Duxin lab

Events for February 2026 06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

We go live!!!

Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field

AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social

@replifate.bsky.social @epicrossborders.bsky.social

replifate.eu/event/meetin...

'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances

DOI: 10.1016/j.tibs.2025.07.004

Our first bachelor student successfully defended her thesis!
An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats!

Many thanks to Panos Galanos (SDU) for serving as external examiner and for the thoughtful evaluation.

Welcome to the academic club, Amélie!

The last EDRA webinar of the year is today at 4 pm with Julian Stingele presenting the role of RNA damage in chemotherapy, followed by Andre Bortolini Silveira on BER and MMR converge, and Nicola Pietro Montaldo on Mitochondrial DNA Repair and Parkinson's Disease

@edra-webinars.bsky.social

Don’t miss it! The 12th Conference on Responses to DNA Damage will take place in Egmond aan Zee from 19–24 April 2026.

📅 Registration is open! Deadline for abstracts: Jan 10, 2026.

More details & provisional program here: dnarepairmeeting-egmond2026.com

Fascinating paper from Krietenstein, Groth & Lukas groups showing how cells can repair a DSB, but its 'echo' can persist leading to postrepair chromatin fatigue

Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.

A big congrats to Jonas for driving this work forward, great to see the results out!

👉 10.1016/j.molcel.2025.09.006

BRIC Day with the theme collide across each other — all about sparking new intra-institute collaborations.

Kickoff with a keynote from Rasmus Rabøl (Klifo) and a buzzing poster session full of science-in-the-making!

@bric-ucph.bsky.social

Today we swapped pipettes for putters.

Day 2 retreat highlight: realizing that hitting the fairway is way harder than hitting a replication fork 😅

Off to Nord Sjælland with the Miller lab @tcr-miller.bsky.social for our joint retreat! Exciting brainstorming, bonding, and a little hygge ahead.

First challenge: design your next @natureportfolio.nature.com article 🚀

What makes #cshldnarep special isn’t just the cutting-edge, top-notch science; it’s the chance to meet the authors of the papers we build on every day, exchange ideas, and feel part of this community.

Heading home exhausted, grateful, full of ideas and renewed motivation to push my project forward!

Our PhD student @martaolivasantiago.bsky.social and postdoc @amitash.bsky.social presented their posters on #cshldnarep, turning data into an insightful dialogue.

Huge thanks to everyone who stopped by our poster!

This week we’re at CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.

Sometimes DNA replication hits a 🛑 roadblock.
Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact.

That’s the focus of our new review in @cp-trendsbiochem.bsky.social:
“Just bypass it: mechanisms of DNA damage tolerance”

🔗 doi.org/10.1016/j.ti...

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

New cool research alert!

Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA.

Read the full study: doi.org/10.1038/s414...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...

Just published!

Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication

VCP/p97 = checkpoint gatekeeper!

Read the full study: doi.org/10.1038/s414...

🎉 Congratulations to SUND's new professors!

The Faculty of Health and Medical Sciences, @ucph.bsky.social celebrated 23 newly appointed professors.

Through their dedicated work, they contribute every day to the development of the university, the healthcare system, and society at large.

🌿 Off to Hillerød for the 2025 MoMeD Summer School!

Our PI Julien Duxin -as head of the MoMeD PhD Programme at @ucph.bsky.social- joins our PhD students and many others for 2 packed days of science, networking, and inspiration.

Looking forward to connecting and exchanging ideas across fields!

Frogs in the lab? Yep! 🐸

This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.

Our lab’s a little more crowded (and a lot more curious) this week! 🧠🐸

We’re thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts.

They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.

Tenure-track Research Group leader position in translational cancer research at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital A group leader position at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital is open for appointment as soon as possible. The position is av

🎯 A tenure-track group leader position in translational cancer research is now open at Finsen Laboratory.

Come join an excellent and friendly research environment combining both the Rigshospitalet and the KU @ucph.bsky.social affiliated groups

candidate.hr-manager.net/ApplicationI...

#CBC

Chromosome Biology Club is back today!

Join us for two exciting talks:
🧬 Christian Nielsen (CCS/ICMM) on the distinct roles of condensins I & II in mitotic chromosome mechanics

🧬 Judit Pilmark (BRIC) on mutational signatures linked to NER deficiency

Starting at 4.45 pm
Followed by pizzas and beer

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ - Nature Communications The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range compl...

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80.
www.nature.com/articles/s41...

FEBS|EMBO Women in Science Awardees – Nominate for the Women in Science Award – EMBO Nominees should be female scientists working in an EMBC Member State or FEBS member country, who have made outstanding contributions to life sciences research and significantly advanced our…

The FEBS | EMBO Women in Science Award aims to highlight the major contributions made by female scientists to #LifeSciences research. Winners of the award are inspiring role models for future generations of #WomenInScience

Nominate a scientist by 15 May: www.embo.org/the-embo-com... 🧪

53BP1/RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes. DNA double strand breaks (DSBs) are the effective lesion of cancer radiotherapy and induce gene editing. 53BP1 accumulates at DSBs and is implicated in end joining (EJ) repair, but its influence on DS...

New preprint from the lab @kaelamakins.bsky.social Genetic interactions between 53BP1-RIF1 and DNA-PKcs for DSB repair outcomes. www.biorxiv.org/content/10.1...

RNA transcripts serve as a template for double-strand break repair in human cells - Nature Communications DNA double-stranded breaks threaten genome stability. Here, the authors show that transcript RNA serves as a repair template in human cells and identify Polζ as a key factor in RNA-templated DSB repai...

Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5)
🔗 www.nature.com/articles/s41...
#GenomeInstability #DNARepair #RNA #CRISPR #DSB

Today we celebrated #EuropeDay2025 showing the work we do at the RepliFate Doctoral Network in the public library Eugenio Trías @cbm-csic-uam.bsky.social @genomefun.bsky.social

ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart | PNAS The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserv...

🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks
www.pnas.org/doi/abs/10.1...

🌍 #ClimateActionDay is here!

For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future

At BRIC @bric-ucph.bsky.social, we’re putting words into action!

Small changes can make a big impact 🌱

#GreenLabs #SustainableScience