Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients - PubMed The term colitis suggests mucosal inflammation as the key event. However, it may be that the disease starts with mucosal hyperproliferation, and inflammation of the impaired mucosa is a succeeding eve...

Biopsy specimens of 30 patients having a normal rectosigmoidal mucosa showed a DAO activity of 22.8 nmol/min g. In 12 UC patients the DAO activity was 2.7 nmol/min g (p = 0.01)

pubmed.ncbi.nlm.nih.gov/2115242/

Action of Serotonin on the Gastrointestinal Tract - Herbert S. Ormsbee, Joseph D. Fondacaro, 1985 Serotonin is localized in the enterochromaffin cells of the gastrointestinal mucosa and within neurons in the enteric nervous system. It can be released into th...

Serotonin from enterochromaffin cells inhibits gastric acid and may act as an enterogastrone; it also stimulates mucus secretion in the stomach and colon

journals.sagepub.com/doi/abs/10.3...

Quorum Sensing Modulates Bacterial Virulence and Colonization Dynamics During an Enteric Infection Quorum Sensing (QS) is a form of cell-to-cell communication that enables bacteria to modify behaviour according to their population density. While QS has been proposed as a potential intervention agai...

The accumulation of Quorum Sensing signals throughout the gut is instrumental in regulating bacterial virulence during infection. This process also enables the regulation of behavior based on the location and stage of infection

www.biorxiv.org/content/10.1...

“Patients started on vedolizumab, should have their kidney function monitored routinely to assess for kidney injury with AIN/ATN being on the differential for AKi if it develops on this medication.”

Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children’s Study The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early i...

Children exposed to indoor cats and dogs during foetal development and early infancy have fewer food allergies

Surprisingly, children exposed to hamsters had significantly greater incidence of nut allergies

journals.plos.org/plosone/arti...

Lactobacillus GG is associated with mucin genes expressions in type 2 diabetes mellitus: a randomized, placebo-controlled trial - European Journal of Nutrition Purpose Recent studies indicate that dysbiosis of gut microbiota and low-grade inflammation are important pathogenic determinants of type two diabetes mellitus (T2DM). The aim of this study is to inve...

“With LGG supplementation, mucin 2 and 3A (MUC2 and MUC3A) gene expressions increased more than ninefolds (p = 0.046 and p = 0.008, respectively) at post-treatment”

link.springer.com/article/10.1...

IDDF2023-ABS-0162 Potassium-rich diet (coconut water) modulates gut microbiome and induces clinical remission in patients with mild to moderate ulcerative colitis: double blind randomized placebo-cont... Background High potassium intake has been associated with decreased risk of inflammatory bowel disease (IBD), and urinary potassium levels have been correlated with disease activity in ulcerative coli...

Coconut water modulated the gut microbiome and was more effective than a placebo in the induction of clinical remission in patients with mild-moderate UC

gut.bmj.com/content/72/S...

Effect of Bifidobacterium infantis 35624 (Align) on the Lactulose Breath Test for Small Intestinal Bacterial Overgrowth - PubMed This study found that 2 weeks of B. infantis 35624 (Align) supplementation affects LBT assessment for SIBO by significantly increasing methane, but not hydrogen, excretion after lactulose administrati...

2 weeks of B. infantis 35624 (Align) supplementation significantly increases methane, but not hydrogen, excretion after lactulose administration

pubmed.ncbi.nlm.nih.gov/29397491/

Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-produ...

Intestinal inflammation severity negatively correlates with the amount of xanthurenic and kynurenic acids, which decreases colitis severity through effects on intestinal epithelial cells and T cells

gut.bmj.com/content/72/7...

Is dietary fiber beneficial or deleterious for patients with IBD? Dietary fibers, known to regulate intestinal inflammation and gut barrier functions, have been avoided by patients with inflammatory bowel diseases (IBD) to avoid flare-ups. However, recent findings s...

When fiber-fermenting microbes are present in an uninflamed gut, fermentation strengthens the intestinal barrier and reduces the inflammatory response. When the gut environment is inflammatory, β-fructans stimulate inflammation

www.gutmicrobiotaforhealth.com/is-dietary-f...

Biofilms are present in more than 1/2 of all patients with IBS and 1/3 of patients with UC and implicates their involvement in disease pathogenesis and provides a strong basis for new diagnostic and treatment opportunities, as well as disease classification.”

www.gastrojournal.org/article/S001...

Cyberlindnera jadinii and Kluyveromyces lactis, two fungi used in food processes, have potential probiotic effects on gut inflammation | mSystems The food industry has always used many strains of microorganisms including fungi in their production processes. These strains have been widely characterized for their biotechnological value, but we st...

Cyberlindnera jadinii and Kluyveromyces lactis, two fungi used in food processes, have potential probiotic effects on gut inflammation

journals.asm.org/doi/10.1128/...

Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice - Nature Microbiology The gut commensal Akkermansia muciniphila regulates food allergy symptoms in a diet-dependent manner in mice.

Akkermansia muciniphila resulted in stronger anti-commensal IgE coating and innate type-2 immune responses, exacerbating food allergy in fibre-deprived mice

www.nature.com/articles/s41...

Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche | PNAS Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of...

Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche

www.pnas.org/doi/10.1073/...

Would love to be added!

Indigo Naturalis may not be able to induce complete "microbial remission,' but a combination treatment that includes probiotics containing members of the Firmicutes phylum that were not restored to normal levels may be beneficial for Ulcerative Colitis

www.gastrojournal.org/article/S001...

Would be great to be added!

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming In the face of mechanical, chemical, microbial, and immunologic pressure, intestinal homeostasis is maintained through balanced cellular turnover, pro…

Expression of AHR in the GI tract has been shown to protect the mouse gut from insults such as DSS induced colitis and Citrobacter rodentium infection. Broccoli can be used as a natural source of AHR - consumption improved resistance to DSS colitis in mice

www.sciencedirect.com/science/arti...

(PFAS) exposure is associated with later occurrence of inflammatory bowel disease

www.cghjournal.org/article/S154...

go.bsky.app/JShNP99

Post below to get added to the list if you are an IBD researcher, educator, or advocate!

The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis Gut microbiota dysbiosis in IgA nephropathy increases mucin-degrading bacteria, resulting in auto-antigen generation.

Gleeson et al. investigated this interaction in patients with and without IgA nephropathy and in mice to show that Akkermansia muciniphila, a species of mucin-degrading bacteria, contributed to autoimmune kidney disease

www.science.org/doi/10.1126/...

Would be great to join!

Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease | Molecular Systems Biology imageimageMACARRoN combines ecological and epidemiological metrics to prioritize metabolic features with potential bioactivity in a phenotype of interest. Its application to inflammatory bowel disease...

Nicotinamide riboside reduced colitis scores in DSS-treated mice

www.embopress.org/doi/full/10....

Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis - BMC Gastroenterology Background Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychologica...

Lower ultra-short-term HRV correlates with worse mucosal healing in ulcerative colitis.

bmcgastroenterol.biomedcentral.com/articles/10....

Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis Betaine as a methyl donor in dietary nutrient is abundant in sugar beets, which can be a potential therapeutic compound to repair damaged colonic barrier for the treatment of ASUC by its antioxidant ....

Betaine Ameliorates Acute Severe Ulcerative Colitis (ASUC) by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis

onlinelibrary.wiley.com/doi/abs/10.1...

Although fibers are typically beneficial in individuals with normal microbial fermentative potential, some dietary fibers (FOS and Inulin) have detrimental effects in select patients with active IBD who lack fermentative microbe activities

www.gastrojournal.org/article/S001...

Identification of environmental factors that promote intestinal inflammation - Nature The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflamma...

Propyzamide, sold by Corteva, amplifies intestinal inflammation through the AHR–NF-κB–C/EBPβ signaling, highlighting its role as an environmental factor in Inflammatory Bowel Disease:

www.nature.com/articles/s41...