DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)

Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)

www.biorxiv.org/content/10.1...

DNA methylation clocks were always known to be confound by genetics (the Illumina assay is a repurposed SNP chip after all)

Here established (white ppl) DNAm "aging" clocks fall apart in other ethnicities (& as usual don't explain much clinical variation in anyone)

www.biorxiv.org/content/10.1...

Consecutive skeletal muscle PGC-1α overexpression: A double-edged sword for mitochondrial health in the aging brain Mitochondrial dysfunction is a critical contributor to age-related functional declines in skeletal muscle and brain. Peroxisome proliferator-activated…

Seems somebody just trashed the Irisin idea" even for mice. 😜

www.sciencedirect.com/science/arti...

3/3 @cbmr.science #StenoDiabetes #Novo Nordisk

Aside from this, the trial design is flawed. It's well established the IS response to a training program (single arm) are >> heterogeneous, i.e. mean differences between small subgroups, on different treatments, can't be attributed to protocol alone 🤦‍♂️

@cbmr.science #StenoDiabetes #Novo Nordisk
2/3 How do u publish a study like this & not cite the largest HIT study in over-weight, sedentary adults (doi.org/10.3389/fend...) with varying degrees of IR, where they identified a molecular signature related (doi.org/10.1093/nar/...) to reversal of IR?

1/3 High-intensity interval training improves insulin sensitivity
in individuals with prediabetes

academic.oup.com/ejendo/artic...
Danish researchers, Knop, Vilsboll et al once again proving they have either no access to Pubmed, or they are happy to dishonestly reflect the state of the literature

Differences in fibre recruitment render the current interpretation of this small study mute.

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...

More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...

No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.

> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story

The details matter; while I suspected this 7% was best case scenario - it seems informative censoring could have influenced the results to the point that there was no real benefit of exercise (excess censoring in the exercise arm; exercise killed off the weak?)

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

7% absolute improvement in survival

www.nejm.org/doi/full/10....

😂😂😂😂😂😂😂😂😂

Exercise scientists eh. Even here, when there's a clearly a very positive story they have to bs about 'better than drugs' when it's not a primary prevention cancer trial. Expected that cardio metabolic risk factors contribute to further risk. As good as it gets for an exercise study

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from over 1,000 participants to identify distinctive molecular signatures in human skeletal muscle adaptation to various ...

Old presented as new @cellreports.bsky.social‬

Flattering sports scientists finally listening re sample-size

Led by a king of citation fraud ‪@nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors

www.cell.com/cell-reports...

90% of science should be making sure the assay is valid and reproducible

A collage of several figures from the retracted paper, of invasion assays and wound healing assays; showing different panels with cells growing on a surface. I have added loads of colored boxes to show duplicated areas.

A retraction by Oncotarget, but the journal is taking all the credit for my 2020 findings!

"Oncotarget’s Image Forensics analysis identified multiple instances of image manipulations".

What a crappy move from Oncotarget.

HT: @thatsregrettab1.bsky.social
pubpeer.com/publications...

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from over 1,000 participants to identify distinctive molecular signatures in human skeletal muscle adaptation to various ...

Old presented as new @cellreports.bsky.social‬

Flattering sports scientists finally listening re sample-size

Led by a king of citation fraud ‪@nireynon.bsky.social ignores >> studies eg. RUNX1 identified by Keller et al. 2011. So much wrong with the work & authors

www.cell.com/cell-reports...

Screenshot of a tweet by ScienceGuardians - you can read the whole text here: https://archive.ph/wip/5Pswm "🚨 Attention, members of the academic community: If you feel you are being unjustly targeted by malicious campaigns on anonymous, unaccountable platforms like PubPeer… If you’ve experienced unfair or disproportionate treatment by publishers who generally evade responsibility—placing the burden, blame, and consequences entirely on authors, the very people sustaining academia and publishing, yet receiving no financial benefit… 🔱 ScienceGuardians™ is here to give you a voice. We stand with every scholar facing intimidation, unfair targeting, or institutional neglect. We investigate each case thoroughly and impartially, ensuring fairness, accountability, and integrity are upheld. 👉 Contact us confidentially: 📧 support@scienceguardians.com 📧 scienceguardians@gmail.com ✅ Register at https://scienceguardians.com to become a Science Guardian yourself. Contribute to a respectful, evidence-based, and accountable post-publication peer review process—where members of the academic community empower each other without fear of harassment or orchestrated campaigns. 🔗 Follow us on X for updates, investigations, and resources: @SciGuardians 📢 Please share this message widely to ensure it reaches every member of the academic community, in every university, in every corner of the world. 🔱 Together, we safeguard science. #AcademicIntegrity #ResearchEthics #PublishingEthics #AcademicFreedom #PostPublicationPeerReview #Empowerment #ScienceGuardians" https://x.com/SciGuardians/status/1918366296212947237

How is ScienceGuardians different from PubPeer?
Several PubPeer users have been able to register on ScienceGuardians and post the exact same type of concerns.
Why is PubPeer "unaccountable" and "malicious" and SG "respectful" and "accountable"?
I see absolutely no difference.

The playbook for a good paper on Aging or Ageing

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

The do’s and don’ts of scientific image editing

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

@sarareardon.bsky.social reports

www.nature.com/articles/d41...

The results, based on 1 mouse strain are interesting but life-long reduction in NAD+ doesn't in itself challenge that loss of NAD+ in humans doesn't a) have consequences or b) respond to supplemental intervention.

As usual, headline below is more marketing than clinical science.

Same issue with every positive TG/KO mouse story - one strain, life long accommodation to the defect.
On different genetics, different diet or different housing temperature who knows 🤷‍♂️
Broader question is how often are KO/TG mice on one background informative ?

And of course #justinmice

lol. Sledgehammer (genetics) to crack the nut (diet diary data).

Shame the cases & controls aren't matched for key physiology VO2max or Physicla activity (& why no sample size in the demographics table?).

Might be T2DM, might not 🤷‍♂️. Small studies on T2DM have proven to being reliable past two decades

The idea it's a therapeutic target is however v fanciful.

Another T2DM study that fails to control for known confounding factors while implying good matching? Feels like Mootha 2003 all over again.

No matching for VO2max or Physical activity (you can't even be bothered to list the sample size in the demographics table)

Stories for stories sake.

Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis Nature Communications - The transcription factor Myc stimulates growth in many cells. This study shows that Myc expression is essential in muscle stem cells to support muscle growth, but is neither...

Taking the Mick...

2025: Muscle fiber Myc is dispensable for muscle growth
rdcu.be/egQbm

2024: MYC is sufficient for muscle growth
www.embopress.org/doi/full/10....

2013: MYC was negatively linked to RT growth
doi.org/10.1371/jour...

Light touch review assured for all molecular & genomic data.

Absolute substrate oxidation rates are lower in older adults with amnestic mild cognitive impairment Previous studies in individuals with mild cognitive impairment suggest that they may have altered systemic metabolic function at rest; however, metabolic function during aerobic exercise is not fully...

Claimed mitochondrial phenotype in mild cognitive impairment
doi.org/10.14814/phy...
Yet lack of physical activity measures renders study invalid.

Seems physiology journals can't do physiology - more interested in making money your social gatherings than good science?
@physoc.bsky.social

Human Skeletal Muscle Disuse Atrophy has Profound and Negative Effects on the Muscle Metabolome and Lipidome | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Soci... We investigated how short-term muscle disuse altered the skeletal muscle metabolome, lipidome and transcriptome in middle-aged adults. We report that the energy metabolism pathways: Nicotinate and nic...

Human Skeletal Muscle Disuse Atrophy has Profound and Negative Effects on the Muscle Metabolome and Lipidome
journals.physiology.org/doi/abs/10.1...

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...

More deceptive data funded by @novonordiskfond
link.springer.com/article/10.1...

No matching of physical activity or VO2max means this isn't T2DM, this is an unreliable story.

> 20yr ago Mootha also presented something as T2DM, when online the hidden VO2max data explained all of the OXPHOS story

The astonishing amount of power my little group of "sleuth" friends hold over 20 million scientists. It *is* hard to believe.