Yassi Aghazadeh

Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...

Very excited about our project aiming at advancing cell therapies for type 1 diabetes. and very thankful for receiving funding from @stemcellnetwork.ca

DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian c...

Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪
#PancSky #StemCells

www.biorxiv.org/content/10.1...

Poster titled Stem cell-based models of early human development

Stem cell-based models of early human development

Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social:
journals.biologists.com/dev/article/...

Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening Type 1 diabetes is recognized as a chronic disease with a presymptomatic phase that does not require insulin therapy and a clinical phase where insulin treatment becomes necessary. The presymptomati...

Bonifacio and Ziegler summarize current evidence and guidance while emphasizing the need for continued research alongside broader screening application in #type1diabetes. 🧪
#PancSky

dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, alleviates ER stress and reduces beta-cell immunogenicity

www.cell.com/cell/fulltex...

Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes - Diabetologia Aims/hypothesis Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by t...

Enterovirus infections may occur throughout the natural history of type 1 #diabetes and may be associated to islet cell HLA-I hyperexpression. @teresarc.bsky.social @sarahibex.bsky.social #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓

Deleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation level...

I've been really hoping someone would do a study like this!

www.mcponline.org/article/S153...

Nice discussion on the usefulness of genetic and autoantibody screening in children for T1D

Happy Persian new year, Norouz, and the beginning of spring! 🌸🪻☀️

Me as well!

a man holding two cell phones with the words kind of a big deal ALT: a man holding two cell phones with the words kind of a big deal

Today, rising stars @drprentice.bsky.social and @yassiag.bsky.social swing through the 🇨🇦 National #Islet and #Diabetes Course to discuss the latest on vascularizing stem cell-derived islet cells, adipose-islet communication, beta cell proliferation, and more @cirtn.bsky.social

Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social

More cause to celebrate in this anti science climate! Happy international day of women and gender minorities in science 🧬

Read the latest Special Topic on Endothelial Cell and Pericyte Homeostasis and Pathogenesis in JHC: "Role of the Pancreatic Islet Microvasculature in Health and Disease."

Click to read for FREE: bit.ly/4fihNMw

#capillary #diabetes #endothelialcell

Still time to apply!

Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

#RECRUITMENT | Shape Your Future in Biomedical Research At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research. The recruitment period runs from December 15, 2024, to January 31, 2025. If you are selected by our researchers, you will be invited, at the IRCM's expense, to participate in a short stay at our facilities in May 2025. #DrivenByLife

#RECRUITMENT | Shape Your Future in Biomedical Research
At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research.
The recruitment period runs from December 15, 2024, to January 31, 2025. www.ircm.qc.ca/en/studies
#DrivenByLife

Liver and pancreas in metabolic disease: from pathways to therapies The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉

meetings.embo.org/event/25-liv...

So sorry to hear this 💔💔💔 my heart is with you and him :(

Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes In this article, Nunes Vasconcelos and colleagues show that co-delivery of adipose-derived microvessels and hiPSC-cardiomyocytes improves cardiomyocyte survival, graft size, and cardiac function in a ...

Amidst the craziness in the world right now I feel there is even more reason to celebrate:
Xuetao's paper is now online! Check it out : www.cell.com/stem-cell-re...
1/3

Congratulations Xuetao & Sara! Nice work!

Congratulations to all!

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

This CityNews report highlights the expertise of Dr. Jane Yardley of the IRCM whose research focuses on physical activity in postmenopausal women living with type 1 diabetes.

bit.ly/4fHOvXL

Celebrating the end of a fun, collaborative & productive year! Wishing everyone a happy holiday season ⛄️

Important discussion in @devbiol.bsky.social by Scott Gilbert.

As scientists, and as developmental biologists, we really need to share the facts we know with the public. #DevBio

Provincial Grand Finale of the Science POP Competition: Science Comes Out on Top

#SciencePOP | Discover the 2024 winners in pictures
Before a delighted audience, finalists of 12 institutions from all across Quebec gathered and competed in three high-level challenges.
www.ircm.qc.ca/en/news-deta...

Scientist I - Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12831982 Princess Margaret seeks early-career faculty scientists to establish research programs in Cancer Biology - broadly defined.

We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word!

www.nature.com/naturecareer...