Harrison Stratton

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...

So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity

I realized reading Dear Reader, the Unauthorized Autobiography of Kim Jong Il that some extraordinary men can see mitochondria with their naked eyes just walking around so I’m not surprised.

The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social

8 Sept AI Webinar

Webinar – 8 September
Artificial Intelligence (AI) in Exploratory Human Research
Register: bit.ly/478tBk2
ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns.
#PainEducation

Please consider donating. This is an incredible resource that is the foundation for so much of what we know in biology.

Opinion | America First? Not When It Comes to Your Health.

very well done video on what is happening to basic health research right now all over the US: www.nytimes.com/2025/08/24/o...

Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.

www.biorxiv.org/content/10.1...

The list of the latest published pain papers is out now on PRF! Dr. Qiufu Ma's curated list for August 15-21, 2025 and his choice for Editor's pick can be found here: painresearchforum.org/paper @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.

Really enjoyed going to see the Steeler's preseason game yesterday! The Steeler's played well but in the end lost to Tampa Bay. It was my first time to a Steeler's game and I have to say I enjoyed it. Although it was very hot!

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disea...

This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!

Congrats!! 🙌

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF

This is incredible! Congrats on the manuscript!

Hats off to lead author Tony Lim who drove this project from writing the fellowship application, to establishing new techniques in the lab.

We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA.

Next step, in vivo!

Just posted on Pain Research Forum! Dr. Greg Scherrer's curated list of pain-related papers published August 1-7, 2025 and his choice for Editor's pick. Check it out at painresearchforum.org @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social

It's so beautiful there! How do you build a fake ruin? That's quite intriguing to me.

Check out our new paper in Nature Communications! CRMP5 is a central regulator of pain and DRG hyper-excitability!

What do you think Li et al.’s findings in @natcomms.nature.com of a non-canonical dynorphin receptor does to change our understanding of the endogenous opioid system? bit.ly/3J9hxoA #EditorsPick #PRF

‘Congress has your back’: US senators tell scientists they want to protect NIH budget Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.

‘Congress has your back’: US senators tell scientists they want to protect NIH budget
www.nature.com/articles/d41...

Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF

cool explainer thread ⬇️

Associate or Senior Editor, Nature Neuroscience Title: Associate or Senior Editor, Nature Neuroscience Location(s): New York or Shanghai – Hybrid working model Application Deadline: August 18th About Springer Nature Springer Nature is one of the le...

We're hiring! Nature Neuroscience is hiring an Associate or Senior Editor with experience in cellular and molecular neuroscience, glia, and genomics to work in our New York or Shanghai office. Applications are due August 19.

springernature.wd3.myworkdayjobs.com/en-US/Spring...

Check out this most recent webinar on improving trust in clinical trials. An incredibly important topic!

I can imagine it is quite rough!
Hoping the NIH can come out of this one on top. I know I am grateful to all of you at NIH fighting the good fight to keep science going!

The #nihHEALinitiative is an amazing program
And I hope it can continue! This is the type of science we need more of!