@replifate.bsky.social
We go live!!!
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE ๐ฅณ (but mandatory) - we hope to see many in Munich ๐บ @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances
DOI: 10.1016/j.tibs.2025.07.004
๐ La artista e investigadora Helen Pynor estuvo como Artist in Residence en el CBM con el proyecto europeo RepliFate. Su trabajo combina arte y biologรญa molecular para plantear nuevas preguntas sobre la vida.
๐ Lee la entrevista completa: www.cbm.uam.es/index.php/20... @FateRepli
Our first bachelor student successfully defended her thesis!
An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats!
Many thanks to Panos Galanos (SDU) for serving as external examiner and for the thoughtful evaluation.
Welcome to the academic club, Amรฉlie!
This Tuesday, RepliFate Fellows traded pipettes for pitch decks in a full-day #entrepreneurship workshop hosted by Lead Discovery Center GmbH.
๐กA great opportunity for our fellows to think differently about impact, #innovation, and #business development.
Sometimes DNA replication hits a ๐ roadblock.
Cells donโt stop; they take clever detours (DNA damage tolerance) ๐๐จ to keep genomes intact.
Thatโs the focus of our new review in @cp-trendsbiochem.bsky.social:
โJust bypass it: mechanisms of DNA damage toleranceโ
๐ doi.org/10.1016/j.ti...
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
New cool research alert!
Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA.
Read the full study: doi.org/10.1038/s414...
Another exciting research article from a member of the #RepliFate network!
The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis.
Check out their findings here: doi.org/10.1016/j.ce...
Just published!
Lecona (@emlecona.bsky.social ) & Mรฉndez #RepliFate labs show that VCP/p97 removes Pol ฮฑ/primase from chromatin to avoid excess ATR activation during normal #DNAreplication
VCP/p97 = checkpoint gatekeeper!
Read the full study: doi.org/10.1038/s414...
More info about Helen Pynor's art work here: www.helenpynor.com
26.06.2025 10:00 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0This unique collaboration aims to spark new dialogues between scientific research ๐งฌ and contemporary art ๐ญ, culminating in experimental works and public engagement activities that translate complex biology into compelling artistic experiences.
26.06.2025 10:00 โ ๐ 2 ๐ 0 ๐ฌ 1 ๐ 0
Weโre excited to welcome artist Helen Pynor to @cbm-csic-uam.bsky.social as part of the #RepliFate artist-in-residence program! ๐จ๐งฌ
From June 24โJuly 5, sheโll explore how #DNAreplication shapes cell fate & cancer, bridging science & art with our researchers.
#SciArt #ArtInScience
Frogs in the lab? Yep! ๐ธ
This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.
Our labโs a little more crowded (and a lot more curious) this week! ๐ง ๐ธ
Weโre thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts.
They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.
#EuropeDay2025
On May 8, Emilio Lecona @emlecona.bsky.social and PhD students Ran Tong (@csic.es) & Scott Brian Churcher (@cbm-csic-uam.bsky.social) presented our network to students to show how we train researchers to study DNA replication in the fight against cancer ๐ก๐งฌ
๐ฌ Science Through an Artistic Lens๐จ
๐งฌLed by Prof. Maria-Elena Torres-Padilla, the #RepliFate Artist-in-Residence Program brings #artists and #scientists together.
๐ t1p.de/j5pi8
@epihmgu.bsky.social @metorrespadilla.bsky.social @ec.europa.eu @annadumitriu.bsky.social @replifate.bsky.social
Great initiative from the CSIC!
We're proud to see RepliFate science shared with the public on #EuropeDay2025 โ science belongs to everyone!
๐ #ClimateActionDay is here!
For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future
At BRIC @bric-ucph.bsky.social, weโre putting words into action!
Small changes can make a big impact ๐ฑ
#GreenLabs #SustainableScience
Itโs time for new duo: Julius Thomas & his PI Lorenza Penengo from the University of Zurich.
They study the ISG15 system in DNA replicationโbut thereโs more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? ๐
Weโre kicking off our RepliFate introductions with @Phuc and her PI, @sylvie-noordermeer.bsky.social ! As part of the RepliFate network, they are contributing to exciting research in double-strand break (DSB) repair. Wanna know more about their work, hobbies, and fun facts? Check out their profiles!
25.02.2025 08:09 โ ๐ 6 ๐ 3 ๐ฌ 0 ๐ 0Her goal? To observe, learn, and draw inspiration from the molecular world we study, translating the complexities of DNA replication into artistic expression. #SciArt
21.02.2025 09:57 โ ๐ 3 ๐ 0 ๐ฌ 0 ๐ 0
๐จ ๐ฌ Science Meets Art
This week, we are excited to welcome Pei-Ying Lin to the @duxinlab.bsky.social as part of the RepliFate Artists in Residence program. Pei will spend two days immersed in our lab routine.
Over the coming weeks, weโll spotlight both PhD students and PIs, sharing not only their research interests but also a glimpse into their personalities.
20.02.2025 09:11 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0Ever wondered where a scientist spends most of their time in the lab? Or what they would be doing if they werenโt researchers?
We are excited to launch a series introducing the RepliFate researchers driving innovation in DNA Replication and Cell Fate.
