Alfredo Smiriglia

Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes - Cell Death & Disease Cell Death & Disease - Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes

📣 It’s been a productive few days for our group!
💡Our new paper in 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 shows that lead nitrate drives NRF2-dependent metabolic reprogramming and proliferation in hepatocytes.
With Università di Cagliari & Università di Torino, funded by MUR#PRIN2022.
🔗 www.nature.com/articles/s41...

🚨 Our new paper is now out in 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩!

ESR1 mutations in ER⁺ breast cancer rewire lipid metabolism, creating a ferroptosis vulnerability 🔬
ACSL4 is a key biomarker & combo with SERDs offers a new strategy.
👏 Congrats to the whole #TBTlab & collaborators!

aacrjournals.org/cancerres/ar...

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.

www.nature.com/articles/s41...

Congrats Sara and team :)

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds - Nature Communications Cholesterol lowering medication positively affects anti-cancer immune response, but the underpinning mechanism is not fully known. Here authors show that the effect is mediated by specific cholesterol...

I may have underestimated how interesting STING is…

www.nature.com/articles/s41...

CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer - Molecular and Cellular Biochemistry Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...

.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience

@alfredo95.bsky.social 🤟

Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease - Cell Death & Disease Cell Death & Disease - Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease

🚨 📣 Our latest study out in @springernature.com 𝘊𝘦𝘭𝘭 𝘋𝘦𝘢𝘵𝘩 & 𝘋𝘪𝘴𝘦𝘢𝘴𝘦, takes us beyond our usual cancer research comfort zone to explore how #estrogen influences the progression of #MASLD. Well done to @alfredo95.bsky.social and the rest of the team! 🙏

www.nature.com/articles/s41...