Séb Wielgoss

Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019 - PubMed Gram-positive pathogens were the dominant historical pathogens of bacteraemia. The trends seen here-with many near-universally active antibiotics-indicate little hazard of this situation returning. Nevertheless, few treatments exist in some settings, notably multi-resistant E. faecium endocarditis.

Interesting paper

'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019'

TL;DR:
- dramatic falls in MRSA
- pneumococcal resistance rates low
- E. faecium more prevalent (and more vanR) than E. faecalis

pubmed.ncbi.nlm.nih.gov/41140273/

Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio

Interesting paper on bacteriophage genomics and bioinformatics

'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues

academic.oup.com/bib/article/...

Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!

Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.

duunitori.fi/tyopaikat/ty...

Cool PNAS paper by @jordivangestel.bsky.social and colleagues
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]

Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation

www.pnas.org/doi/10.1073/...

A call for caution in the biological interpretation of viral auxiliary metabolic genes - Nature Microbiology This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.

New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...

Longstanding collaboration with Scott Manalis where we have developed technology to measure single cell growth rates of bacteria in native seawater with some very surprising results.
www.biorxiv.org/content/10.1...

Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism | Applied and Environmental Microbiology Acinetobacter baylyi ADP1 is a bacterial chassis of interest to microbiologists in academia and industry due to its extreme natural competence and wide metabolic range. Its ability to take up DNA from...

Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism

#ApplEnvironMicrobiol from Jeff Barrick

journals.asm.org/doi/10.1128/...

very cool work and a milestone in synthetic biology. how impressive are the new phage genomes?

with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look

Exclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genes Abstract. Plasmid conjugation is a major driver of antibiotic resistance dissemination in bacteria. In addition to genes required for transfer and maintena

Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes.

@nfrk92.bsky.social
@narjournal.bsky.social

academic.oup.com/nar/article/...

GAG512: Eine kleine Geschichte der Sonnenbrille - Geschichten aus der Geschichte Eine Geschichte über Sonnenschutz, Identität und Rebellion

Mittwoch! Passend zur Sommerszeit: eine kleine Geschichte der Sonnenbrille. Wir sprechen nicht nur über ihre Anfänge, sondern vor allem über die Bedeutung, die sie im Laufe ihrer Geschichte erhalten hat.

https://www.geschichte.fm/archiv/gag512/

@eseb Distinguished Fellow Talk Dieter Ebert 🇨🇭, has been an ESEB member since his PhD and played a key role in the society all of his career. #ESEB2025

A scientific figure from the linked paper by Betancourt et al. It shows on the left, that most (70%) evolutionary biologists who switched to a career outside of academia felt prepared. The right panel is a graph showing what training individuals would like to have received more of during their academic career, with the top points being related to management skills.

"Overall, the message from this survey is positive– #evolutionary #biologists are readily employable outside of #academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic #careers"

https://www.biorxiv.org/content/10.1101/2025.08.19.671061v1

Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio

Need advice on which of the many virus 🦠 prediction tools to apply for your phage research🔎?

This guide equips you for your bioinformatic analyses in your
"quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth."

⬇️

doi.org/10.1093/bib/...

STEPS To It Announcing a new program, called STEPS, to simulate the dynamics of evolving microbial populations.

Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime.

telliamedrevisited.wordpress.com/2025/08/12/s...

STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.

Interested in exploring prophages in your (meta)genomes, but don't know how and where to start? We've put together a beginners guide to exploring viral diversity in prokaryotes @marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social

Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio

Our new review is out in
Briefings in Bioinformatics

Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world

@ccwendling.bsky.social
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social

doi.org/10.1093/bib/...