Alexandra Badea

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimers Disease Risk in Humanized APOE Mice Olfactory impairment is a hallmark of early Alzheimers disease (AD), but the underlying mechanisms connecting sensory decline to genetic and environmental risk factors remain unclear. Our integrative ...

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimers Disease Risk in Humanized APOE Mice #NeuroDegeneration 🧪🧠 www.biorxiv.org/content/10.1...

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh

David Cohen: The Father of MEG David Cohen: The Father of MEG traces the life and science of David Cohen, the physicist who launched the field of biomagnetism and introduced the world to the biomedical imaging technology now known ...

The Martinos Center is proud to present the story of David Cohen, the inventor of #MEG and father of #biomagnetism. You can read the biography online, with our compliments, at the address below. Email gboas@mgh.harvard.edu for PDF reprints.

meg.martinos.org/david-cohen-...

www.scopus.com/record/displ...

NIH cancels its first and largest study centered on women The Women’s Health Initiative has produced numerous influential findings

www.science.org/content/arti...

MRI acquisition and reconstruction cookbook: recipes for reproducibility, served with real-world flavour - Magnetic Resonance Materials in Physics, Biology and Medicine MRI acquisition and reconstruction research has transformed into a computation-driven field. As methods become more sophisticated, compute-heavy, and data-hungry, efforts to reproduce them become more...

Most delicious!
Tamir, J.I., Blumenthal, M., Wang, J. et al. MRI acquisition and reconstruction cookbook: recipes for reproducibility, served with real-world flavour. Magn Reson Mater Phy (2025). doi.org/10.1007/s103...

Senior Engineering Physicist - Synex Medical The Basics. This is a full-time position. This is a hybrid position. We'll ask that you spend at least one day per week in the office on a regular basis. A few times per year, there will be a w...

We are hiring a Senior Engineering Physicist to work on building an ultra-compact in vivo NMR/MRI device. Please forward to anyone you think may be interested. Salary range included in the posting. Based in Toronto but hybrid. #NMRchat

careers.synexmedical.com/jobs/5742819...

Την άνοιξη αν δεν την βρεις την φτιάχνεις

Ναι την φτιάχνεις.

Κάθε φορά από την αρχή.

Όλο και πιο ζωντανή.

Όλο και πιο ποτισμένη.

Ναι την φτιάχνεις.

Ο. Ελύτης

Quantitative comparison of femurs in apolipoprotein E mouse models using high-resolution photon-counting micro-CT Apolipoprotein E (APOE) genotype and nitric oxide synthase 2 (NOS2) expression are key genetic factors that influence bone health. While prior studies explored differences in bones by APOE genotype, the role of sex and NOS2 require further investigation. In this study, we acquired micro-CT scans of femurs and analyzed their characteristics in a cohort of mice with variation in age, sex, APOE genotype, and humanized NOS2 (HN) expression. Femurs were extracted from 57 mice and scanned using photon-counting micro-CT with two energy thresholds. Scan data was iteratively reconstructed and decomposed into water and calcium material maps. Trabecular and cortical femur features were computed from calcium maps of femurs using ImageJ’s BoneJ plugin. Statistical analyses of femur features were applied on the entire cohort of mice and on subgroups stratified by sex, APOE genotype, and HN status. Our image quality assessment found that the calcium map has higher contrast to noise ratio than both energy channels of the iterative reconstruction. Differences in bone volume fraction by APOE genotype were found in the whole group, but this result was not reproduced in subgroups stratified by sex or HN status. Analyses in the whole group and in stratified subgroups revealed that the interaction between sex and HN status was a significant predictor of femur features and that HN females tend to have low trabecular bone content. This study illustrates the benefits of photon-counting CT for femur imaging and shows meaningful effects of age, APOE genotype, sex, HN, and their interactions on bone health.

APOE is known for its role in Alzheimer’s —but it also shapes your bones. Our study shows that APOE, immunity, and sex interact to alter bone structure in aged mice. Grateful to Rohan Nadkarni & QIAL team. www.spiedigitallibrary.org/conference-p...
#MRI #Alzheimers #BoneHealth #Neurodegeneration

Neuroimaging Biomarkers of Neuroprotection: Impact of Voluntary versus Enforced Exercise in Alzheimers Disease Models Exercise is a promising strategy for preventing or delaying Alzheimers disease (AD), yet its mechanisms remain unclear. We investigated how exercise influences brain structure, function, and behavior ...

Can exercise shape brain resilience to Alzheimer’s disease?
Our preprint shows voluntary and enforced exercise drive distinct neuroplastic changes in a mouse model—from memory to reward circuit reorganization.
🔗 doi.org/10.1101/2025...
#Alzheimers #Neuroimaging #ExerciseScience

strong endorse!!

Thanks everyone who came to see our trialwise RSA poster.

Preprint went live today!

www.biorxiv.org/content/10.1...

How does exercise and fitness promote healthy brain aging?
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...

Reversible reduction in brain myelin content upon marathon running - Nature Metabolism Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...

www.nature.com/articles/s42...

Lights, fiber, action! A primer on in vivo fiber photometry Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynami…

www.sciencedirect.com/science/arti....

The predictive nature of spontaneous brain activity across scales and species Dimakou et al.’s review examines how spontaneous brain activity across species from C. elegans to humans encodes behaviorally relevant sensory, motor, metabolic, and interoceptive states. They hypothe...

www.cell.com/neuron/fullt...

A human brain map of mitochondrial respiratory capacity and diversity - Nature The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...

www.nature.com/articles/s41...

✅ APOE4 disrupts brain connectivity with aging
✅ High cardiovascular risk (FRS) weakens key connections
✅ Network-specific disruptions highlight early AD vulnerability @NIA @alzassociation.bsky.social

Excited to share our latest paper in Brain Structure and Function! 🧠✨

We explore how age & APOE risk factors impact long-range brain connections using multiscale bundle analysis.

🔗 You can read it here: rdcu.be/eehiz

Excited to join Bluesky today! As an ion channel biophysicist, Professor at Duke Neurobiology, and Director of Graduate Studies I will be sharing my insights. Plus the occasional post of my private life. Please help me connect to my community by sharing this post.

Nvidia’s next chips are named after Vera Rubin, astronomer who discovered dark matter Nvidia CEO Jensen Huang is expected to reveal details about Rubin, the chipmaker's next AI GPU, on Tuesday at the company's annual GTC conference.

"Nvidia is naming its next critical AI chip platform after Vera Rubin, an American astronomer."

www.cnbc.com/2025/03/13/n...

Longitudinal monitoring of the mouse brain reveals heterogenous network trajectories during aging - Communications Biology A longitudinal aging study using fMRI in anesthetized mice suggests brain network changes like humans. Mostly, female mice show a de-differentiation of networks with increased connectivity of prefront...

www.nature.com/articles/s42...

How the NIH dominates the world’s health research — in charts Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.

www.nature.com/articles/d41...

High‐resolution perfusion imaging in rodents using pCASL at 9.4 T Ultrahig-resolution (UHR) pCASL imaging could be highly relevant in myriad animal models of disease and plasticity. We develop a setup enabling UHR pCASL using a cryogenic coil and report increases i...

analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10....

Optimization of Pseudo-continuous Arterial Spin Labeling using Off-resonance Compensation Strategies at 7T The sensitivity of pseudo-continuous arterial spin labeling (PCASL) to off-resonance effects (ΔB0) is a major limitation at ultra-high field (≥7T). The aim of this study was to assess the effectivenes...

pmc.ncbi.nlm.nih.gov/articles/PMC...

I wonder why this is happening ?

I completely missed that Republicans introduced a bill to increase the endowment tax from 1.4% to 21%. If passed, Harvard would go from paying ~$35m to $525m/yr in federal taxes (that’s 8.2% of its current operating expenses)

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

www.nature.com/articles/d41...

My in-person study section, Neuromodulation and Imaging of Neuronal Circuits, was just cancelled.

I mourn not seeing amazing colleagues and doing our part to help the best science move forward.

I mourn the life-saving projects that won't proceed without support.

I mourn the loss of reason.

International Day of Women and Girls in Science | United Nations The purpose of the day is to achieve full and equal access to and participation in science for women and girls.

www.un.org/en/observanc...