Timothée Bruel

New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.

Read the associated research article here: www.nature.com/articles/s41...

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor @natmicrobiol.nature.com Microbiol
www.nature.com/articles/s41...

Congrats to @summabibby.bsky.social @naphakm.bsky.social Daniel Watterson et al. here at SCMB on the first high-res cryo-EM structures of yellow fever virus! Striking vaccine vs virulent particle differences and a single R380 residue shaping antigenicity & neutralisation. doi.org/10.1038/s414...

HIV infection of CD4 T cells drives KLF2 and p53 signaling, which downregulate MYC and proliferation pathways, resulting in proviral transcriptional silencing to enhance latent reservoir formation @natmicrobiol.nature.com @saba-valadkhan.bsky.social
www.nature.com/articles/s41...

« Chromatin profiling revealed that IRF1 and IRF2 occupy the same ISG regulatory sites, but as a weaker transcriptional activator, IRF2 limited ISG transcription by IRF1. »

How to repress with an activator. What a stunning study. Reaching that level of mechanistic details is very inspiring!

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy https://www.biorxiv.org/content/10.1101/2025.09.22.677905v1

Establishment of reverse genetics systems for Colorado tick fever virus. Remind me never to complain about monopartite reverse genetics systems.
journals.plos.org/plospathogen...

LRP8 is a receptor for tick-borne encephalitis virus - Nature LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

Big news in tick-borne flaviviruses:

www.nature.com/articles/s41...

A transatlantic joint lab model for interdisciplinary research - Nature Microbiology A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current...

#Comment

A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.

#MicroSky #AcademicChatter

www.nature.com/articles/s41...

An immune-competent lung-on-a-chip for modelling the human severe influenza infection response @natbiomedeng.nature.com @vanderbilt.edu
www.nature.com/articles/s41...

Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations Non-neutralizing antibodies to influenza A are broadly protective and resist viral escape, offering strong therapeutic potential.

Non-neutralizing antibodies to influenza A matrix-protein-2-ectodomain are broadly effective therapeutics and resistant to viral escape mutations www.science.org/doi/10.1126/...

Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease - Nature Microbiology Salivary virome profiling revealed distinct virome profiles in Sjögren’s disease and a role for Vientovirus in triggering autoimmunity through molecular mimicry.

Vientovirus capsid protein mimics autoantigens and contributes to autoimmunity in Sjögren’s disease

www.nature.com/articles/s41...

Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity. Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...

Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity!
www.biorxiv.org/content/10.1101/2025.09.03.673949v1

Exclusive: retraction-prone editors identified at megajournal PLoS ONE Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.

These editors handled only 1.3% of all articles published by the journal from 2006 to 2023, but the papers they accepted accounted for more than 30% of the 702 retractions that Plos One issued by early 2024.

B and T cell receptor repertoires as well as nasal and systemic immune responses correlate with length of viral shedding after influenza challenge
www.science.org/doi/10.1126/...

@vijayrathinam.bsky.social @vinnieviruses.bsky.social ‪@raflynn5.bsky.social‬ discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...

Book Cover for Mastering Machine Learning: From Basics to Advanced. Even the title doesn't sound human does it?

THREAD
Not all attention is good attention

In July 2025 the book "Mastering Machine Learning: From Basics to Advanced" made headlines after it was discovered that a large part of its citations were made up or substantively incorrect.

Suboptimal.

www.inkl.com/news/bo...



1/9

Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.

New in @science.org
We built a safe, atomic-resolution version of the Powassan virus—a deadly tick-borne #flavivirus with no vaccine.
✅ First structure ever
✅ Safe to handle (BSL-2)
✅ Platform for vaccines & antivirals

Let me show you 🧵 (1/5)

Link: www.science.org/doi/10.1126/...

Feline infectious peritonitis epizootic caused by a recombinant coronavirus

www.nature.com/articles/s41...

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics - Nature The molecular mechanisms of cell entry for the recently identified highly pathogenic feline coronavirus FCoV-23 are characterized in detail.

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics

www.nature.com/articles/s41...

A thread- resolving the Omicron Paradox.

Still playing with PDB files and my pen plotter 👌

Here is a direct link:

blnkhz.github.io/plotter-tools/

Huge credit to BlnKhz!

Playing with a PDB structure of SARS-CoV-2 (7DF3), the amazing blnkhz.github.io tool, and an iDraw pen plotter 😀

EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" Trois de nos plus grands scientifiques, Yasmine Belkaid, Bana Jabri et Alain Puisieux, prennent la parole pour appeler à des réponses courageuses des pouvoirs publics face aux attaques contre la recherche, aux Etats-Unis, mais aussi de ce côté de l’Atlantique.

🔴 EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" ⬇️

✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler

#Medsky 🧪 #IDsky #immunosky #publichealth The spike protein of many #sarbecoviruses binds to ACE2 receptor & facilitates viral entry. The diversification of 🦠 spike gene & the mammalian ACE2 gene suggests that s.viruses & their hosts have co-evolved .Another excellent study frim Kei Sato San et al👇🏿

Illustration of 5 birthday candles, only 4 are burning. The text reads: "Every year, 4.8 MILLION children do not make it to their fifth birthday"

One of life’s greatest tragedies is losing a child.

And yet, 1 child under 5 dies somewhere in the world every 18 seconds - mostly from preventable causes like

💔 Birth complications
💔 Pneumonia
💔 Diarrhoea
💔 Malaria

This amounts to 4.8 MILLION deaths each year.

NEW report: bit.ly/4kTTBUV

There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.

OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity Innate immune signaling pathways are traditionally considered to be intracellular. Huai et al. show that the RNA-sensing OAS-RNase L pathway can initiate in one cell and complete in another cell throu...

#TheMoreTheMerrier! Wu, Yan &co show @cp-immunity.bsky.social that antiviral OAS alerts neighboring cells by producing 2-5A which via gap junctions or exporter/importer activates RNaseL, protecting against infection or tumor growth! #ScienceSavesLives dlvr.it/TJB0nT