Emmanuel Levy's lab

Global comparative structural analysis of responses to protein phosphorylation - Nature Communications Phosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphory...

Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications!

www.nature.com/articles/s41...

Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧
Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social
www.sciencedirect.com/science/arti...

Tenure-track Assistant Professorship in #Quantitative #Cell #Biology at the ICB @unibern. Apply until 17 October. Combination of theory/computation and experiments particularly encouraged. Please repost!

www.nature.com/naturecareer...

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social

This month's cover highlights the article Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system by Emmanuel Levy, Hector Garcia-Seisdedos and colleagues. Yeast cells harboring mutation-induced filaments of folded proteins or “agglomerates”. The filaments appear large and disruptive, but surprisingly, Levin et al. reveal they are largely inert and non-toxic, unlike aggregates of misfolded proteins.

@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!

Assay IDs Agglomerates for Intracellular Engineering Protein agglomerates are reversible, so can serve as a regulatory mechanism for intracellular engineering.

Nice to see Tal's work featured in biotech news !

www.genengnews.com/topics/biopr...

GPU-accelerated homology search with MMseqs2 - Nature Methods Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com

Protein aggregate or agglomerate: similar punctate structure with distinct biological profiles | Molecular Systems Biology EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

And cool to see our work featured in the journal! doi.org/10.1038/s443...
Thanks Rui Sun and Yu Liu ☺️

This work has been a long and exciting journey, taking my lab into yeast proteomics and protein functions. All possible thanks to the great work of Tal Levin, Hector Garcia-Seisdedos and @arseniylobov.bsky.social in particular. Also big thanks to our collaborator Ohad Medalia at ZurichU.

The key experiments and findings of the paper are summarized in this graphical abstract:

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social‬ @sciencesunige.bsky.social