Alexey Amunts

Take care, hope it will be ok. Sending best wishes

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Mitochondrial origins of the pressure to sleep
www.nature.com/articles/s41...

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...

Thank you very much for highlighting @beatascienceart.bsky.social illustration of our study on mitoribosome evolution and for explaining the work behind it. It was a wonderful collaboration, and still my favourite cover! @molbioevol.bsky.social
Exciting to see how art and science come together

ACA2025 starter pack, group 12:
@thehedgehoglab.bsky.social
@ellamschmidt.bsky.social
@pdbeurope.bsky.social
@george-tisdale.bsky.social
@acastructuralsci.bsky.social

ACA2025 starter pack, group 11:
@xtalgrrl.bsky.social
@johncolton.bsky.social
@paulhager.bsky.social
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ACA2025 starter pack, group 10:
‪@george-tisdale.bsky.social
@thevillalab.bsky.social
@voslab.org
@arwalker.bsky.social
@james-withrow.bsky.social
@graeme-winter.bsky.social
@shaoliangzheng.bsky.social
@ccdc.cam.ac.uk
‪‪@acastructuralsci.bsky.social

ACA2025 starter pack, group 9:
@alexisrohou.bsky.social
@johnpseudo.bsky.social
@saelicesl.bsky.social
@vssatalkar.bsky.social
‪@ellamschmidt.bsky.social
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‪‪@pdbeurope.bsky.social

ACA2025 starter pack, group 8:
@rcsbpdb.bsky.social
‪@martinpacesa.bsky.social
‪@giuliapalermo.bsky.social
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‪@margotriggi.bsky.social
‪@thehedgehoglab.bsky.social
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ACA2025 starter pack, group 7:
@mirandalynchphd.bsky.social
@sciencemick.bsky.social
@biophyskrys.bsky.social
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@andy-i-nguyen.bsky.social
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‪@jackn.bsky.social

ACA2025 starter pack, group 6:
@dkeedy.bsky.social
‪@kiharalab.bsky.social
‪@kimanius.bsky.social
@htkratochvil.bsky.social
‪@rachael-kretsch.bsky.social
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ACA2025 starter pack, group 5:
@nanigrotjahn.bsky.social
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‪@paulhager.bsky.social
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ACA2025 starter pack, group 4:
@syeffah.bsky.social
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ACA2025 starter pack, group 3:
@maxclabbers.bsky.social
‪@johncolton.bsky.social
@adamcrawshaw.bsky.social
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ACA2025 starter pack, group 2:
‪@xtalgrrl.bsky.social
@dmborek.bsky.social
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ACA2025 starter pack, group 1:
@kaitlynabe.bsky.social
@glycojones.bsky.social
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@lbackman.bsky.social
@cobarnes27.bsky.social
@miguelbaya.bsky.social

ACA 2025 Starter Pack for attendees of the 75th Annual Meeting.
Tried to include everyone, feel free to tag yourself or others missed. Connecting the community at #ACA2025!
@acastructuralsci.bsky.social @rcsbpdb.bsky.social
🔗 go.bsky.app/JAmraSp

Wow, what a surprising discovery and beautifully executed study! The simulations are next-level. Must be a remarkably stable and abundant association if you could pull down with CCD47. Truly impressive work!

Congrats, Ana and team! this is such an important contribution! A major mystery solved through brilliant collaboration. Well done!

In these uncertain times, it's all the more meaningful to support each other, and celebrate resilience, shared purpose and the international collaborative nature of science. Welcome, Vida!

Science builds bridges🇮🇷🤝🇮🇱
Join me in welcoming our new postdoc Vida who brings PhD in plant sciences and will contribute to new bioenergetic studies. Vida is from Tabriz where her family's lives were disrupted by war. Thankfully no casualties, but career delays to her siblings and psychological toll

👍

This work builds on advances by Roman Sobotka, Andi Naschberger when he was a postdoc in my lab, and involved a great collaboration with Xiaobo Li from Westlake University with their outstanding cryo-EM facility, and @bigelowlab.bsky.social in Maine 10/10
Preprint: www.biorxiv.org/content/10.1...

The unique iso-fucoxanthin was modeled into an elongated non-protein density associated with Chl a1277. Its second ring corresponds to a cyclopentane (blue) instead of the canonical epoxy group found in typical fucoxanthin (yellow). This distinct feature identifies it as a novel isoform! 9/10

We also identify previously unreported features in PSI: 1) split subunit PsaA with a new chlorophyll inserted between the split domains, patched by subunit PsaV; 2) a unique iso-fucoxanthin bound to PsaB; 3) extended PsaF with an additional TMH coordinating an extra chlorophyll. 8/10

These structural adaptations include variable elements that mediate contacts with PSI core components, and as a result individual FCP proteins adopt diverse orientations and form specific configurations of functionally coupled chlorophylls for intersubunit energy pathways. 7/10

The antenna system includes five fucoxanthin-chlorophyll proteins (FCPs). Each FCP has evolved a structurally distinct interface to complement the local topology and pigment architecture of its corresponding PSI core docking site. This co-evolution allows to maintain efficient energy transfer 6/10

Our structure offers a mechanistic basis for why SOD monomers are not functionally interchangeable. In the PSI-SOD structure, the binding of SOD1 and SOD2 to PsaD side is pseudosymmetric with SOD1 acting as anchor for the heterodimer, highlighting distinct structural roles for the two subunits. 5/10

Major structural features of PSI involved in this interaction and SOD components are conserved. Thus, the positioning of SOD suggests a mechanism for localized detoxification of reactive oxygen species that is likely be a widespread functional conservation across photosynthetic lineages. 4/10