Arthur Frouin

‘Google for DNA’ brings order to biology’s big data MetaGraph compresses vast data archives into a search engine for scientists, opening up new frontiers of biological discovery.

Ca n'est pas si souvent, un article publié dans Nature met ma communauté à l'honneur (la bioinformatique des séquences). Je vous raconte ?
www.nature.com/articles/d41...

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

A comic strip in four panels: 1. A bird's-eye view of a giant amphora the size of a building with closed eyes and a closed mouth engraved on it. Using scaffolding, a community of wizards climbed up and are throwing all their books into it, to fill its content. > Wizards: All our grimoires for the Amphora of Great Intelligence! 2. A ground level view at the bottom of the giant amphora. This time, the wizards bring tree trunks, cut down nearby trees, and throw them into a large fire to boil the giant amphora. > Wizards: All our forests for the Amphora of Great Intelligence! 3. A gathering of all the wizards below the imposing amphora which has now opened its glowing eyes and mouth slightly. The crowd of wizards at its feet applauds: > Wizards: Amphora of Great Intelligence, our world is dying, share your knowledge with us! 4. Same shot, as the amphora responds with joyful and amused eyes. The wizards are confused by the answer... > Artificial Intelligence: According to geologists, you should eat at least one small rock per day. > Wizards: ... ... ...

The Amphora of Great Intelligence (AGI)

#webcomic #krita #miniFantasyTheater

Le montant final officiel de ce #ZEVENT2025 s'élève donc à 16 179 096€ au profit des soignants et des patients.

Merci à tous pour votre énergie et votre générosité. 💚

Mathematical modelling for biologists - Modelling concepts in biological research Mathematical modelling for biologists - Modelling concepts in biological research

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...

Including both molecular and epidemiological examples

Microbial metal physiology: ions to ecosystems Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals

rdcu.be/eycU2

Capture d'écran de Framaspace. On y voit : - En fond, un document Markdown ouvert - Au premier plan, le logiciel de synchronisation de Nextcloud, indiquant quels dossiers sont synchronisés sur l'ordinateur et les dernières activités de synchronisation.

Avec #Framaspace, vos documents, agendas et contacts peuvent être entièrement synchronisés sur votre ordinateur ou smartphone ! 🔄

➡️ https://framaspace.org

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

Postdoc (London, UK)
Research scientist to lead virus evolution and bioinformatic data analysis for wastewater surveillance of pandemic pathogens.
at Imperial College London
More details: http://iddjobs.org/jobs/2341

My biggest, loudest job application advice:

WHY do you want this job? This SPECIFIC job? What about it interests you? What do you think of it? What can you bring to it?

I know this sounds obvious but a generic cover letter isn't doing you favours - really. *Show me you know the job!*

1/7

🌟 Exciting news! We’re launching three fully-funded postdoc positions for "New Horizons for Synthetic Phages”

Join us in tackling antimicrobial resistance with cutting-edge synthetic biology + AI bioinformatics. Based at Flinders Uni in vibrant Adelaide.

👇 Read on for details!
#Phage

Looks very cool ! Just a quick comment: the legend of figure S3 is very hard to read for color blind ppl, in particular the first and last item.

Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA) Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...

🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec

This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n

www.biorxiv.org/content/10.1...

Scientists and engineers could:

Sequence the human genome
Put a man on the moon
Invent the internet
Solve protein folding problem
Decipher the complex immune system.

But fail to design a poster session in which you can actually hear the presenter.
In nearly every meeting out there.

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

🧵 Do you have R packages that make your workflow smoother or help you avoid problems you used to face all the time? I’ve collected a few that solved issues that used to trip me up 👇

Antimicrobial resistance: a concise update Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive...

The overview of AMR that you always wanted (someone else to write) - amazing!

Truly brilliant paper with great figures! @lancetmicrobe.bsky.social

www.thelancet.com/journals/lan...

Les signataires de la pétition contre la loi Dupont seront bientôt plus nombreux que les électeurs et électrices du parti de François Bayrou.

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before s...

The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study - The Lancet Microbe www.thelancet.com/journals/lan...

Any favorite papers using or review papers on applying modern machine learning methods to human GWAS?

Coalescence and Translation: A Language Model for Population Genetics Probabilistic models such as the sequentially Markovian coalescent (SMC) have long provided a powerful framework for population genetic inference, enabling reconstruction of demographic history and an...

Cool new paper on pop gen and machine learning:

www.biorxiv.org/content/10.1...

What determines who a phage can infect?

We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.

👇 A thread!

Come and work with me and use the 53,897 samples of M. tuberculosis we have collated to help tackle this important disease!

We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis.

Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July

bit.ly/4ndKOhF

PanVA: a visual analytics tool for pangenomic variant analysis https://www.biorxiv.org/content/10.1101/2025.06.23.661080v1

Genomics of host–microbiome interactions in humans Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...

Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field.
rdcu.be/epoRR

@blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.

Social card for vacancy which reads "Research Scientist. Develop pipelines for metagenomic and amplicon sequencing data to understand the role of prokaryotes in mitigating greenhouse gas emissions. Salary: £36,720 to £42,000. Contract length: 9 months. Apply by 8 July 2025".

Do you have an interest in soil microbiology and biogeochemical cycling, and statistics/programming skills (either R, python, Perl, C++, or equivalent)?

Check our current vacancy ⤵️

💷 £36,720 to £42,000 per annum
🗓️ Apply by 08 July 2025
➡️https://buff.ly/BSB0Qfh

This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Just like buses, here is a third role we are advertising for!

Come and help @philipwfowler.bsky.social use the large TB datasets we hold to help the OxCoD4TB consortium develop new therapeutics for tuberculosis.

Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July

bit.ly/4ndKOhF

Wake up, losers - new giant rat testomcelles have just dissilced, and they have truly got their dck out.

If you go to Africa, here are some localities you should avoid:

GUTNED
CLINE LSOGLE
NAOZAWA V
GROSGRIVER