García Knight Lab

We are deeply saddened by the passing of Professor Sir Nicholas White @moru-mip.bsky.social

Nick was a visionary in #malaria treatment whose work transformed global health.
He will be remembered with great respect and affection

Read our tribute 👉 www.tropicalmedicine.ox.ac.uk/news/profess...

January cover of The Lancet Microbe

Our January issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #influenza #H5N1 #AMR #Bordetella #pertussis #Yaws #Treponema #MDA #Hpylori #SARS-CoV-2

#IDSky #ClinMicro #OA

Gonna use this in my immunology lecture

TRAVEL-ASSOCIATED CHIKUNGUNYA VIRUS INFECTION, MEXICO, 2025 In November 2025, a traveler from Cuba tested positive for chikungunya virus upon arrival to Mexico. The virus belonged to the East-Central-South-African lineage, clustering with a clade prevalent in ...

A travel associated CHIKV case in Mexico belonging to the ECSA lineage. Mexico hasn't had a CHIKV outbreak since the 2015/2016 Asian lineage epidemic. Is local transmission occurring?
www.medrxiv.org/content/10.6...

No se han actualizado los casos oficiales de chikungunya en Mexico en lo que va del año. Existe el riesgo de que inicie un nuevo brote en el país.

TRAVEL-ASSOCIATED CHIKUNGUNYA VIRUS INFECTION, MEXICO, 2025 In November 2025, a traveler from Cuba tested positive for chikungunya virus upon arrival to Mexico. The virus belonged to the East-Central-South-African lineage, clustering with a clade prevalent in ...

Los nuevos casos del virus de chikungunya en México están asociados al linaje ECSA, el cual no se había detectado en el país, pero es el responsable de un brote extenso en Brasil y, probablemente, en Cuba. Nuestro estudio al respecto. www.medrxiv.org/content/10.6...

Welcome! You are invited to join a meeting: Genomic Surveillance & Pathogen Data Sharing: A New Era for Scientific Diplomacy. After registering, you will receive a confirmation email about joining the... Welcome! You are invited to join a meeting: Genomic Surveillance & Pathogen Data Sharing: A New Era for Scientific Diplomacy. After registering, you will receive a confirmation email about joining the...

Very much looking forward to my fireside chat with @syramadad.bsky.social next Thursday at 1pm PST at the Belfer Center @harvardkennedy.bsky.social on "Genomic Surveillance & Pathogen Data Sharing: A New Era for Scientific Diplomacy".

Virtual, so come join us!

harvard.zoom.us/meeting/regi...

New research article

#SARS-CoV-2 infectious shedding and rebound among adults with and without oral #antiviral use: two case-ascertained prospective household studies

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #ViroSky #OpenAccess #OA

Fresh conflicts erupt around giant database for flu and COVID-19 sequences Critics say “autocratic” behavior by GISAID could hamper response to a future pandemic

"She and Chen sent GISAID three emails in the weeks after, but never received any response. (GISAID says the emails came from Chen, whereas its agreement was with Stadler.)"

www.science.org/content/arti...

Anuran genome size evolution is driven by relatively recent retrotransposon activity and by life history - BMC Genomics BMC Genomics - Transposable elements (TEs), often referred to as ‘selfish genetic elements’, hijack their host’s genetic machinery to replicate themselves within the host genome,...

#TEsky Anuran genome size evolution is driven by relatively recent retrotransposon activity and by life history doi.org/10.1186/s128...

Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species Author summary Bats are important to study as they are reservoirs for many viruses that can cause severe disease in humans. Notably, bats often show no clinical symptoms when infected with these virus...

Just in time for Christmas, here is the latest paper from the lab! Great work from @leagaucherand.bsky.social and Hugo Marie, with help from Julie Cremaschi. Funded by @frm-officiel.bsky.social, @agencerecherche.bsky.social

journals.plos.org/plospathogen...

@cnrsbiologie.bsky.social @unistra.fr

YouTube video by NEJM Group Measles | NEJM

A new Double Take video reviews evidence-based recommendations on measles prevention and management and explores commonly asked questions about the measles virus and infection. Watch on YouTube: youtu.be/PI6M680p9i0

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature Communications Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.

🧵 Thread on our new @natcomms.nature.com paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11) www.nature.com/articles/s41...

Hiding in plain sight: Genomic and phenotypic characterization of mosquito-borne Bussuquara virus Author summary After decades of being considered negligible pathogens, multiple mosquito-borne viruses, such as Zika and Mayaro, are now recognized as significant human health threats across the neotr...

Delighted to see our latest publication on neglected orthoflaviviruses been published today. Great team work led by Rosie Steck and stay tuned for more soon... journals.plos.org/plosntds/art...
@utmbnews.bsky.social @astmh.bsky.social @mauriciolnogueira.bsky.social @sbvirologia.bsky.social

Experimental infections reveal unexceptional viral tolerance in bats Bats are a conspicuous source of zoonotic viruses with pandemic potential. A common explanation for bats being ‘special’ viral reservoirs is their ability to coexist with viruses without suffering ove...

Love this! (Thanks to @blongdon.bsky.social for altering me!)
www.biorxiv.org/content/10.1...

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...

www.nature.com/articles/s41... 🧪

Scientists crossed a cheetah with a crab.

It didn’t go well, things went sideways real fast

Genomic Evidence for a Novel Introduction and Intra-host Diversity of DENV-2 in Dar es Salaam, Tanzania https://www.biorxiv.org/content/10.1101/2025.11.17.688789v1

Insights into infectious diseases through ancient pathogen genomics Nature Reviews Microbiology, Published online: 17 November 2025; doi:10.1038/s41579-025-01259-7In this Review, Kocher, Krause and Spyrou explore how ancient pathogen genomics is providing new perspectives on the history and evolution of infectious agents. They show how ancient DNA has revealed the aetiology and unfolding of historic outbreaks, pathogen evolutionary timescales, patterns of dissemination and functional evolution, and discuss existing limitations and perspectives of the field.

New online! Insights into infectious diseases through ancient pathogen genomics

HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements AbstractSummary. Endogenous viral elements (EVEs) offer valuable insights into virus and host evolution, but their detection remains computationally and bi

I'm excited to introduce our new workflow for detecting endogenous viral elements - HI-FEVER. 🖥️🧬

academic.oup.com/bioinformati...

🧵

Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!

Is there a hashtag for STEM internships?

Merck is accepting applications for internships in cell biology and assay development, immunogenicity, protein metabolism, biostatistics, vaccine communications, DMPK, and discovery and process chemistry.

A US citizen filmed federal agents smashing his car window, as authorities begin a surge of immigration enforcement operations in North Carolina.

The Honduran-born Charlotte resident filed a police report after the officers let him go.

Ecology and spread of the North American H5N1 epizootic - Nature The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...

Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...

Why surveillance is important? 4 years ago we predicted a CHIKV outbreak by detecting its silent circulation (lnkd.in/gx7-4ZeQ). Today, the team @mauriciolnogueira.bsky.social provided a genomic and clinical time map of the massive CHIKV outbreak of 2024 in the area. #FAMERP #SBV #ASTMH #UTMB #ACAV

NIH Directors: The World Needs a New Pandemic Playbook The old one failed to cope with Covid and may even have caused it.

A new approach to pandemic preparedness:

1️⃣ Stop preparing for pandemics
2️⃣ Rewrite history of the last major pandemic
3️⃣ Go to the gym

Simple - 🤷‍♂️.

www.city-journal.org/article/nih-...

Nice looking review by @ben-parker.bsky.social Paul Rozo-Lopez "Heritable Viruses as Hidden Drivers of Insect Phenotypes and Evolution" doi.org/10.1146/annu...

Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations - Nature Ecology & Evolution A search for analogues of the human SAMD9/9L antiviral genes identifies convergent evolution of this gene family in the bacterial and animal kingdoms, with species-specific and recent genomic signatur...

📖Latest from the lab:
Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶‍♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com

Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n

www.nature.com/articles/s41...

Insertion of an invading retrovirus regulates a novel color trait in swordtail fish For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...

I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A

HEAS Seminar Series - Ancient Genomics - HEAS As part of the HEAS Seminar Series in Ancient Genomics Maria C Avila-Arcos from National Autonomous University of Mexico will give a talk on Paleogenomic evidence of patogen introductions to Mexico fo...

We are looking forward to welcoming Maria Avila Arcos @paleogenomics.bsky.social to #HEASVienna for a #HEASSeminar in #AncientGenomics next Monday at the later than normal time of 11:45 CET.

@peregx9.bsky.social

Registration for online and in-person participation in on our website 👇🔗