŸ”΅ polarity biosensors!

More infos about the lab here: cri.utsw.edu/faculty/henr...

16.10.2025 22:00 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!

We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

16.10.2025 22:00 β€” πŸ‘ 60    πŸ” 15    πŸ’¬ 8    πŸ“Œ 2
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@henrydebelly.bsky.social @oweinerlab.bsky.social elegantly showed how migrating cells exhibit a long-range mutual activation and partitioning of GTPases at both the front and back of the cell, functioning as an integrated mechano-chemical system. He’s also recruiting for his new lab!πŸ§‘β€πŸ”¬#MBIMPG2025

10.09.2025 09:13 β€” πŸ‘ 15    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...

08.07.2025 12:46 β€” πŸ‘ 60    πŸ” 19    πŸ’¬ 2    πŸ“Œ 0

Woop woop!!! πŸ₯³

05.06.2025 23:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Circular lab logo consisting of a ball of cells labeled with cyan nuclei and red cilia, surrounded by a white circle and the text Choksi Lab and UCSF. The 'o' in Choksi is a schematic of a multiciliated cell.

Circular lab logo consisting of a ball of cells labeled with cyan nuclei and red cilia, surrounded by a white circle and the text Choksi Lab and UCSF. The 'o' in Choksi is a schematic of a multiciliated cell.

I'm thrilled to announce that my lab is opening this August in the Department of Cell & Tissue Biology @ UCSF!

We will study airway stem cells and explore how they generate multiciliated cells (my favorite!) to keep pathogens and debris out of the lung. Check out choksilab.org for more!

05.06.2025 14:29 β€” πŸ‘ 55    πŸ” 5    πŸ’¬ 11    πŸ“Œ 3
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CTB welcomes new Assistant Professor Semil Choksi @semilc.bsky.social to the department! The Choksi Lab will study how airway stem cells generate multiciliated cells - and how this process goes wrong in respiratory disease. His lab is opening this August. Visit choksilab.org to learn more!

05.06.2025 23:07 β€” πŸ‘ 18    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
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#Science Bluesky, do your thing:
We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas.
Can you indicate some names to me?

30.05.2025 20:23 β€” πŸ‘ 36    πŸ” 26    πŸ’¬ 4    πŸ“Œ 2

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

23.05.2025 17:56 β€” πŸ‘ 2265    πŸ” 1324    πŸ’¬ 34    πŸ“Œ 31

I am a proud HHMI Gilliam Fellow alumn. The HHMI funded me at a critical time in my career - a real inflection point that made me realize that I had a place and future in science. I always looked to the HHMI as a safety net to those historically excluded by academia, 1/4

16.05.2025 16:55 β€” πŸ‘ 63    πŸ” 26    πŸ’¬ 1    πŸ“Œ 0
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Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...

πŸš¨πŸ“£ New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
πŸ“„ www.biorxiv.org/content/10.1...
#devbio #mechanics

12.05.2025 14:01 β€” πŸ‘ 84    πŸ” 35    πŸ’¬ 1    πŸ“Œ 3
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Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: β€œLeucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

27.03.2025 19:45 β€” πŸ‘ 84    πŸ” 30    πŸ’¬ 7    πŸ“Œ 4
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In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

21.03.2025 16:18 β€” πŸ‘ 59    πŸ” 33    πŸ’¬ 3    πŸ“Œ 5

This is a huge loss. Michael's work has been extremely influential and inspirational. He was one of my favorite scientist of all time...

21.03.2025 20:20 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

10.03.2025 16:32 β€” πŸ‘ 578    πŸ” 85    πŸ’¬ 16    πŸ“Œ 16
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CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...

10.03.2025 03:36 β€” πŸ‘ 96    πŸ” 31    πŸ’¬ 12    πŸ“Œ 0
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Huge crowds in SF today for #standupforscience. inspiring stories, not only from scientists like @carolynbertozzi.bskyverified.social, but also people who have lived through life-saving/changing experiences as a direct consequence of federally-funded scientific research πŸ’ͺ🏽

08.03.2025 03:43 β€” πŸ‘ 180    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0
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French University to Fund American Scientists Who Fear Trump Censorship The program, called β€˜safe place for science,’ offers American scientists funding to continue their research in France.

Added bonus: You would get to live in the South of France!πŸ‡«πŸ‡· πŸ·β˜€οΈ

πŸ§ͺ

www.404media.co/french-unive...

05.03.2025 18:20 β€” πŸ‘ 47    πŸ” 24    πŸ’¬ 3    πŸ“Œ 2
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Unique opportunity to join the CytoMorpho Lab (in Paris ❀️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost πŸ™ thanks !

05.03.2025 17:20 β€” πŸ‘ 62    πŸ” 77    πŸ’¬ 0    πŸ“Œ 1
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Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below πŸ‘‡πŸ‘‡
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

03.01.2025 15:33 β€” πŸ‘ 68    πŸ” 89    πŸ’¬ 0    πŸ“Œ 3

The lanyards at ASCB this year are comically loud. It's like everyone is wearing little bells around their necks πŸ””.

14.12.2024 20:05 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Hi! Thought I'd mosey on down to bsky as well with the rest of the science peeps! I love combining old-school biochemistry with all the 'omics' to discover new things about organelle function and cellular metabolism in health and disease.

09.12.2024 23:39 β€” πŸ‘ 13    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Excited for some cool science at #CellBio2024 this year! Come by my poster (Sun. Dec 15, 1.30-3pm Board B136) and stay for my talk (Sun. Dec 15, 4 pm Rm 33B) where I'll tell you about our work on a lysosomal mechanism for membrane protein degradation!

09.12.2024 23:41 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social πŸ‘‡https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

03.12.2024 09:18 β€” πŸ‘ 189    πŸ” 47    πŸ’¬ 5    πŸ“Œ 7

Congratulations on the beautiful story!!
Motility 🀝 Cytokinesis

21.11.2024 10:14 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social β€œA tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice”
authors.elsevier.com/a/1k7fg3QW8S...

20.11.2024 19:44 β€” πŸ‘ 89    πŸ” 25    πŸ’¬ 7    πŸ“Œ 5

Damn that sucks, I can't imagine the stress... I also don't get it, seems that you can only benefit from doing back to back papers...

21.11.2024 10:07 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

But you very nicely approached me to tell me you were in contact with Matthieu about co-submitting! It blew my young mind that this was even an option.

Honestly witnessing the whole process really opened my mind about the power and awesomeness of co-submission.

Collaboration>>Competition

20.11.2024 14:26 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

I remember presenting my (small) part of this work at a symposium a while back (I was a master student at the time). You had presented a bit before me and I was very nervous presenting because I was wondering if you were competing with Matthieu...

20.11.2024 14:26 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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