Sohny

Random seeds and brown M&Ms Your first mistake was assuming people actually understand how random numbers work.

A response to all the people who say "if your results depend on your random seed you have bigger problems."
blog.genesmindsmachines.com/p/random-see...

Delighted to announce that our consortium-wide paper demonstrating identification of cancer somatic genome alterations & epigenetic aberrations across traditionally intractable genomic regions (i.e., centromeres & telomeres) by leveraging personalized diploid genome assemblies is now up on bioRxiv.

A telomere-to-telomere map of somatic mutation burden and functional impact in cancer https://www.biorxiv.org/content/10.1101/2025.10.10.681725v1

A complete diploid human genome benchmark for personalized genomics Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

My "Math, Revealed" series is freely available to anyone -- no paywall! -- in the thread below.

This upcoming #WorldEnvironmentDay, we’re highlighting how SMaHT is advancing science in ways that support both human health and sustainability.

By deepening our understanding of somatic mosaicism, SMaHT is helping to drive more precise diagnoses and support a more efficient healthcare system. 🌱🌍

Now published in PNAS: www.pnas.org/doi/10.1073/...

Apologies for getting a bit political on main tonight.

I think this cartoon sums it up.

I freakin love what Liz has been doing.

South Korean parliament votes to impeach acting president Han Duck-soo | CNN South Korea’s parliament voted to impeach prime minister and acting president Han Duck-soo on Friday, less than two weeks after parliament stripped President Yoon Suk Yeol of his powers over his short...

Not over yet and long way to go until we set this straight.
amp.cnn.com/cnn/2024/12/...

I am so sorry for what you are going through Nancy. My prayers are with you and your family.

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Awesome! I feel like there are so many amazing rust-based command-line tools that make life so much easier. I've started replacing tools I used to use with rust-based alternatives (e.g, grep -> rg).

While I appreciate bat for its code viewing capabilities, I find it frustrating when I use it to view binary file which bat doesn’t support. Not to mention the syntax highlighting is lost when piping (gzip -cd foo.bed.gz | bat). But overall bat is so badass I don’t use less anymore

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To Democracy

Here’s to democracy and to resilience.

The president of South Korea has just been impeached.

Why misogyny is at the heart of South Korea's presidential elections Disgruntled young men who resent feminism are the focus of candidates vying to be president.

Just a little reminder that the South Korean president who just declared martial law was elected two years ago on a wave of anti-feminist backlash. Misogyny is routinely part of the authoritarian package.

www.bbc.com/news/world-a...

Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing https://www.biorxiv.org/content/10.1101/2024.11.06.622310v1 Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibe

Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing https://www.biorxiv.org/content/10.1101/2024.11.06.622310v1