Microbial Biotechnology (MBT)

#MicroSky: ENVIRON BIOTECH: Vidal et al discuss that deep beneath Earth’s surface, life thrives in extremes. Subsurface microbiology reveals the limits and origins of life, and guides the search for biosignatures on Mars, icy moons, and distant exoplanets. Do not miss doi.org/10.1111/1751...

#MicroSky: ENVIRON BIOTECH: Selenium detox meets green nanotech. Stenotrophomonas converts toxic Se oxyanions into antimicrobial selenium nanoparticles with strain-specific killing mechanisms. Biogenic SeNPs are eco-friendly, broad-spectrum antimicrobials. doi.org/10.1111/1751...

#MicroSky: FERMENTATION: Acetic acid buildup can spoil fermentations—but real-time detection is hard. A whole-cell bacterial biosensor enables low-cost, sensitive, headspace AC monitoring supporting early intervention & better quality control. The future ahead by Kesler et al doi.org/10.1111/1751...

#MicroSky: BIOTECH-ENVIRONMENT: Rising CO₂ demands smarter biomanufacturing. A gas-linked co-culture pairing heterotrophs with autotrophs recycles emitted CO₂, nearly doubles PHB & carotenoid output, and cuts net CO₂ by >20%. Learn about novel circular carbon biorefineries. doi.org/10.1111/1751...

#MicroSky: ONE HEALTH: Type 2 diabetes is linked to the gut microbiota: Probiotics, prebiotics, synbiotics & fecal microbiota transplantation show promise in restoring microbial balance and improving metabolic health. Learn about new avenues for prevention and therapy. doi.org/10.1111/1751...

#MicroSky: Microbial Literacy: In a world of cascading, human-made crises & information overload, better decisions are urgent. Critical thinking, taught early & practiced widely, is our best defense against bias, misinformation, and self-harm to society and planet. doi.org/10.1111/1751...

#MicroSky: Plasmid vectors still underpin molecular biology, but convenience shouldn’t trump design. De Lorenzo & Martínez revisit copy number, selection & stability, and explores modular AI-assisted vector design for robust synthetic biology across the microbial world. doi.org/10.1111/1751...

#MicroSky: ONE HEALTH: Choudhury et al engineered Lactococcus lactis to deliver antimicrobial peptides that selectively target Fusobacterium nucleatum, a key driver of colorectal cancer, reducing biofilms & preserving gut microbiome diversity. doi.org/10.1111/1751...

#MicroSky: Microbial consortia outperform single strains, but testing combinations is a bottleneck. They show that the BSocial tool predicts “social consortia” and efficiently selects stable, high-performing plant growth–promoting communities. Advancing biofertilizer design! doi.org/10.1111/1751...

#MicroSky: BE SOCIAL: Science Fun Day outreach for primary pupils in Essex boosted enjoyment of science, interest in science careers, and understanding of why microbes matter, showing how hands-on engagement can inspire future scientists. Don’t miss Archer et al. doi.org/10.1111/1751...

#MicroSky: Olanzapine is linked to fatty liver disease. Wang et al found altered gut microbiota, i.e. Akkermansia muciniphila, n affected patients. Supplementing A. muciniphila reduced liver injury in rats via the gut/liver axis, suggesting a new microbiota-based therapy. doi.org/10.1111/1751...

#MicroSky: In times of climate disruption and social unrest, education must go beyond facts. Imagination, undervalued in “hard” sciences, is essential. Microbiology shows how imagining invisible worlds can foster responsibility, citizenship, and regenerative futures. doi.org/10.1111/1751...

#MicroSky: Pichia pastoris proves its power as a sustainable, high-yield platform for recombinant proteins: methanol levels allow tuning N/O-glycosylation. Optimizing induction boosts yield, controls glycan complexity, & streamlines large-scale bioprocessing. Read Ohara et al doi.org/10.1111/1751...

#MicroSky: ANTIBIOTIC RESISTANCE: Multi-halogenated indoles kill drug-resistant S. aureus, disrupt biofilms, induce ROS, wipe out persisters, block resistance, inhibit quorum sensing/haemolysis, and synergize with aminoglycosides. Read Sim et al in MBT. doi.org/10.1111/1751...

#MicroSky: Fermentation: Lentilactobacillus emerges as a strong malolactic starter, outperforming O. oeni at low temperatures and improving reliability, spoilage resistance, and starter diversity in cool-climate wines. Find more in Mantegazza et al. doi.org/10.1111/1751...

a great review!

Phylogeny‐Aware Metabologenomics Accurately Assigns Natural Products to Biosynthetic Gene Clusters We report a statistical approach for associating biosynthetic gene clusters with their cognate metabolites and demonstrate its unprecedented power for scalable natural product discovery. Notably, it ...

Phylogeny-­ Aware Metabologenomics Accurately Assigns
Natural Products to Biosynthetic Gene Clusters

@microbiotech.bsky.social by Judith Boldt et al from Ulrich Nübel and @drrolfmueller.bsky.social

enviromicro-journals.onlinelibrary.wiley.com/doi/pdf/10.1...

#MicroSky: BIOGAS: Metagenomes from anaerobic digesters uncovered a new bacterial order, Candidatus Darwinibacteriales, a key syntrophic acetate oxidizer partnering with methanogens. A major step toward illuminating an uncultured but abundant player in biogas production. doi.org/10.1111/1751...

#MicroSky: Using multi-omics on 63 actinomycetes, Abdelrahman et al pinpointed 75 metabolites linked to blocking Phytophthora infestans, showing how comparing closely related strains can reveal key anti–late-blight compounds. Read: doi.org/10.1111/1751...

#MicroSky: Hot in MBT 2025: A new genome-editing toolkit and improved chassis for Caldimonas thermodepolymerans accelerate its development as a thermophilic producer of biodegradable plastics. Read Grybcuk-Ieremenko et al in MBT. doi.org/10.1111/1751...

#MicroSky: Fungal EVs to fight nematodes? A nematode-trapping fungus is now an RNA delivery platform to shuttle RNAi molecules into root-knot nematodes, slashing their mobility and infectivity. An eco-friendly leap toward sustainable pest control. Read Huang et al. doi.org/10.1111/1751...

#MicroSky: HOT IN MBT 2025 West Nile virus spread rapidly after its 1999 U.S. introduction, driven by Culex mosquitoes and viral mutations. With cases rising in Europe & warming climates expanding vector ranges, temperature-driven transmission has become a key research focus. doi.org/10.1111/1751...

#MicroSky: Hot in MBT 2025: Key gaps limit microbiome–gut–brain therapies, from unclear probiotic mechanisms to poor translation from animals to humans. Slykerman review maps successes, failures & how mechanistic & in silico insights can guide smarter psychobiotic advances. doi.org/10.1111/1751...

#MicroSky: Recognized contributions in Microbial Biotechnology. Streptomyces secondary metabolites. Streptomyces species yield novel compounds for agri-food and medicine. Explore Gómez-Escribano & Bibb: Microbial biotechnology. doi.org/10.1111/j.17...

#MicroSky: Hot in MBT 2025: Engineered bacteria are becoming living microrobots for diagnosing and treating disease. Alone or in consortia, they improve precision and therapeutic impact. Challenges in safety, stability and host interactions remain. Find more in Jin et al. doi.org/10.1111/1751...

#MicroSky: Glyco-engineered VLPs show big promise for One Health: Glycosylation of virus–like particles boosts stability, improves immune uptake & strengthens cellular responses. A smart step toward more effective vaccines for livestock. Read Li et al. doi.org/10.1111/1751...

#MicroSky: HOT in MBT 2025 AI is transforming antimicrobial-peptide discovery—deep learning, large protein language models, graph neural networks and structure-guided design now drive major advances. The challenges and future opportunities are discussed by Brizuela et al. doi.org/10.1111/1751...

I love it! DNA strands make the perfect garland. 🧬

#MicroSky: The MBT team wishes everyone a restful holiday season with their loved ones and all the best for the end of the year. 🦠 🎄

#MicroSky: Special Issue on “The Contribution of Microbial Biotechnology to Sustainable Development Goal 3: Ensure healthy lives and promote well-being for all at all ages". Submit your manuscript online at: mc.manuscriptcentral.com/microbio. Deadline 📆 20 December 2025. Thanks for RT