EvoluChem

Synthesis, Characterization, and Catalytic Activity of Ni(0) (DQ)dtbbpy, an Air-Stable, Bifunctional Red-Light-Sensitive Precatalyst Despite a well-established and growing body of work on nickel(0) precatalysts, the potential of nickel(0) complexes as bifunctional precatalysts remains underexplored. In this study, we synthesized, c...

The original paper can be found here: pubs.acs.org/doi/10.1021/...

Our latest blog post is up. A look at a recent paper with red LEDs and nickel photochemistry. hepatochem.com/a-nickel-for...

Really excited to see this amazing work out in ChemRxiv from our #ChemCollab between the @uwyoongroup.bsky.social @tehshik.bsky.social and #PfizerChemistry
Photochem-mediated oxygen migration into sp3 bonds delivering small ring ethers as well as an OH - methylene transposition
#ChemSky 1/

2024 Photochemistry Year in Review Looking back on the past year in photochemistry, we want to recognize 24 of our favorite papers that tickled our brains in 2024.

Check our list of our favorite photochemistry papers from 2024, now on our blog page. Send us your favorites as well.

hepatochem.com/2024-photoch...

HepatoChem did it again. more diversity, more equality and more inclusion of lights. we got the power from 254 nm to 808 nm.

2024 Photochemistry Year in Review Looking back on the past year in photochemistry, we want to recognize 24 of our favorite papers that tickled our brains in 2024.

Check our list of our favorite photochemistry papers from 2024, now on our blog page. Send us your favorites as well.

hepatochem.com/2024-photoch...

At the Speed of Light: The Systematic Implementation of Photoredox Cross-Coupling Reactions for Medicinal Chemistry Research The adoption of new and emerging techniques in organic synthesis is essential to promote innovation in drug discovery. In this Perspective, we detail the strategy we used for the systematic deployment of photoredox-mediated, metal-catalyzed cross-coupling reactions in AbbVie’s medicinal chemistry organization, focusing on topics such as assessment, evaluation, implementation, and accessibility. The comprehensive evaluation of photoredox reaction setups and published methods will be discussed, along with internal efforts to build expertise and photoredox high-throughput experimentation capabilities. We also highlight AbbVie’s academic–industry collaborations in this field that have been leveraged to develop new synthetic strategies, along with discussing the internal adoption of photoredox cross-coupling reactions. The work described herein has culminated in robust photocatalysis and cross-coupling capabilities which are viewed as key platforms for medicinal chemistry research at AbbVie.

As a preview to our soon to post list of our 24 favorite papers from 2024, this work on photochemistry at the Medicinal chemistry department at AbbVie.

Our latest post: We were intrigued by the idea of pulsed LED irradiation in photoredox chemistry so wrote about it here.

hepatochem.com/pulsed-light...

Investigating the Effects of Pulsed LED Irradiation in Photoredox Catalysis: A Pilot Study This study examines the effects of pulsed light-emitting diode (LED) irradiation across five representative photoredox reactions employing six established photocatalysts. The primary objective of this investigation was to develop a better understanding of the potential effects and broader scope of pulsed irradiation in photoredox catalysis, which the results suggest may influence reaction progress positively, negatively, or negligibly. These effects appear to vary depending on the specific reaction, the identity of the photoredox catalyst and can even differ between substrates. Accordingly, unraveling the fundamental mechanistic basis of these effects is both challenging and nuanced; however, our results do highlight the importance of properly considering the Bunsen–Roscoe Law during photoredox reaction design.

The paper that inspired the article can be found in Organometallics here:

pubs.acs.org/doi/abs/10.1...

Our latest post: We were intrigued by the idea of pulsed LED irradiation in photoredox chemistry so wrote about it here.

hepatochem.com/pulsed-light...

As an example, our most recent post on our photochemistry blog was a piece we put together on the chemistry of the rainbow. 9 different reactions with 9 different wavelengths. hepatochem.com/photochemist...

Hello Bluesky! We haven't posted in the old place in about a year but we thought we'd give Bluesky a try. Expect the occasional link to our thoughts on photochemistry and links to our favorite papers. Blue lights on Bluesky seem like a great fit.