Inserm U1034 - Biology of Cardiovascular Diseases

Thesis defense season is open ! 🎓
Congratulations to Marin Lahouati, who brillantly defended his PhD last week ! 🎉 We wish you all the best for your next career chapter !

24.09.2025 07:37 — 👍 2    🔁 0    💬 0    📌 0

Last week, #InsermU1034 presented their work at the #PrintempsdelaCardiologie at St Malo ! A special congratulation to Célia Bourguignon, PhD student, who won the poster price ! Many thanks to the organizers and speakers ! #GRRC #SFCardio

28.05.2025 07:47 — 👍 3    🔁 0    💬 0    📌 0

Our review on the treatment of thrombotic complications in patients with myeloproliferative neoplasms has just been published in the latest issue of Blood, in a “how I treat” series on MPN.

23.04.2025 16:31 — 👍 6    🔁 5    💬 0    📌 0

Last week, @candicechaps.bsky.social and @margauxlaisne.bsky.social presented their work in #EMBOastrocytes2025 in Venice. Many thanks to @embo.org for the great organization and speakers for all these inspiring talks !

25.04.2025 12:47 — 👍 4    🔁 1    💬 0    📌 1

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice - Cardiovascular Diabetology Background Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of ...

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[Publication] Dr. Foussard and Dr Renault latest publication in @biomedcentral.bsky.social shows that ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice.
cardiab.biomedcentral.com/articles/10....

25.04.2025 12:09 — 👍 3    🔁 1    💬 0    📌 0

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis - Journal of Neuroinflammation Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that astrocytic Delta-like 4 (DL...

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[Publication] Happy to share @candicechaps.bsky.social and Dr Mora latest publication in @biomedcentral.bsky.social. They demonstrate that Dll4-Notch1 pathway controls astrogliosis in neuroinflammatory context such as MS. jneuroinflammation.biomedcentral.com/articles/10....

25.04.2025 12:04 — 👍 3    🔁 2    💬 0    📌 0

Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease - Journal of Translational Medicine Background Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpi...

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[Publication] Explore our latest publication on DNases and NETs in COVID-19. Investigating DNase activity in thrombo-inflammation may identify clinical scenarios for DNase administration, potentially averting clinical deterioration !
translational-medicine.biomedcentral.com/articles/10....

25.04.2025 12:02 — 👍 2    🔁 0    💬 0    📌 0

American Heart Association Journals

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[Publication] Dr @pauline-bougaran.bsky.social, Dr Bats and Pr Dufourcq published they last work on «ROR2/PCP a New Pathway Controlling Endothelial Cell Polarity Under Flow Conditions» in @ahajournals.bsky.social.
www.ahajournals.org/doi/10.1161/...

25.04.2025 12:00 — 👍 1    🔁 0    💬 0    📌 0

Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Heart failure with preserved ejection fraction is proposed to be caused by endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular and cellular mechanisms under...

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[Publication] Happy to share Dr Renault, Dr
Rouault and Dr @sarahguimbal.bsky.social publication in which they demonstrated that small vessels thrombosis may participate in the pathophysiology of #HFpEF in @ahajournals.bsky.social 🫀
www.ahajournals.org/doi/10.1161/...

25.04.2025 11:55 — 👍 3    🔁 2    💬 0    📌 0

Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms Neutrophils participate in the pathogenesis of thrombosis through the formation of neutrophil extracellular traps (NETs). Thrombosis is the main cause of morbidity and mortality in patients with myelo...

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[Publication] Thrilled to share that our article about the role of NETs in myeloproliferative neoplasms-associated thrombosis has been published in @jthjournal.bsky.social !
www.jthjournal.org/article/S153...

25.04.2025 11:52 — 👍 3    🔁 1    💬 0    📌 0

Partial Mural Cell Ablation Disrupts Coronary Vasculature Integrity and Induces Systolic Dysfunction | Journal of the American Heart Association

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[Publication] Happy to share Dr Renault and
Dr Cornuault's new publication in which they demonstrated that #cardiacpericytes are essential for maintaining #cardiacfunction, directly modulating cardiomyocyte properties and preventing cardiac inflammation. www.ahajournals.org/doi/full/10....

25.04.2025 11:49 — 👍 1    🔁 0    💬 0    📌 0