Eugenio Contreras 's Avatar

Eugenio Contreras

@eugecc.bsky.social

PhD Immunology student #UNAM. Passionate for science and the immune system. Interested in scientific discussion and the creation of space for science diffusion and education. #Mexican #OpenScience #OpenBoxScience @openboxscience.bsky.social

1,748 Followers  |  1,059 Following  |  25 Posts  |  Joined: 15.11.2023  |  2.2859

Latest posts by eugecc.bsky.social on Bluesky

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Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

08.10.2025 17:17 β€” πŸ‘ 22    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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The vaccine we all wear: Skin microbiota can be engineered into topical vaccines Skin microbiota can be engineered into topical vaccines

How basic research at the interface of #immunology and #microbiology leads to potential new #vaccines that could be applied on the skin. Favorite sentence: "We applied bacterial cultures to the heads of mice by gently rubbing their skin with a swab."
www.science.org/doi/full/10....

04.07.2025 16:21 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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πŸŒΏπŸ”¬ Call for Papers: Ecoimmunology Special Collection

Explore how ecological factors shape immune responses in humans & animals - from wild systems to lab models.

πŸ§ͺ Submit your work: bridging ecology + immunology!

πŸ“– https://bit.ly/44N141N

#Ecoimmunology #Immunology

04.07.2025 17:32 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries about peripheral immune tolerance.

BREAKING: Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi win the Nobel Prize in medicine for work on peripheral immune tolerance.

06.10.2025 09:41 β€” πŸ‘ 464    πŸ” 146    πŸ’¬ 12    πŸ“Œ 29
"[Verena Van Der Heide] Finite antigen exposure drives reversible defects in β€˜helpless’ CD8+ T cells
Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible defects of β€˜β€˜helpless’’ memory CD8+ T cells (Immunity 2025) "[Verena Van Der Heide] Finite antigen exposure drives reversible defects in β€˜helpless’ CD8+ T cells

youtu.be/ArQgwaqwpW4
Verena Van Der Heide talk is now on Youtube!
Prolonged but finite antigen presentation promotes reversible defects of β€˜β€˜helpless’’ memory CD8+ T cells. @ ImmunityCP @SinaiImmunol @LCMVlab

03.10.2025 14:31 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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My lab with Dr Miriam Merad @Miriammerad at the national congress of the Mexican Society of Immunology πŸ₯° It was an honour to have the chance to meet such an inspiring leader in immunology

01.10.2025 11:40 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Welcome! You are invited to join a meeting: OBS Immunology Seminar . After registering, you will receive a confirmation email about joining the meeting. Help Wanted: CD4⁺ T Cells as Architects and Rescuers of CD8⁺ T Cell Responses Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible...

OBS Seminar: Neuroimmunology
πŸ‘©πŸ”¬ Sara Trabanelli University of Geneva
"Neural anticipation of virtual infection triggers an immune response"

πŸ—“οΈ Thu 25th September7:00 AM PDT 10:00 AM EDT 2:00 PM GMT 4:00 PM CEST

πŸ‘‡ Registration:
us02web.zoom.us/meeting/regi...

15.09.2025 13:02 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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OBS Immunology Seminar

πŸ‘©β€πŸ”¬ Verena Van Der Heide,
Icahn School of Medicine at Mount Sinai @cp-immunity.bsky.social
πŸ‘©β€πŸ”¬ @valentinavenzin.bsky.social @iannaconelab.bsky.social @unisr.bsky.social @pasteur.fr

πŸ—“οΈ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET

πŸ‘‡
us02web.zoom.us/meeting/regi...

04.09.2025 11:44 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 2

🚫 Update: Our online seminar has been cancelled/postponed. Thanks to everyone who showed interestβ€”we’ll share updates on future sessions here!

03.09.2025 22:05 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Phase 1 of a hypoimmune allogeneic T cell product, CRISPR deleted TRAC, PD1, HLA-A, HLA-B, CIITA, with a CD19-targeting synthetic TCR and antigen receptor in TRAC locus in 5 patients with severe, refractory #lupus nephritis @naturemedicine.bsky.social www.nature.com/articles/s41...

28.08.2025 00:42 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity @cp-immunity.bsky.social @lunduniversity.bsky.social www.cell.com/immunity/ful...

29.08.2025 21:11 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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KIR–HLA Interactions Influences Cetuximab Efficacy in Colorectal Cancer
www.mdpi.com/1422-0067/26...

29.08.2025 16:49 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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πŸ”¬ OBS Seminar

Shaping CD8+ T Cell Response Through Microbiota Metabolites
πŸ—£οΈ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
πŸ—£οΈ@catmphelps.bsky.social @meisellab.bsky.social

πŸ—“οΈ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET

πŸ‘‡ us02web.zoom.us/meeting/regi...

28.08.2025 16:58 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1
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Maternal stress triggers early-life eczema through fetal mast cell programming - Nature Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

Maternal stress triggers early-life eczema through fetal mast cell programming

Nadine Serhan et al. πŸ§ͺ

www.nature.com/articles/s41...

29.08.2025 22:02 β€” πŸ‘ 17    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1
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SΓΊper excited to present my PhD work and meeting the amazing community of the @iuis-online.bsky.social @iuisjuniorcomm.bsky.social. Greatfull of sharing @openboxscience.bsky.social Initiative with the community! Step by step we can make science accesible to everyone in the world!

21.08.2025 12:02 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Next thursday join us for this great discussion!

30.07.2025 10:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer πŸƒβ€β™€οΈπŸ¦ 

11.07.2025 19:46 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Probabilistic migration events drive transient tissue residency of lymphocytes during homeostasis Tissue-resident lymphocytes form a phenotypically and functionally distinct analog to the corresponding circulatory lymphocyte populations. Residential CD8 T cells, in particular, are identified as having prolonged residence in the tissues and key functions in recall responses at tissue-environmental interfaces, although the dwell time in individual tissues has yet to be resolved. Residential CD4 T cells, regulatory T cells, B cells, and NK cells have been demonstrated to share phenotypic properties with residential CD8 T cells, but the migratory kinetics are even more poorly defined. Here we used probabilistic modelling on a large parabiosis dataset, covering multiple time-points and tissues, to calculate migration kinetics and dwell times of multiple lymphocyte subsets across a diverse set of tissues. Markov chain modelling identified distinct cell type-specific and tissue-specific residency patterns. The liver and gut were prone to prolonged residency compared to other tissue types, and a hierarchy of residency was observed with CD8 T cells and NK cells demonstrating longer residency than CD4 conventional T cells and regulatory T cells, which in turn resided in tissues longer than B cells. With few exceptions, however, average residency was at least an order of magnitude shorter than the life-span of the mouse, indicating a more dynamic form of steady-state tissue residency than usually assumed. Together these data provide a comprehensive model of a pan-tissue shared program in lymphocyte tissue residence, as well as identifying cell type- and organ-specific modification of the migratory kinetics. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, https://ror.org/029chgv08, 222442/Z/21/Z European Research Council, TissueTreg

I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. 🧡1/10

www.biorxiv.org/content/10.1...

09.07.2025 08:17 β€” πŸ‘ 66    πŸ” 22    πŸ’¬ 1    πŸ“Œ 3
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Utility of transgenic hematopoietic stem cell to generate a self-renewing source of tumor-specific cellular immunotherapy in human participants @natcomms.nature.com
www.nature.com/articles/s41...

02.07.2025 19:39 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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πŸ“£Call out to #bcell enthusiasts!

#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.

Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.

@yefis-immunology.bsky.social

25.06.2025 10:43 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Other groups have shown that a fraction of intratumoral Tregs are actually pTregs, derived from the conversion of Th1 cells into pTregs mediated by TGF-Ξ². A lot of research needed to solve the contribution of TGFb on nTreg vs pTreg in tumor promotion. rupress.org/jem/article/...

23.06.2025 14:33 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Using an elegant approach, it was demonstrated that a big majority of intratumoral Treg nTreg instead of pTreg. This is critical, as we normally think that TGF-b coming from the TME is promoting local Treg differentiation!🧐

www.science.org/doi/10.1126/...

23.06.2025 14:33 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis
www.biorxiv.org/content/10.1...

13.06.2025 03:29 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Butyrate enhances CD56bright NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility
www.nature.com/articles/s41...

13.06.2025 04:23 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

Perspective @natrevimmunol.nature.com @lilykeane.bsky.social
A role for microglia in mediating the microbiota–gut–brain axis
www.nature.com/articles/s41...

13.06.2025 04:21 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer @cp-cellstemcell.bsky.social
www.cell.com/cell-stem-ce...

13.06.2025 04:40 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

πŸ§¬πŸ”¬ "When the skin speaks, the immune system listens β€” even miles away" πŸ”¬πŸ§¬
Join us next Thursday!

02.06.2025 21:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Cada vez mΓ‘s cerca. Nos vemos en el Congreso Nacional de InmunologΓ­a en Chihuahua! @sminmunologia.bsky.social
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y mΓ‘s...

30.05.2025 17:59 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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πŸ”¬ OBS Immunology Seminar

πŸ—£οΈ @mariemradhouani.bsky.social l @starkllab.bsky.social lab.bsky.social @meduniwien.ac.at @cemm-vienna.bsky.social
πŸ—£οΈDaniel A. Waizman Andrew Wang Lab
@yalemedicine.bsky.social

πŸ—“οΈ Thu, June 5th, 11 pm ET
πŸ‘‡
us02web.zoom.us/meeting/regi...

29.05.2025 13:55 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 2
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The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...

28.05.2025 17:54 β€” πŸ‘ 12    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

@eugecc is following 20 prominent accounts