volker hovestadt

Drs. Volker Hovestadt and Gabriel Griffin at @danafarber.bsky.social have developed a groundbreaking diagnostic tool, called MARLIN, that could transform the way acute #leukemia is identified and treated.

⚙️ Press release: https://bit.ly/4pUDBEt
🧪 Abstract: https://go.nature.com/48ea16t

03.10.2025 18:18 — 👍 3    🔁 2    💬 0    📌 0

This is figure 1, which shows DNA methylation-based classification of acute leukemia.

A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪

28.09.2025 16:49 — 👍 37    🔁 10    💬 1    📌 1

Diagnostic tool enables rapid leukemia subtype classification Researchers at Dana-Farber Cancer Institute have developed a diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided…

Dana-Farber's MARLIN tool uses AI to classify acute leukemia via DNA methylation in under two hours. It's not just faster; it also resolves diagnostic "blind spots" by identifying new epigenetic classes and cryptic genetic events. #MedAI #MedSky 🧬💻

23.09.2025 15:35 — 👍 5    🔁 2    💬 1    📌 0

Please see our new study on acute leukemia diagnostics using @nanoporetech.com methylation profiling, now out in @natgenet.nature.com ! many thanks to everyone involved !! summary by brilliant med student @til-steinicke.bsky.social below 👇

23.09.2025 01:42 — 👍 14    🔁 2    💬 0    📌 0

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

New ARTICLE now online!

'Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions'

✏️By Mariella Fillbin and colleagues

🔗 www.nature.com/articles/s43...

04.06.2025 10:01 — 👍 3    🔁 2    💬 0    📌 0

FDA-approved FGFR inhibitors show promise against rare and aggressive pediatric brain tumor A study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the Broad Institute of MIT and Harvard has uncovered critical insights into the biology of embryonal tumor with multilayered rosettes (ETMR), a rare and aggressive brain tumor affecting young children.

FDA-approved FGFR inhibitors demonstrate potential as targeted therapy for embryonal tumor with multilayered rosettes, a rare and aggressive pediatric brain cancer driven by unique genetic alterations. doi.org/g9mb9g

26.05.2025 13:32 — 👍 1    🔁 1    💬 0    📌 0

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!

27.05.2025 14:22 — 👍 6    🔁 1    💬 0    📌 0