Reid Alderson

Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application?

Join the 10th European Solid-State NMR Summer School❗️

🗓️ October 20-24, 2025 | Garching, Germany

📌 Application Deadline: 01.09.2025

www.bio.nat.tum.de/ocb/upcoming...

#NMRchat #BioNMR

BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR

For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...

A general substitution matrix for structural phylogenetics. Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

Job details Job details

🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers

> Malene R. Jensen @ IBS Grenoble Research team of CNRS research director Malene Ringkjøbing Jensen at the Institut de Biologie Structurale, Grenoble, France

Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...

A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery

www.nature.com/articles/s41...

Still unclear, indeed. I had read a score of 0.7 in your original message but now see that it was 7.0 — sorry about that!

Maybe they reweighted the 0-1 scale?

Hi Roland, I wonder if this could be the Conservation of Interaction Orientation (CIO) score (0-1) that is mentioned near the end of the Results section? It is derived from geometric analysis of interacting superfamily pairs (ISPs) (Fig 5D, 5E) with a citation to the CIO reference in the methods

Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.

www.nature.com/articles/d41...

SHARK‐capture identifies functional motifs in intrinsically disordered protein regions Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where moti...

Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....

Thank you, Lukas!

#NMR 🧲

PhD Position in Structural Biology (f/m/x)

An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details.

jobs.helmholtz-muenchen.de/jobposting/b...

#science #PhD #research

Congratulations, Woonghee! Very well deserved recognition of your work and your group’s research

Postdoctoral Research Associate in Disordered Protein Interactions

We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch!

3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...

🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223 Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

Very exciting to see, Gogs! Congratulations and looking forward to seeing Bind develop into the future

NMR will be a cornerstone of our experimental toolkit at Bind. We're developing advanced NMR methods enhanced by AI-based tools to rapidly illuminate disordered protein interactions in powerful new ways. Find out more: bindresearch.org #NMRChat #AI 🧲

Delighted to announce @tlhr.bsky.social, @g-heller.bsky.social and I are building the UK’s first FRO @bindresearch.org with the goal of making disordered proteins druggable. Interested in doing breakthrough open science in an innovative organisation in Central London? We’d love to hear from you!

We’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.

Accurate Stoichiometry Prediction of Protein Complexes by Integrating AlphaFold3 and Template Information https://www.biorxiv.org/content/10.1101/2025.01.12.632663v1

2025 EAS Award for Outstanding Achievements in Magnetic Resonance - Eastern Analytical Symposium Professor Lewis E. Kay is a molecular biophysicist recognized for his work in the development and application of solution nuclear magnetic resonance spectroscopy. […]

Professor Lewis E. Kay @lek-lab.bsky.social @uoft.bsky.social to receive the 2025 Eastern Analytical Symposium Award for Outstanding Achievements in Magnetic Resonance eas.org/eas-award-fo... #NMRnews #NMRchat #NMR 🧲

EDUCATION CORNER: Molecule of the Month: Celebrating  25 Years of Storytelling and Announcing New Beginnings After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month series.  Janet Iwasa will be continuing the series for PDB-101.

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service.
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...