Carlo Barnaba 🇮🇹🇲🇽

On LinkedIn, everybody is “thrilled”.

Oops...that happens when your inner rocker forgets you have an important and formal Zoom meeting...😶

PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses | mBio The antiviral response is largely regulated by post-translational modifications (PTM), including ADP-ribosylation. PARP14 is an ADP-ribosyltransferase that is upregulated by interferon and is under po...

@FehrLab has new research on the antiviral functions of PARP14 which shows PARP14 represses both coronavirus and herpes simplex virus 1 (HSV-1) replication.
Learn more at journals.asm.org/doi/10.1128/mbio.02299-25

Human microglia bright field image segmented with CellPose 4.

CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.

Painting of myself from a trainee

I love my trainees ❤️#littlejoyindarktimes

Post a PERFECT album from the 90s that isn't Nirvana or Pearl Jam.

Indeed. It's ruining an entire generation of trainees in science. They've just stopped thinking. And reading.

This is very good news

I’m fighting this AI nonsense every single day. Trainees who answer even simple emails using ChatGPT. Trainees looking for hypotheses using ChatGPT. Trainees who don’t read papers because ChatGPT summarizes literature (in a very shitty way).

How many lab members is too many lab members? #newPI

a cartoon character is laying in bed with a blue pillow on his head . Alt: a cartoon character is laying in bed with a blue pillow on his head .

As soon as my wife leaves town, my insomnia kicks in. Arsh 😡

There could be 10,000 reason why someone would like to visit a close relative.

My niece from Mexico 🇲🇽 was blocked at the airport and had to go back. She was going to visit us for a few days. No reason provided, she’s a scientist as well. We have stopped all travel abroad.

Our protocol for gene editing is online and all plasmids are on @addgene.bsky.social! CRISPR away everybody and get in touch if you need anything 🤩

Yes, I've seen this multiple times lately, both Chrome and Edge.

Slightly diminish a band: The Palliative

This is the stupidest time ever.

Dog

Ginger(bread Man) 🐕

You are walking through a crowd. One in ten people you meet believes the Earth is flat. 😑

I’m particularly referring to scientific hypothesis. I use often AI for trivial tasks.

I see more and more often trainees using AI to generate hypotheses. Brain is shrinking very fast nowadays.

Osprey. 🫠

Bookmark with Lincoln’s quote: To sin by silence when they should protest makes cowards of men

Found this inspirational quote as a bookmark in a used book. Very relevant.

Good catch.

With all due respect, why do you need to image at 12ms for 7 min, it is a mystery to me.

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency Republicans on spending committee push back against proposed reorganization and overhead cuts

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Got it. Very interesting indeed.

See, I can’t. “Dominant negative lethal” sounds so intimidating. Thanks 😊😄

Wise geneticists/CRISPRists out there. I am knocking out two genes (encoding for two isoforms) with a dual sgRNA Cas9 plasmid. I can get a dual knock-out (isoforms A and B) and a knock-out of isoform B, but no knock-out of isoform A alone. Any guess? Done this two times already, very reproducible.

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social