What on earth justifies giving so much money to one single person? With an average Western income, you would have to work for tens of millions of years to earn that much. If such a person had started working when the dinosaurs became extinct, they would have so much money by now. Think about it.
07.11.2025 10:16 — 👍 1 🔁 0 💬 0 📌 0
Morgen alle nach Berlin!
#Stadtbild
#CDUschadetDeutschland
#AFDVerbotJetzt
18.10.2025 19:43 — 👍 239 🔁 97 💬 4 📌 7
Dass wir im heutigen Stadtbild so viele Stolpersteine haben, liegt übrigens daran, dass sich mal eine Regierung an bestimmten Menschen im deutschen Stadtbild störte.
18.10.2025 05:38 — 👍 3406 🔁 1188 💬 40 📌 29
Vor ziemlich genau 8 Jahren hat Jörg Meuthen, ehem. Vorsitzender der AfD, gesagt, er sehe in den Innenstädten "noch vereinzelt Deutsche". Die Vorsitzende der CDU, Angela Merkel, hat ihm umgehend widersprochen. Friedrich Merz hat heute die Sprache und Position der AfD übernommen.
16.10.2025 13:27 — 👍 3554 🔁 1206 💬 90 📌 65
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
09.10.2025 09:01 — 👍 163 🔁 40 💬 9 📌 3
Oh no, I‘m sorry!
05.10.2025 19:42 — 👍 0 🔁 0 💬 0 📌 0
12yo daughter is heartbroken because after watching Titanic recently she found out that this is how Leonardo DiCaprio looks today
03.10.2025 14:07 — 👍 3 🔁 0 💬 0 📌 0
@janakroll.bsky.social on stage receiving the poster award at #BiomembraneDays25
cool story and well deserved 🥳
01.10.2025 15:33 — 👍 2 🔁 0 💬 1 📌 0
Stunning talk!
01.10.2025 15:06 — 👍 1 🔁 0 💬 0 📌 0
Helge @ewerslab.bsky.social knows not only how to organize conferences (#BiomembraneDays25) but also how septins organize. Exceptional imaging #ExpansionMicroscopy of cytokinesis
01.10.2025 13:06 — 👍 16 🔁 3 💬 0 📌 0
Alf Honigman clarified condensation and receptor segregation at cell junctions at the #BiomembraneDays25
01.10.2025 10:15 — 👍 4 🔁 1 💬 0 📌 0
Kandice @leventallab.bsky.social showed a great construct for resolving membrane organization around transmembrane domains
#BiomembraneDays25
01.10.2025 10:18 — 👍 15 🔁 2 💬 0 📌 0
Sketches of six stages of cytokinetic development of the intercellular bridge are illustrated with exmaple U-ExM fluorescence microscopy images. Septin2-GFP shown in green. Tubulin shown in magenta. A shortened workflow illustrates the image alignment and averaging process to generate average 2D reconstructions of cytokinetic stages.
It is out! 🦚 I recorded hundreds of #ExM 🔬images of cytokinetic bridges and averaged them into 6 stages. How? With help from our fantastic collaborators @zacsimile.bsky.social and @jonasries.bsky.social in Vienna 😇. Check out the full atlas here: doi.org/10.5281/zenodo.17232370
30.09.2025 16:24 — 👍 32 🔁 10 💬 1 📌 1
Evidence is growing for RhoA regulating septins. Cool optogenetics-driven work by @pwoakes.bsky.social and @myosincity.bsky.social
30.09.2025 15:26 — 👍 0 🔁 0 💬 0 📌 0
The bacteria bots are so cool! Microcyborgs 🦠🤖
30.09.2025 14:37 — 👍 0 🔁 0 💬 0 📌 0
Really impressive work!
30.09.2025 09:41 — 👍 1 🔁 0 💬 0 📌 0
Great talk from @sciezgin.bsky.social (aka komsu) at the #BiomembraneDays25 on correlating biophysical properties like packing and hydration to biomatkers for disease
29.09.2025 09:38 — 👍 13 🔁 3 💬 0 📌 0
Really impressive work on the regulation of condensates in so many cellular processes!
29.09.2025 09:50 — 👍 2 🔁 0 💬 0 📌 0
🎉 Finally: tomorrow Sept 29 we open BIOMEMBRANE DAYS 2025 in Berlin: 3 days packed with exciting science on membranes!
Looking forward to an amazing program of invited & contributed talks, posters & lively discussions.
📍 events.mpikg.mpg.de/event/15/
@ewerslab.bsky.social @mpici.bsky.social
28.09.2025 16:37 — 👍 33 🔁 7 💬 2 📌 2
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
28.09.2025 14:15 — 👍 68 🔁 26 💬 2 📌 4
it’s me! and the work of @pm-mueller.bsky.social Meret Fischer, Chethana, Ria Thielhorn, Mengfei Gao, Michael Dyhr and, most prominently Nadja Hümpfer
28.09.2025 08:54 — 👍 8 🔁 2 💬 1 📌 0
Getting ready for the #BiomembraneDays25 events.mpikg.mpg.de/event/15/
26.09.2025 09:51 — 👍 6 🔁 1 💬 0 📌 0
We should have more concerts at the Freie Universität again!
23.07.2025 18:22 — 👍 1 🔁 0 💬 0 📌 0
Protestierende mit Schildern
Etwa 3000 Personen protestieren gerade vor den Senatsverwaltung für Wissenschaft gegen die Sparmaßnahmen des Landes Berlin. Toll, dass wir so viele sind! 👏
Motto: Hochschulen sind #unkürzbar 💪
ℹ️ www.fu-berlin.de/sites/hausha...
14.07.2025 07:50 — 👍 104 🔁 31 💬 0 📌 1
Ich habe am 19. November Geburtstag. Menschen, die am 19. November Geburtstag haben, sind für weniger als 1% der CO2-Emissionen verantwortlich. Wieso sollen wir etwas ändern? Das bringt doch überhaupt nichts. Lasst uns am 19. November Geborene doch bitte mit eurer Klimapolitik in Ruhe!
09.07.2025 20:27 — 👍 1605 🔁 224 💬 54 📌 7
Check out how we became "accidental immunologists"! Wonderful 🧵 from Carmen who has led this project for the past 4 years! Thanks to Xiaolei Su (Yale) for scientific support and @hfspo.bsky.social for the financial support and for allowing us to step out of our comfort zone!
09.07.2025 12:46 — 👍 15 🔁 5 💬 1 📌 0
T cell protrusions enable fast, localised initiation of CAR signalling
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and immune signalling initiation. To investigate how membrane protrusions initiate and contribute to signalling, from the first cell-cell contact to immunological synapse formation, we performed dynamic imaging experiments of endogenously tagged signalling proteins in T cells. To quantitatively capture the early dynamics of cell-cell interactions, we employed HER2‑CAR-expressing T cells targeting HER2⁺ breast cancer cells. By harnessing live-cell imaging and super-resolution stimulated emission depletion (STED) microscopy we were able to capture topological membrane changes and their correlation with mesoscale protein rearrangements over time. Our findings indicate that, prior to activation, key molecular players in T cell activation, including the kinase Lck, the phosphatase CD45 and the adaptor LAT, as well as the exogenously expressed CAR, lack any enrichment in actin-rich protrusions. However, upon initial contact of the T cell with the target cell, a dynamic and fast rearrangement of the surface receptors, phosphatases, and kinases occurs within the protrusions, ensuring a rapid and effective initiation of the immune signalling cascade. The rapid clustering of the HER2-CAR occurs preferentially within protrusions rather than flat membrane regions and is accompanied by enhanced recruitment of the kinase ZAP-70 and LAT. While the localisation of the kinase Lck remained unchanged, protrusion-cell contacts trigger a pronounced exclusion of the phosphatase CD45, an effect observed both with and without the cytosolic signalling domain of the CAR. Overall, the signalling machinery rearranged more rapidly and efficiently at contacts mediated by protrusive structures compared to non-protrusive regions. Together, our data provide a quantitative framework illustrating how signalling proteins are dynamically reorganised to facilitate CAR-mediated activation within these specialised structures. ### Competing Interest Statement The authors have declared no competing interest.
Check out our new preprint on the role of T cell actin-rich protrusion in CAR signalling initiation.
Spoiler alert: Protrusions do it better
www.biorxiv.org/content/10.1...
09.07.2025 12:50 — 👍 29 🔁 5 💬 3 📌 3
Fehlende Buchstaben waren ein Symbol. Fehlende Mittel sind Realität. (Grafik, Freie Universität Berlin)
🫴 Das E ist zurück. Die Euros nicht.❌ 💰
Eine Woche haben wir bewusst auf den Buchstaben E verzichtet – als Symbol für das, was fehlt, wenn an der Substanz gespart wird.
Wir bleiben dran: Wie die #FUBerlin auf die #Haushaltskürzungen des Berliner Senats reagiert: www.fu-berlin.de/sites/hausha...
30.06.2025 07:50 — 👍 49 🔁 12 💬 2 📌 0
A platform by EMBO that provides independent peer review before journal submission for Refereed Preprints.
Personal Account
Founder: The Distributed AI Research Institute @dairinstitute.bsky.social.
Author: The View from Somewhere, a memoir & manifesto arguing for a technological future that serves our communities (to be published by One Signal / Atria
I write about the strange side of AI at aiweirdness.com
Also a laser scientist.
She/her. Colorado, USA
Founder & PI @aial.ie. Assistant Professor of AI, School of Computer Science & Statistics, @tcddublin.bsky.social
AI accountability, AI audits & evaluation, critical data studies. Cognitive scientist by training. Ethiopian in Ireland. She/her
Professor of Computational Cognitive Science | @AI_Radboud | @Iris@scholar.social on 🦣 | http://cognitionandintractability.com | she/they 🏳️🌈
https://olivia.science
assistant professor of computational cognitive science · she/they · cypriot/kıbrıslı/κυπραία · σὺν Ἀθηνᾷ καὶ χεῖρα κίνει
Research and data to make progress against the world’s largest problems. Based out of Oxford University (@ox.ac.uk), founded by @maxroser.bsky.social.
Systems Pharmacology and Biology Lab at @DepBiomedicine, University of Basel, Switzerland.
We exploit metabolic weaknesses for therapeutic applications.
www.zampierilab.org
Psychologist/Journalist/Media Prof. @HAW_hamburg, Disinfo Researcher, SPIEGEL-Column: http://tinyurl.com/DerRationalist. New book http://tinyurl.com/weltverbrenner. Blocks trolls
MdEP, Delegationsleiter der deutschen Grünen im Europaparlament;
erik-marquardt.eu
Autorin. Politik & Internet. Bücher: Die Daten, die ich rief, Fake Facts, True Facts, Gefährlicher Glaube Podcast: www.denkangebot.org Mastodon: http://chaos.social/@kattascha
Dr. med. Cihan Çelik, Facharzt für Innere Medizin und Pneumologie, Sektionsleiter Pneumologie am Klinikum Darmstadt. FAS Interviewserie "Wie ist die Lage, Herr Doktor" seit 2020. Medizin, Wissenschaft, Humanismus.
Blog about the human side of #science, by Brooke Morriswood (formerly Cam Biochem, CIMR,MRC-LMB,Yale, MFPL, UniWue, now #MedComms). Commentary, silliness, & how-to guides for improving young scientists’ soft skills.
https://totalinternalreflectionblog.com
Hauptstadtbüro DER SPIEGEL - AfD, Innere Sicherheit und sexualisierte Gewalt - Buch „Die Unsichtbaren“ mit @mb-journalist.bsky.social - Threema: 78XAU7T3
„Die Demokratie ist bedroht, wenn die Menschen nicht mehr zwischen Wahrheit und Lüge unterscheiden können.“
Niemand hat Anspruch darauf, dass ich mich nach seinen Wünschen verhalte 🤷🏻♀️
Journalistin, Juristin, Jongleurin mit den Bällen, die das Leben Dir so zuwirft.
PhD student at Karolinska Institutet and Scilifelab | Cell physics
https://www.csi-nano.org/
Bio enthusiast
PhD candidate @ TU Dresden
Postdoctoral Research Fellow at University of Exeter (UK)
Scientific Editor at BBRC (Elsevier).
