Gregor lab

🚀Open PhD position!
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd

Our paper on the anti-cancer effects of the first-in-class plectin inhibitor plecstatin is out in @MolOncology! Great work by @OutlaZuzana & @Kosla_Jan. Collaborations with @Selma_OsMyers (@MedUniWien), Sam Meier (@univienna) & Lukas Frick (@UZH). Check at pubmed.ncbi.nlm.nih.gov/41467448/

It’s been an eventful year for all of us! Our Christmas party was a great reminder of the team spirit behind the science & we’re excited to take on the challenges of 2026. Merry Christmas & Happy New Year from the Laboratory of Integrative Biology!

At #WMS2025 in Vienna? Check out our PhD student Vera Getmanchuk-Zaporoshchenko’s poster on phenotyping a preclinical model of plectin-related LGMD. #LGMD #MuscularDystrophy"

Huge congrats to our PhD student, Piyush Bisht, for presenting his work on Flipper-TR probe applied to Circulating Tumor Cells at #Czechbioimaging's Imaging Principles of Life 2025 conference in Brno! He had amazing discussions and valuable feedback. Way to go, Piyush!" @imgprague.bsky.social

Unikátní výzkum českých vědců. Testují metodu, která by mohla zastavit šíření rakoviny | TN.cz Čeští vědci testují novou metodu, která by mohla zpomalit, nebo dokonce zastavit šíření rakoviny. Pomocí unikátního postupu dokážou ovlivňovat chování živých nádorových buněk. Výzkum probíhá zatím v l...

tn.nova.cz/zpravodajstv...

Two hours of tough work to make 2 minutes of science sparkle ✨ Today we helped popularize our #magnetogenetics manuscript by Gemperle Jakub for NUVR_CZ. Tune in to TV NOVA evening news!

“Cellfie: A triple-stained portrait of HeLa’s senescence” by Spoorthi Suresh Hiremath (@imgprague.bsky.social; ‪@gregorlab.bsky.social‬) has won the Prague @eurobioimaging.bsky.social Node Picture of the Month. Congrats Spoorthi!

Our paper is getting 🔥attention on Instagram👍
www.instagram.com/reel/DL3O9AA...

Congratulations to Jakub Gemperle for driving this research from start to finish!

Gamechanger for vesicle Control! We present an approach to remotely control endosomal distribution in living cells (even in #3Dmatrix) with high precision.

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.

"It's official 🎉: Our remote magnetic control of #endosomes, driving invasive protrusions in living cells, has landed in #ScienceAdvances! #Magnetogenetics meets #Rabs! The journey was wild, but it works! 🔥 www.science.org/doi/full/10....
@imgprague.bsky.social #3Dmatrix #CellBiology
@science.org

Huge congratulations to our PhD student Srikant Ojha for winning the Microscopic Picture of the Year 2024/2025 award! Well deserved!

30th Cytoskeletal Club was opened in Liblice on Monday, 28 April. The first day is complete - great keynote by Martijn Gloerich (@GloerichLab) from @UMCUtrecht on Mechanical control of epithelial cell division. More to come!

Great 2 days at MedUni Vienna hosted by @Selma_OsMyers from Institute of Medical Chemistry and Pathobiochemistry. Giving a seminar on our concept of targeting mechanical homeostasis in cancer. Great meeting the Lilli Winter and Osmanagic-Myers Labs. Evening with our mentor Gerhard Wiche.

Excited to share our new @elife.bsky.social in collaboration with @Schiller lab.: Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis doi.org/10.7554/eLif...

#ECMatrix #chaperone #Clusterin #ECMresearch #Collagen #Integrin #AFM #Proteomics

"A microscopic cage: The image has 2 channels: black, phalloidin (actin) and color, alpha smooth muscle actin. The structure shows an architectural masterpiece of actin-bundle caging the nucleus in activated primary hepatic stellate cells isolated from mice."

"A microscopic cage: The image has 2 channels: black, phalloidin (actin) and color, alpha smooth muscle actin. The structure shows an architectural masterpiece of actin-bundle caging the nucleus in activated primary hepatic stellate cells isolated from mice."

Happy Monday... Happy to share the picture of our colleague Srikant Ojha winning EuBI Node Picture of the Month 2024/25 competition! (imcf.natur.cuni.cz/IMCF/picture...)

Huge thanks to all the co-authors including L. Frick, S.M. Meier-Menches, Mathias Heikenwälder, D. Jirak and their teams and involved funding agencies! @NUVR_cz @imgprague.bsky.social

💊 Plectin targeting: Our novel plectin inhibitor, plecstatin, effectively blocks HCC progression in vivo. Targeting plectin could open new doors for HCC therapy—much needed, as novel modes of action in the HCC pipeline are highly sought after!

🐭 In vivo HCC models: Knocking out or inhibiting plectin in preclinical liver cancer models significantly reduced tumor growth & metastasis—supporting its crucial role in disease progression.

🔬 In vitro experiments: We found that plectin enhances colony formation, invasion, and mechanosignaling, making tumor cells more aggressive. Disrupting plectin weakens cytoskeletal integrity and reduces the ability of cancer cells to spread.

📊 HCC patient meta-analysis: Our data show that plectin is upregulated in HCC tumors, advanced TNM stages and correlates with poor patient prognosis. This suggests plectin is not just a bystander but a key player in liver cancer progression.

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistan...

Excited to share our new @elife.bsky.social paper! We show that plectin fuels the growth & metastasis of hepatocellular carcinoma (HCC). Targeting plectin could be promising in HCC therapy, as we show using a novel plectin inhibitor, plecstatin! elifesciences.org/articles/102... #plectin #HCC

Hello! The Martin Gregor lab @imgprague is now on Bluesky! We will tweet about our #mechanobiology work, pretty microscopy images and videos and more. FOLLOW us!