Plenty of work required to rigorously test the proposed hypothesis but my initial thoughts are this perspective by Adrian Bird in @cp-molcell.bsky.social may well be the most significant conceptual advance in the 3D genome organisation field in years:
www.sciencedirect.com/science/arti...
Wrapping up my first week as a postdoc in the @meleckmas.bsky.social lab at @petermaccc.bsky.social!
Excited to be diving into epigenetic plasticity in cancer and looking forward to working with a fantastic team!
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#ChromatinSky @nmaziak.bsky.social
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#ChromatinSky @nmaziak.bsky.social
We have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ