Mareike Ludwig

😂

... Don't children adopt behaviors from their parents... Jens is it your left or right shoulder?

first time with this dataset, neuroimaging was mainly done by @petersenm.bsky.social - but we should catch up soon 🤗

I am currently at #ESOC2025 with the @csi-lab.bsky.social to present latest findings on #sleep and cerebral small vessel disease ( #CSVD )

❤️ Big thanks to the whole team for this wonderful dataset including excellent #neuroimaging 🧠

#TaVNS inside the MR scanner IS POSSIBLE! ⚡🧠

I hope that this paper and its guidance on the taVNS MRI set-up will help those planning concurrent #fMRI and #vagusnervstimulation

Checkout our new preprint
osf.io/preprints/ps...

Endless gratitude to @nbkroemer.bsky.social & @glassybrain.bsky.social

Across institutes. One contributing factor is the filling of leadership positions with individuals who lack both leadership knowledge and a genuine interest in this responsible task, focusing instead on their own self-interest and personal ego.

Congrats 💐 and very nice project!

among others with @mjdahl.bsky.social @neusfalgas.bsky.social @mikekelberman.bsky.social

Welcome! You are invited to join a webinar: Neuromodulatory Subcortical Systems PIA: Tiny Dots - Noradrenergic Axon Loss Drives Hyposmia in AD. After registering, you will receive a confirmation email... Early-onset degeneration of hyperactive locus coeruleus axons in the olfactory bulb drives olfactory dysfunction in Alzheimer’s disease via phosphatidylserine-MFG-E8 signaling and microglial clearance...

I am very much looking forward to this week with 2 meetings of the Neuromodulatory Subcortical System PIA:
📌 Tiny dots 21.01.25 12.30am CT (USA) - Noradrenergic Axon Loss Drives Hyposmia in AD
alz-org.zoom.us/webinar/regi...

📌 Year in Review 24.01.25 10am CT (USA) alz-org.zoom.us/webinar/regi...

The thing is, it’s not like the resistance has failed. They set out to impeach him, to convict him for his many felonies, to vote him out of office. They have achieved all of that.

It’s just that it has now turned out that all of those achievements were meaningless. That’s where hopelessness lives.

🧠❤️🤗

📝 Short bursts of taVNS, whether real or sham,led to an increase in pupil dilation and an improvement in memory performance over time likely due to the attention-inducing sensory modulation of electrical stimulation
#taVNS #vagusnerv #vagusnervstimulation #locuscoeruleus #memory #memoryperformance

🚨 STIMULATE TO REMEMBER ? ⚡

Link to publication:
onlinelibrary.wiley.com/doi/epdf/10....

⚡ 3 sec of taVNS (5 mA, 25 Hz, 250 μs) during an emotional memory task

⚡ real (cymba conchae) vs. sham (earlobe) vs. no stimulation trials

📑 Check it out and have a look at the built taVNS-setup & design ⚡👁️ #LocusCoeruleus #vagusnervstimulation #vagusnerv #taVNS #pupillometry

🥜 in a nutshell 2/2: however, there was an attenuation of taVNS-induced pupil dilation when differences in perception of sensations due to stimulation were considered

🥜 in a nutshell 1/2: short bursts of real taVNS and higher intensity led to increased pupil dilation, consistent with phasic iVNS studies in animals

Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception - Scientific Reports Scientific Reports - Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception

🚨Short bursts of taVNS ⚡ & 👁️ pupil dilation - as an indirect measure of #LocusCoeruleus (?!) #vagusnerv #taVNS

Link to publication:
www.nature.com/articles/s41...

I systematically tested different frequencies (10 & 25 Hz) and intensities (3 & 5 mA) during 3 sec of short bursts of taVNS

törööö❤️🐘

😄 Could you find out which dentist that is... sounds tempting 🤪💤

5/5 📈 Moreover, older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally declining LC in ageing.

🧠 Our study shows that assessment of #locuscoeruleus function is a promising biomarker of cognitive aging.

4/5 📈 Increased LC responses were observed during emotionally and task-related salient events, with subsequent accelerations and decelerations in reaction times, respectively, indicating context-specific adaptive engagement of the LC.

3/5 🧠In the present study, high-resolution functional MRI (fMRI), a reversal reinforcement learning task, and dedicated post-processing approaches were used to visualise age differences in LC function (N = 50).

2/5 🧠 In vivo measurements of LC integrity and function are potentially important #biomarkers for healthy ageing and early ND onset.

1/5 The #locuscoeruleus (LC), our main source of #norepinephrine (NE) in the brain, declines with age and is a potential epicentre of protein pathologies in #neurodegenerative diseases (ND).

Functional locus coeruleus imaging to investigate an ageing noradrenergic system - Communications Biology Functional locus coeruleus (LC) imaging revealed that older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally decli...

Functional #locuscoeruleus imaging, #fmri, to investigate an #ageing noradrenergic system

📑 link to paper:
www.nature.com/articles/s42...

🧵 see thread below

Hi - very nice. Could you please add me too?

Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease INTRODUCTION Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across d...

New work from our postdoc Elouise Koops just got published: #locuscoeruleus metabolism is elevated in preclinical Alzheimer’s disease, and provides resilience against cognitive decline! In collaboration with Joyita Dutta (UMass) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Come work with us Are you looking for a job? At neuroMADLAB, we are always looking for passionate and determined neuroscientists to join our growing team.

We plan to recruit a new PhD student, who will work on projects testing the effective neuromodulation (tVNS, ghrelin) of gut-brain interactions in Bonn.

A good command of German is necessary for this position. Please spread the word.
#neuroscience #psychscisky
neuromadlab.com/en/research/...

Germany's best show with great scientists and topics - that was a great evening with @evaschulz.bsky.social and @fmriguy.bsky.social 🧠 and the whole maithinkx team - thank you! Sundays on ZDFneo or ZDF Mediathek