Reid Alderson

We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

NMR TITAN user survey This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...

I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat

BPS2026 Annual Meeting | Biophysical Society The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI.  This year’s program…

Get important feedback from your community and move your work forward. Share your research at #bps2026!

Submit an abstract today buff.ly/oOjstk6

Helmholtz Munich Joins Germany’s Instruct-ERIC Centre for Structural Biology

#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬

Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.

👉 Read more: t1p.de/pjtyv

Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...

Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲

Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application?

Join the 10th European Solid-State NMR Summer School❗️

🗓️ October 20-24, 2025 | Garching, Germany

📌 Application Deadline: 01.09.2025

www.bio.nat.tum.de/ocb/upcoming...

#NMRchat #BioNMR

BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR

For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...

A general substitution matrix for structural phylogenetics. Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

Job details Job details

🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers

> Malene R. Jensen @ IBS Grenoble Research team of CNRS research director Malene Ringkjøbing Jensen at the Institut de Biologie Structurale, Grenoble, France

Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...

A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery

www.nature.com/articles/s41...

Still unclear, indeed. I had read a score of 0.7 in your original message but now see that it was 7.0 — sorry about that!

Maybe they reweighted the 0-1 scale?

Hi Roland, I wonder if this could be the Conservation of Interaction Orientation (CIO) score (0-1) that is mentioned near the end of the Results section? It is derived from geometric analysis of interacting superfamily pairs (ISPs) (Fig 5D, 5E) with a citation to the CIO reference in the methods

Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.

www.nature.com/articles/d41...

SHARK‐capture identifies functional motifs in intrinsically disordered protein regions Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where moti...

Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....

Thank you, Lukas!

#NMR 🧲

PhD Position in Structural Biology (f/m/x)

An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details.

jobs.helmholtz-muenchen.de/jobposting/b...

#science #PhD #research

Congratulations, Woonghee! Very well deserved recognition of your work and your group’s research

Postdoctoral Research Associate in Disordered Protein Interactions

We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch!

3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...

🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223 Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

Very exciting to see, Gogs! Congratulations and looking forward to seeing Bind develop into the future

NMR will be a cornerstone of our experimental toolkit at Bind. We're developing advanced NMR methods enhanced by AI-based tools to rapidly illuminate disordered protein interactions in powerful new ways. Find out more: bindresearch.org #NMRChat #AI 🧲