Clemence 🐀🧠

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity

my favourite house keeping gene

“Pain is indeed a reminder of finitude, a claim on our obedience to something outside the self. It makes us an offer we can’t refuse” - Ellen Wayland-Smith

Well, maybe the children will have to live with two cures instead of 30 cures.