American Journal of Kidney Diseases

Possible conceptions of optimal care in pediatric nephrology

Perspective by Taylor R. House, Ryan J. Coller, and Aaron Wightman:

Optimal Care to Promote Flourishing: Articulating the Purpose of Pediatric Nephrology

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Time to Treatment Discontinuation among Apixaban Users and Time to Initiation of Oral Anticoagulation Among Matched Non-Users. Note: OAC – oral anticoagulant. Apixaban users (in red) had filled their first apixaban prescription within 30 days from their new diagnosis with atrial fibrillation. Continued use was present when a subsequent apixaban prescription was filled within no more than 7 days after the most recent supply was exhausted. If no refill occurred, 7 days were added to the most recent days’ supply. Apixaban use also ended when a prescription for a different OAC was filled. Non-users (in blue) of an oral anticoagulant within the same number of days from their new diagnosis with atrial fibrillation as their matched apixaban user were followed for any subsequent initiation of any oral anticoagulant.

Effectiveness and Safety of Apixaban Initiation Following Newly-Diagnosed Atrial Fibrillation in Patients With Kidney Failure on Hemodialysis

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Immunohistochemical findings in patients with autosomal dominant tubulointerstitial kidney disease (ADTKD).

Review by Anthony Bleyer et al:

Autosomal Dominant Tubulointerstitial Kidney Disease: A Review

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Selecting Antihypertensive Medications for Kidney Transplant Recipients: Flying Blind

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Renal Cell Carcinoma Subtypes Based on Histology. (A) Clear cell renal cell carcinoma. (B) Papillary renal cell carcinoma. (C) Chromophobe renal cell carcinoma. (D) Oncocytoma. (E) Medullary renal cell carcinoma. Based on information in Williamson SR. Renal cell carcinoma classification: what matters? Diagn Histopathol. 2022;28(6):301-308. doi:10.1016/j.mpdhp.2022.03.004; and Garje R, Elhag D, Yasin HA, Acharya L, Vaena D, Dahmoush L. Comprehensive review of chromophobe renal cell carcinoma. Crit Rev Oncol Hematol. 2021:160:103287. doi:10.1016/j.critrevonc.2021.103287

Core Curriculum by Kristen Tillquist, Sandipan Shringi, Anthony Chang, and Susie L. Hu:

The Nephrologist’s Perspective in Evaluation and Management of Localized Renal Masses: Core Curriculum 2025 #OpenAccess

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EDITORIAL: Telemedicine in Dialysis: Established Gains Yet Enduring Gaps to Enhance the Quality of Care

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Membranoproliferative glomerulonephritis with diffuse lobular simplification of the glomeruli, caused by extensive endocapillary hypercellularity (Jones silver stain).

#RenalPath: Membranoproliferative glomerulonephritis (MPGN) is a lesion caused by subendothelial immune complex deposits.

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2025 AJKD Editors' Choice Award winning article: Prevalence of Severe Mental Illness and Its Associations With Health Outcomes in Patients With CKD: A Swedish Nationwide Study

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#CKD #VisualAbstract

Nephrologist Perspectives on Using Telemedicine During In-Center Hemodialysis: A Qualitative Study

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#VisualAbstract

(A) Diffuse medium and small renal arterial stenoses (yellow arrows) and microaneurysms (red arrows). (B) Intact large abdominal vessel angiogram and a small splenic artery aneurysm (red arrow in inset). (C). Distended arteriole occluded by a thrombus (arrowhead), consistent with thrombotic microangiopathy (PAS stain, ×200).

#Quiz from October 2025:

A 16-year-old male patient presented to an ED with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath.

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Suggested weight loss treatment pathways to achieve eligibility for kidney transplantation for patients with advanced kidney disease. aGLP1/GIP RA should be considered in all kidney transplant candidates as either a bridge to MBS, an alternative to MBS, or to enhance the weight loss effect of MBS. bNo rigid upper age limit for bariatric surgery. Frailty, not chronological age, should guide decision making. Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; GIP, glucose-dependent insulinotropic polypeptide; GLP1 RA, glucagon-like peptide-1 receptor agonist; MBS, metabolic bariatric surgery; T1D, type 1 diabetes; T2D, type 2 diabetes; SPK, simultaneous pancreas and kidney transplant.

Mini-Review by Aleksandra Kukla, Ricardo Cohen, and Allon Friedman:

Metabolic Bariatric Surgery in Kidney Transplant Candidates

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Schematic illustration of neurovascular nephron connectivity, mother glomeruli (A), and their proposed roles in renal physiology and pathology (B). A: Neuronal (green) and vascular (red) mechanisms of internephron coupling are represented. Note the high density of neuronal network connecting the mother glomerulus to vertical (from the same vascular tree) and horizontal (from neighboring vascular tree) glomerular communities. B: Schematic of the juxtaglomerular apparatus (JGA) depicting the sympathetic nerves (magenta) that innervate all individual MD cells in contrast to sensory nerves (cyan) that are present only in the flanking regions of MD plaque. Abbreviations: AA, afferent arteriole; EA, efferent arteriole

IN THE LITERATURE: Are Mother Glomeruli in Good or Bad Company?

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Proportion of participants with influenza and COVID-19 vaccine hesitancy. The sample excluded four participants who responded to the influenza vaccine questionnaire but did not to the COVID-19 vaccine questionnaire, all of them had neither influenza nor COVID-19 vaccine hesitancy.

OPEN ACCESS: Perceptions About Influenza and COVID-19 Vaccines Among People With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

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Editorial by Nivetha Subramanian and Shuchi Anand:

Vaccines as a Core Conversation in Nephrology

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EDITORIAL: Breaking Down Barriers to Reproductive Health Care in CKD

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In A Few Words essay by Christina Fang, MD: Physician as Patient

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In A Few Words essay by Yuki Teramoto, MD, PhD: The Paper Balloon

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Flow chart for overall study population and more in-depth analysis

A Drug-Wide Association Study on Medications Associated With Cystatin C Estimated GFR

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IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency

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Contraceptive Use and Reproductive Health in Women With CKD: A Qualitative Study Of Nephrologists in the United States

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#VisualAbstract

Time line for the development of different eGFR equations(adapted from Gansevoort et al, 2023). ∗Refers to eGFRcr formulae excepting where cystatin is shown. eGFRcr overestimates and underestimates are median values versus mGFR. Abbreviations: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration equation; CKD-EPI 2009 NB, CKD-EPI 2009 equation without race coefficient; eGFR, estimated glomerular filtration rate; eGFRcr, estimated glomerular filtration rate creatinine-based formulae; EKFC, European Kidney Function Consortium; MDRD-4, 4-variable Modification of Diet in Renal Disease equation; mGFR, measured glomerular filtration rate.

Pharmaceutical Practice Considerations Regarding Adoption of the Race-Free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 Equations

bit.ly/4rtzHTK (OPEN ACCESS)

The December 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

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A 52-year-old man with kidney failure due to type 1 diabetes mellitus who is receiving hemodialysis presents with generalized xerosis of the bilateral shins and ankles with areas of ichthyosiform change and scattered lightly hyperpigmented macules and patches.

Skin Disorders in Kidney Disease: Core Curriculum 2026

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Typical patterns of drug-induced neutropenia.

Hematologic Considerations in Kidney Transplantation: Core Curriculum 2025

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EDITORIAL: Gaining a Genomic Foothold on Unexplained Kidney Failure

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#RenalPath: Diffuse granular capillary wall staining for phospholipase A2 receptor (PLA2R). PLA2R staining is positive in approximately 70% of patients with clinically idiopathic membranous nephropathy (immunofluorescence microscopy, PLA2R).

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Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study

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#VisualAbstract #CKD

Association of Influenza Vaccination With Acute Kidney Injury: A Prospective Target Trial Emulation Study

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Breakdown of solved cases by gene category. Breakdown of the solved uKF cases by gene and phenotypic category. All percentages represent a proportion of the total solved cases (n=38). ADTKD, autosomal dominant tubulointerstitial kidney disease; CAKUT, congenital anomalies of the kidneys and urinary tract.

Quantifying APOL1, Human Leukocyte Antigen, and Other Genetic Contributions to Unexplained Kidney Failure #OpenAccess

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The December 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/3XUKQPQ