Hanna Julienne

Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal variants from genetic association data (individual-level or summary data). mvSuSiE learns patterns of shared gen...

🧬👩‍🏫 Today, in our Journal Club, we discussed this preprint about multi-trait GWAS finemapping by Matthew Stephens’ Lab

Yuxin Zou et al. Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits Asthma is a complex and heterogeneous disease with a large spectrum of clinical and biological expressions reflecting the multiple underlying pathophysiologic mechanisms. It can be divided into subtyp...

A new collaborative work with our colleagues from HealthFex! Unraveling shared genetics across asthma subtypes and 81 asthma-related traits - www.jacionline.org/article/S009...

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits Asthma presents clinical and biological heterogeneity.We sought to better understand asthma heterogeneity by investigating the shared genetics between…

This highlight the heterogeneity encompassed in the asthma umbrella diagnosis, and the molecular differences between adult-onset and childhood-onset asthma ! More detail in the full paper 📑

www.sciencedirect.com/science/arti...

👧Childhood-onset asthma variants were overwhelmingly shared with:

🔸IgE levels,
🔸Eosinophil counts

(MIXeR analysis)

🧑 Adult-onset asthma showed stronger genetic links to:

🔸Higher BMI
🔸Reduced lung capacity

compared to childhood-onset asthma

In this study, we curated 254 GWAS summary statistics to explore the shared genetic architecture between:
✔ Asthma (overall)
✔ Asthma subtypes (severity, age-of-onset)
✔ 81 related traits (spirometry, blood counts, interleukins, and more)

🧬 New multi-trait genetic paper on asthma heterogeneity from Emmanuelle Bouzigon's lab and lead by Raphaël Vernet in the Journal of Allergy and Clinical Immunology

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits

🔗 doi.org/10.1016/j.ja...

🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...

Highlights below!

A recent piece from my team describing the plateauing of #PRS accuracy with large sample size #GWAS

The International Genetic Epidemiology Society (IGES) is now on Bluesky! 👋🧬

We are the only international scientific society devoted to promoting the study of genetic epidemiology and statistical genetics. Follow along for the latest from IGES! #genetics #epidemiology #statistics #science #IGES

Programme MD-PhD logo_ppu_md_phd.png

🔬👨‍⚕️Face aux défis sanitaires croissants, infections émergentes, résistance aux antibiotiques, climat... l’Institut Pasteur lance son programme MD-PhD pour former les médecins-chercheur·se·s de demain !

Stages, thèses précoces ou tardives : un parcours flexible selon votre profil.

En savoir plus 👇

Jusqu'à dimanche soir, @mediapart.fr est gratuit. Enjoy 💫

Pentagon abruptly ends all funding for social science research More than 90 studies on threats such as climate change, extremism, and disinformation are halted

The U.S. Department of Defense (DOD) is ending all of its funding for social science research, stopping 91 ongoing studies related to threats such as climate change, extremism, and disinformation.

www.science.org/content/arti...

Alternate stream in case the Twitch audio wasn't working for you! bsky.app/profile/stan...

Incroyable exemple de @valmasdel.bsky.social sur la censure du monde scientifique en cours aux Etats-Unis: sa collègue du GIEC, "a été interdite de se rendre à la dernière session plénière du GIEC, l'équipe qui l'aide a été démantelée, elle a interdiction de parler à la presse"..

#StandUpForScience

📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !

French researchers demonstrating under the sun in Paris

French researchers demonstrating under the sun in Paris near La Sorbonne

French researchers demonstrating under the sun in Paris in front of jussieu

French researchers demonstrating under the sun in Paris #standupforscience @pasteur.fr @inserm.fr

🔬A un moment où la #science fait l’objet de mises en causes préoccupantes aux Etats-Unis 🇺🇸 (censure, arrêts de grands programmes et annonce de licenciements massifs dans la recherche publique), INRAE soutient le mouvement #StandUpForScience ✊
(1/2)

The march continue with a lot of people @standupforscience.bsky.social

Stand up for science, Paris

We are here in Paris numerous and under the sun ☀️ to #standupforscience 🧫🧪👩‍🔬🔭

Tous les évènements | Stand Up For Science France Pour saisir un nouvel évènement, utiliser le bouton (+) sur la carte. L’évènement sera publié après validation.

#standeup4science #esr

Le rassemblement à Paris est à 13h30 à Jussieu.

à Lyon : Rassemblement à 16h Place des Terreaux.

La liste des initiatives est en ligne ici :

standupforscience.fr/tous-les-eve...

Map of Stand Up for Science events, with official SUFS events in Red and solidarity events in Blue

WHERE WILL YOU BE ON MARCH 7TH!?

Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!

#standupforscience2025

🚨 10 Days Until Stand Up for Science, and some HUGE NEWS! - Take Action With Us! 🚨

We’re excited to announce 32 official Stand Up for Science events happening across the country on March 7th!

🧵⬇️

Le 7 mars, mobilisons-nous pour les sciences ! 🔬✊ En écho à Stand Up For Science (@standupforscience.bsky.social) et face aux menaces contre les institutions scientifiques, des actions auront lieu dans chaque ville universitaire de France. Infos & inscriptions 👉 standupforscience.fr

The Democrats on the House Science Committee have set up a website to collect stories from fired federal employees, anonymously if desired. Please amplify. (This helps the lawyers establish standing for bringing legal cases against the administration!)

democrats-science.house.gov/sciencefirings

🧠🔎 Why do we fall for fake news?

Join philosophers & neuroscientists to explore how our brains shape our perception of truth.

📅 March 15, 2 PM | Hall Duclaux | Institut Pasteur

🎟 Free, registration required : www.eventbrite.fr/e/comprendre...

Mes cours de cette année porteront sur « Inné ou acquis ? L’impact de la génétique sur la diversité biologique et les maladies », et se tiendront tous les vendredis, du 7 mars au 4 avril, au Collège de France.
@collegedefrance.bsky.social
@pasteur.fr

Women scientists: inspiring faces of research at the Institut Pasteur The International Day of Women and Girls in Science 2025 is an opportunity to shine the spotlight on committed and talented women researchers. In addition to their scientific work, these Institut Past...

👩‍🔬 On this #WomenInScience Day 2025, we celebrate the inspiring female scientists at Institut Pasteur! More than researchers, they make science accessible to all. 🌍✨

Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...

Let’s continue to amplify their voices 🚀

For someone who has been closely watching the @nextflow.io official documentation for almost three years now, I must say that it has improved tremendously! 🤩

This highlights our commitment to delivering high-quality documentation. When one opens a Pull Request on GitHub to make some code changes in