50 years ago, King & Wilson published a foundational paper that underlies the cis-regulatory paradigm (CRP) of #DevoEvo #EvoDevo, i.e., that *almost* all morphological evolution is driven by mutations in regulatory elements, rather than proteins, and it all arose from simple misunderstanding π§ͺ π§΅
29.10.2025 00:35 β π 68 π 31 π¬ 7 π 4
Grading is tough. #PhDSky
29.10.2025 16:21 β π 2 π 2 π¬ 0 π 0
The best fiction writer could not make this shit up.
πΈLONG LIVE THE FROGS πΈ
20.10.2025 21:35 β π 91 π 24 π¬ 16 π 4
future grandchild: like shit, from an ass?
me in 30 years: Swear to God. Then he demolished the White House
20.10.2025 21:59 β π 12216 π 2363 π¬ 90 π 49
Listening to rap helps inure you to this by equipping you with a framework that acknowledges the role your haters play in your growth.
15.10.2025 17:11 β π 233 π 27 π¬ 6 π 1
Inside the Improbable, Audacious and (So Far) Unstoppable Rise of Zohran Mamdani
weβll see how his mayoral tenure shakes out but i am convinced that Mamdani has the juice. not just the charisma to win an election but the temperament to govern and the measured pragmatism of someone who genuinely believes what theyβre saying and wants to accomplish real things.
14.10.2025 13:50 β π 16973 π 2421 π¬ 336 π 168
Twenty-four hours a day, seven days a week, I paced in circles like a restless ghost.
The windows were frosted, allowing only a faint suggestion of daylight and nightfall, enough to remind me that time was passing, though I had little sense of how.
The shower water was always cold, and my only amenities were the steel toilet and sink fused together in the corner. It was a miserable existence. Yet, as I soon learned, misery can always be deepened
On September 7th, the warden's office saw fit to move me into something far worse, an even smaller cell, no more than seven by nine feet, coated in filth, reeking of neglect, and utterly devoid of natural light or ventilation.
In that suffocating shoebox, there is no room to walk, no hint of the sun, no trace of humanity. The silence is crushing.
The air feels stale. The walls themselves seem to close in. I keep asking myself: will this barbaric confinement ever end? Is this legal under our Constitution, or have I simply been erased from the protections of due process?
Most haunting of all, will I survive it? With no access to my family, no calls, no emails, and with letters that may never leave this building, I live in total darkness, cut off from the world I once fought to serve.
Let me be blunt: I find Warden Kelly's so-called "protection" not only unpalatable, but cruel and unjustifiable. My time here has opened my eyes to a truth far too many ignore: America desperately needs prison reform.
just found out that about a week ago, while george santos has been in solitary confinement, that he wrote that due to the inhuman conditions he is facing he is now pro prison reform. just unreal stuff honestly
13.10.2025 04:26 β π 5786 π 720 π¬ 293 π 152
Apple Banned an App That Simply Archived Videos of ICE Abuses
Eyes Up's purpose is to "preserve evidence until it can be used in court." But it has been swept up in Apple's crackdown on ICE-spotting apps.
New: Apple banned an app that simply archived videos of ICE abuses. Rather than other apps that record ICE official's real-time location, Eyes Up is to "preserve evidence until it can be used in court." Videos from TikTok etc. Every submission manually reviewed
www.404media.co/apple-banned...
08.10.2025 19:13 β π 1313 π 670 π¬ 54 π 60
Whaaa? The guy who pimped lies about Iraq's WMD for years and when the lies were so obvious, so debunked declared himself a "hero in error" and refused to discuss it ever again has absolutely no journalistic ethics?
Color me shocked pink.
08.10.2025 15:47 β π 15 π 7 π¬ 0 π 0
Reminder that neither David "Axis of Evil" Frum nor The Atlantic are your friends.
08.10.2025 19:14 β π 8 π 3 π¬ 1 π 0
I do not regret to inform you that we are going to win
27.09.2025 01:10 β π 867 π 103 π¬ 18 π 7
shoutout to bread; gotta be up there for best human invention
19.09.2025 19:29 β π 213 π 22 π¬ 9 π 6
Holmes:
"You are the breeze in desert for me."
"My water."
"And ocean."
"Meant to be only together tiger."
Balwani: "OK"
still remains the funniest thing to come out of the Theranos trial
15.09.2025 02:39 β π 1950 π 284 π¬ 18 π 30
Transgender people are owed a retraction and apology from @wsj.com. The lie has already become canon to millions and it seems the least they could do.
12.09.2025 14:23 β π 8224 π 2253 π¬ 79 π 48
Not gonna put the person who said this on blast, but no, the British press lying about trans people is not βAmerica-brainedβ. This is a particular obsession of our press that extends way beyond the typical partisan lines it does in other countries
12.09.2025 15:04 β π 81 π 13 π¬ 4 π 0
WSJ just retracted its report that the shooterβs ammo was engraved with βtransgender and anti-fascist ideology.β
It smelled like bullshit from the beginning, and every conservative who ran with it should be shamed into obscurity.
12.09.2025 01:35 β π 7178 π 1826 π¬ 268 π 213
"Graphic from the NRA with a red border and dark blue background. White and yellow text states: 'The NRA supports the Second Amendment rights of all law abiding Americans to purchase, possess and use firearms. NRA does not, and will not, support any policy proposals that implement sweeping gun bans that arbitrarily strip law-abiding citizens of their Second Amendment rights without due process.' The NRA logo is at the bottom. The tweet caption reads: 'The Second Amendment isnβt up for debate.'"
Oh my god, Trump actually got the NRA to come out to defend trans people owning a gun.
05.09.2025 16:12 β π 12818 π 3019 π¬ 500 π 1014
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.
07.09.2025 20:36 β π 146 π 67 π¬ 0 π 5
something that drives me nuts is how legacy media will write that "scholars question legality" of a trump administration action when there is not a shred of evidence that it is in fact legal. it leaves room for the federal government to manufacture a legal justification when literally none exists.
04.09.2025 17:41 β π 3722 π 723 π¬ 77 π 33
The Washington Post is currently burying coverage of a top-20 mass protest in American history under eight opinion pieces and 10 stories, including "We ranked 5,700 holidays. Which oneβs most popular on your birthday?" and "This California city plans to spend nearly $400,000 to get rid of its geese"
01.09.2025 21:01 β π 101 π 21 π¬ 2 π 1
@npr.org the term is "ethnic cleansing."
01.09.2025 21:11 β π 1 π 0 π¬ 0 π 0
this dude literally lives in the same area as me and i see these checkpoints everywhere. heβs been saying this on podcasts lately and itβs just false. i do not know why he keeps saying it
27.08.2025 22:50 β π 1033 π 141 π¬ 48 π 13
I cannot possibly explain fully what incredibly dark, dangerous, and cynical sh*t this is β literally using the playbook of our enemies against a steadfast ally FOR ABSOLUTELY NO REASON except making b-reel propaganda
Iβm definitely going to need some more detail on the who, the how, & the funding
27.08.2025 18:28 β π 212 π 58 π¬ 14 π 3
Just practically speaking... A lot of trans young ppl who can grit their teeth and make it to 18 aren't gonna make it to 25.
25.08.2025 23:49 β π 718 π 182 π¬ 12 π 7
You know it's a power play, not "for a crime crackdown." Repeating claims you know are false is journalistic malpractice.
25.08.2025 06:16 β π 5 π 0 π¬ 0 π 0
Again:Journalists are not stenographers. We are to get information, report and verify the facts, and then report the reality not the talking point. What Trump is doing in DC and threatening in cities is NOT a crime crack down because he says it is. Donβt regurgitate. Report the truth not propaganda.
24.08.2025 17:34 β π 1271 π 395 π¬ 35 π 16
Should Democrats Throw Trans People Under the Bus?
Hereβs Why It Would Be Bad Politics
since Bluesky is chock full of Newsom-stan-bots insisting that "Dems should compromise on trans issues", I will re-up my November essay about why this is not only immoral & unempirical, but BAD POLITICS. Dems WILL LOSE if they do this, here's why (no paywall): juliaserano.medium.com/should-democ...
24.08.2025 14:52 β π 1699 π 591 π¬ 28 π 27
Alt text: Screenshot from a White House webpage. The text states that the National Portrait Gallery was set to feature a βpainting depicting a transgender Statue of Libertyβ before the artist withdrew it. Below, the artwork shows a dark-skinned figure with bright pink hair, wearing a blue gown with a thigh-high slit, holding a torch made of orange flowers against a pink background.
The Smithsonian tried to avoid being targeted by the Trump administration by not exhibiting a portrait of a Black trans statue of liberty. They are being targeted for it anyways.
Capitulation never works.
22.08.2025 20:28 β π 926 π 250 π¬ 10 π 12
It's amazing how little it takes for liberals to abandon civil rights. Conservatives poured money into making trans people a culture war fixation and transphobia still isn't actually an electoral winner, but liberals are ecstatic to "make a tough sacrifice" and mulch us to run right and lose again.
21.08.2025 03:49 β π 2318 π 574 π¬ 54 π 21
*derp, misspoke, "acts of genocide" is also about the Genocide Convention
22.08.2025 13:26 β π 2 π 0 π¬ 0 π 0
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